Structure, transmembrane topology and helix packing of P‐type ion pumps

Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy

1990 • 2,969 citations

Amino-acid sequence of a Ca2+ + Mg2+ -dependent ATPase from rabbit muscle sarcoplasmic reticulum, deduced from its complementary DNA sequence

1985 • 1,126 citations

The probable arrangement of the helices in G protein-coupled receptors.

1993 • 977 citations

Location of high affinity Ca2 +-binding sites within the predicted transmembrahe domain of the sarco-plasmic reticulum Ca2+-ATPase

1989 • 569 citations

Structure-function relationships in the sodium-potassium ATPase .alpha. subunit: site-directed mutagenesis of glutamine-111 to arginine and asparagine-122 to aspartic acid generates a ouabain-resistant enzyme

1988 • 403 citations

Three-dimensional cryo-electron microscopy of the calcium ion pump in the sarcoplasmic reticulum membrane

1993 • 231 citations

Two-dimensional arrays of proteins in sarcoplasmic reticulum and purified Ca2+-ATPase vesicles treated with vanadate.

1983 • 177 citations

Extensive digestion of Na+,K(+)-ATPase by specific and nonspecific proteases with preservation of cation occlusion sites.

1992 • 157 citations

Three-dimensional reconstruction of negatively stained crystals of the Ca2+-ATPase from muscle sarcoplasmic reticulum

1986 • 153 citations

Membrane topology and omeprazole labeling of the gastric hydrogen ion-potassium-adenosinetriphosphatase

1993 • 135 citations

A method for α‐helical integral membrane protein fold prediction

1994 • 112 citations

The site of action of pantoprazole in the gastric H+/K+-ATPase

1993 • 106 citations

Formation of two-dimensional crystals in pure membrane-bound Na⁺ ,K⁺ -ATPase

1981 • 105 citations

Identification of an extracytoplasmic region of H+,K(+)-ATPase labeled by a K(+)-competitive photoaffinity inhibitor.

1991 • 100 citations

Kinetic analysis of ouabain binding to native and mutated forms of Na,K-ATPase and identification of a new region involved in cardiac glycoside interactions.

1993 • 94 citations

The separate profile structures of the functional calcium pump protein and the phospholipid bilayer within isolated sarcoplasmic reticulum membranes determined by X-ray and neutron diffraction

1985 • 89 citations

Dimer ribbons in the three-dimensional structure of sarcoplasmic reticulum

1985 • 82 citations

Structure of CaATPase: Electron microscopy of frozen-hydrated crystals at 6 Å resolution in projection

1990 • 78 citations

Membrane topology of a P-type ATPase. The MgtB magnesium transport protein of Salmonella typhimurium.

1993 • 73 citations

The epitope for monoclonal antibody A20 (amino acids 870-890) is located on the luminal surface of the Ca2(+)-ATPase of sarcoplasmic reticulum.

1990 • 71 citations

Location of Asn831 of the alpha chain of Na/K-ATPase at the cytoplasmic surface. Implication for topological models.

1993 • 71 citations

Topology of Na⁺,K⁺‐ATPase Identification of the extra‐ and intracellular hydrophilic loops of the catalytic subunit by specific antibodies

1988 • 66 citations

The Amino and Carboxyl Termini of the Neurospora Plasma Membrane H+-ATPase Are Cytoplasmically Located

1989 • 63 citations

Transmembranous organization of (Ca2(+)-Mg2+)-ATPase from sarcoplasmic reticulum. Evidence for lumenal location of residues 877-888.

1990 • 62 citations

Transmembrane organization of the sodium-potassium-ATPase determined by epitope addition

1993 • 62 citations

Crystallization of Ca2+-ATPase in detergent-solubilized sarcoplasmic reticulum.

1987 • 61 citations

Use of expression mutants and monoclonal antibodies to map the erythrocyte Ca2+ pump.

1992 • 58 citations

Epitope mapping by amino‐acid‐sequence‐specific antibodies reveals that both ends of the α subunit of Na⁺/K⁺‐ATPase are located on the cytoplasmic side of the membrane

1991 • 55 citations

cDNA cloning and membrane topology of the rabbit gastric H+/K+-ATPase α-subunit

1992 • 55 citations

Direct evidence for the cytoplasmic location of the NH2- and COOH-terminal ends of the Neurospora crassa plasma membrane H+-ATPase.

1990 • 51 citations

The three-dimensional structure of the Na,K-ATPase from electron microscopy.

1987 • 50 citations

Electron microscope observations on Ca2+-ATPase microcrystals in detergent-solubilized sarcoplasmic reticulum.

1988 • 50 citations

Three‐dimensional structure of renal Na,K‐ATPase determined by electron microscopy of membrane crystals

1985 • 47 citations

Evidence for the cytoplasmic location of the N- and C-terminal segments of sarcoplasmic reticulum (Ca2+Mg2+)-ATPase

1989 • 46 citations

Image Analysis of the Ca²⁺‐ATPase from Sarcoplasmic Reticulum^a

1986 • 41 citations

Functional consequences of alterations to hydrophobic amino acids located in the M4 transmembrane sector of the Ca(2+)-ATPase of sarcoplasmic reticulum.

1993 • 40 citations

Conformation of Ca(2+)-ATPase in two crystal forms. Effects of Ca2+, thapsigargin, adenosine 5'-(beta, gamma-methylene)triphosphate), and chromium(III)-ATP on crystallization

1994 • 39 citations

Three‐dimensional structure of (Na⁺ + K⁺)‐ATPase revealed by electron microscopy of two‐dimensional crystals

1985 • 38 citations

Immunoelectron microscopy of epitopes on Na,K-ATPase catalytic subunit. Implications for the transmembrane organization of the C-terminal domain.

1994 • 36 citations

Definition of surface-exposed and trans-membranous regions of the (Ca2+-Mg2+)-ATPase of sarcoplasmic reticulum using anti-peptide antibodies

1992 • 35 citations

Antibody epitope mapping of the gastric H+/K+-ATPase

1993 • 27 citations

Topology of Na,K‐ATPase α subunit epitopes analyzed with oligopeptide‐specific antibodies and double‐labeling immunoelectron microscopy

1993 • 27 citations

Determination of the sidedness of the C-terminal region of the gastric H,K-ATPase α subunit

1992 • 24 citations

Antigenic determinant of a monoclonal antibody: extracellular domain at the M3–M4 junction of the α-subunit of Na,K-ATPase

1990 • 21 citations

Three-dimensional structure of Na,K-ATPase determined from membrane crystals induced by cobalt-tetrammine-ATP

1992 • 20 citations

Three-dimensional structure of renal Na,K-ATPase determined from two-dimensional membrane crystals of the p1 form

1988 • 18 citations

Topology and Sites in the H,K‐ATPase

1992 • 18 citations

A monoclonal antibody recognizes an epitope in the first extracellular loop of the plasma membrane Ca2+ pump.

1992 • 18 citations

The carboxy terminus of sodium and potassium ion transporting ATPase is located on the cytoplasmic surface of the membrane

1993 • 16 citations

The Sodium Pump

1994 • 14 citations

A pH induced two‐dimensional crystal of membrane‐bound Na⁺,K⁺‐ATPase of dog kidney

1993 • 13 citations

Architecture of the Sodium Pump Molecule

1992 • 6 citations