Cytotoxic Effects on Hair Cells of Guinea Pig Cochlea Produced by Pneumolysin, the Thiol Activated Toxin ofStreptococcus pneumoniae

Bacterial toxins and cell membranes

1978 • 471 citations

Reduced virulence of a defined pneumolysin-negative mutant of Streptococcus pneumoniae

1989 • 335 citations

Pathology of Sensorineural Hearing Loss in Otitis Media

1972 • 225 citations

Activation of human complement by the pneumococcal toxin pneumolysin

1984 • 220 citations

Effect of immunization with pneumolysin on survival time of mice challenged with Streptococcus pneumoniae

1983 • 205 citations

Purification and immunogenicity of genetically obtained pneumolysin toxoids and their conjugation to Streptococcus pneumoniae type 19F polysaccharide

1991 • 154 citations

Damage to Cell Membranes by Pore-Forming Bacterial Cytolysins

2015 • 151 citations

Effect of Streptococcus pneumoniae on human respiratory epithelium in vitro

1989 • 119 citations

Mechanisms in Bacterial Toxinology

1977 • 117 citations

Pneumolysin Induces the Salient Histologic Features of Pneumococcal Infection in the Rat Lung In Vivo

1991 • 113 citations

The Role of Corticosteroid Therapy in Children With Pneumococcal Meningitis

1991 • 103 citations

Inhibition of in vitro human lymphocyte response by the pneumococcal toxin pneumolysin

1984 • 86 citations

Sensorineural Hearing Loss in Experimental Purulent Otitis Media due to Streptococcus pneumoniae

1985 • 76 citations

Cellular location of pneumolysin

1977 • 62 citations

Endotoxin induced damage to the cochlea in guinea pigs.

1991 • 44 citations

Outer Hair Cells as Potential Targets of Inflammatory Mediators

1990 • 42 citations

High resolution scanning electron microscopy of stereocilia in the cochlea of normal, postmortem, and drug‐treated guinea pigs

1990 • 23 citations

The effect of bacterial endotoxin upon the morphology of the tectorial membrane and stereocilia in the guinea pig cochlea.

1991 • 5 citations