Pneumolysin Induces the Salient Histologic Features of Pneumococcal Infection in the Rat Lung In Vivo

Pneumococcal Bacteremia with Especial Reference to Bacteremic Pneumococcal Pneumonia

1964 • 947 citations

Correlation between Serum IgG-2 Concentrations and the Antibody Response to Bacterial Polysaccharide Antigens

1980 • 472 citations

The Induction of Meningeal Inflammation by Components of the Pneumococcal Cell Wall

1985 • 358 citations

Reduced virulence of a defined pneumolysin-negative mutant of Streptococcus pneumoniae

1989 • 335 citations

Failure of Intensive Care Unit Support to Influence Mortality From Pneumococcal Bacteremia

1983 • 263 citations

Contribution of autolysin to virulence of Streptococcus pneumoniae

1989 • 261 citations

Molecular cloning, characterization, and complete nucleotide sequence of the gene for pneumolysin, the sulfhydryl-activated toxin of Streptococcus pneumoniae

1987 • 243 citations

Activation of human complement by the pneumococcal toxin pneumolysin

1984 • 220 citations

Crofton and Douglas's Respiratory Diseases

2000 • 215 citations

Effect of immunization with pneumolysin on survival time of mice challenged with Streptococcus pneumoniae

1983 • 205 citations

Inhibition of human polymorphonuclear leukocyte respiratory burst, bactericidal activity, and migration by pneumolysin

1983 • 181 citations

Pneumolysin, the thiol-activated toxin of Streptococcus pneumoniae, does not require a thiol group for in vitro activity

1989 • 122 citations

Effect of Streptococcus pneumoniae on human respiratory epithelium in vitro

1989 • 119 citations

Induction of Pulmonary Inflammation by Components of the Pneumococcal Cell Surface^1–2

1987 • 118 citations

Comparative efficacy of pneumococcal neuraminidase and pneumolysin as immunogens protective against Streptococcus pneumoniae

1988 • 110 citations

Measurement of antibody responses to pneumolysin-A promising method for the presumptive aetiological diagnosis of pneumococcal pneumonia

1989 • 108 citations

STUDIES ON THE MECHANISM OF RECOVERY IN PNEUMOCOCCAL PNEUMONIA

1941 • 93 citations

Inhibition of in vitro human lymphocyte response by the pneumococcal toxin pneumolysin

1984 • 86 citations

Expression of the pneumolysin gene in Escherichia coli: rapid purification and biological properties

1989 • 72 citations

Effects of pneumolysin on human polymorphonuclear leukocytes and platelets

1981 • 68 citations

Pneumococcal Pneumonia; Diagnostic, Epidemiologic, Therapeutic and Prophylactic Considerations

1986 • 62 citations

Cellular location of pneumolysin

1977 • 62 citations

The role of complement in inflammation during experimental pneumococcal meningitis

1986 • 60 citations

A Reassessment of Pneumococcal Vaccine

1984 • 59 citations

Immunopathology of Experimental Bronchiectasis

1989 • 58 citations

Inhibition of human monocyte respiratory burst, degranulation, phospholipid methylation and bactericidal activity by pneumolysin.

1986 • 51 citations

Effect of thiol-activated toxins (streptolysin O, alveolysin, and theta toxin) on the generation of leukotrienes and leukotriene-inducing and -metabolizing enzymes from human polymorphonuclear granulocytes

1985 • 42 citations

Immune response of neonates to pneumococcal polysaccharide-protein conjugate.

1982 • 31 citations

Mucin as an Aid in the Experimental Production of Lobar Pneumonia

1936 • 29 citations

Pneumococcal cellulitis: A rare manifestation of pneumococcaemia in adults

1989 • 25 citations

Partner Drugs: A New Outlook for Bacterial Meningitis

1988 • 21 citations

Ocular Toxin of the Pneumococcus

1971 • 19 citations

Animal models of pneumonia for evaluation of antimicrobial therapy

1985 • 15 citations

Alveolar epithelial responses in experimental streptococcal pneumonia

1989 • 7 citations

Pneumococcal vaccination

1989 • 3 citations