A Novel Therapeutic Combination Using PD 0332991 and Bortezomib: Study in the 5T33MM Myeloma Model

CDK inhibitors: positive and negative regulators of G1-phase progression

1999 • 6,003 citations

Enhanced Growth of Mice Lacking the Cyclin-Dependent Kinase Inhibitor Function of p27

1996 • 1,283 citations

Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts

2004 • 1,165 citations

BCL-6 Represses Genes that Function in Lymphocyte Differentiation, Inflammation, and Cell Cycle Control

2000 • 862 citations

Blimp-1 Is Required for the Formation of Immunoglobulin Secreting Plasma Cells and Pre-Plasma Memory B Cells

2003 • 797 citations

Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.

1994 • 731 citations

Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination

2006 • 725 citations

Novel INK4 Proteins, p19 and p18, Are Specific Inhibitors of the Cyclin D-Dependent Kinases CDK4 and CDK6

1995 • 657 citations

Loss of Pax5 Promotes Plasma Cell Differentiation

2006 • 216 citations

A Novel Orally Active Small Molecule Potently Induces G1 Arrest in Primary Myeloma Cells and Prevents Tumor Growth by Specific Inhibition of Cyclin-Dependent Kinase 4/6

2006 • 213 citations

Induction of Cell Cycle Arrest and B Cell Terminal Differentiation by CDK Inhibitor p18 and IL-6

1997 • 159 citations

Organ involvement and phenotypic adhesion profile of 5T2 and 5T33 myeloma cells in the C57BL/KaLwRij mouse

1997 • 155 citations

Mantle cell lymphoma cells express predominantly cyclin D1a isoform and are highly sensitive to selective inhibition of CDK4 kinase activity

2006 • 146 citations

Pharmacologic inhibition of CDK4/6: mechanistic evidence for selective activity or acquired resistance in acute myeloid leukemia

2007 • 126 citations

Multiple myeloma biology: lessons from the 5TMM models

2003 • 124 citations

Mutually Exclusive Cyclin-Dependent Kinase 4/Cyclin D1 and Cyclin-Dependent Kinase 6/Cyclin D2 Pairing Inactivates Retinoblastoma Protein and Promotes Cell Cycle Dysregulation in Multiple Myeloma

2005 • 112 citations

CDK Inhibitor p18INK4c Is Required for the Generation of Functional Plasma Cells

2002 • 106 citations

Homeostatic cell-cycle control by BLyS: Induction of cell-cycle entry but not G₁/S transition in opposition to p18^INK4cand p27^Kip1

2004 • 58 citations

Plasma cells and multiple myeloma

2003 • 8 citations

Targeting Cdk4/6 in Combination Therapy Overcomes Proteasome Inhibitor Resistance in Multiple Myeloma through Synergistic Mitochondria Depolarization.

2007 • 2 citations