Protonation and deprotonation of the M, N, and O intermediates during the bacteriorhodopsin photocycle

[69] Isolation of the cell membrane of Halobacterium halobium and its fractionation into red and purple membrane

1974 • 1,690 citations

Bacteriorhodopsin: a light-driven proton pump in Halobacterium Halobium

1975 • 994 citations

Bacteriorhodopsin and the purple membrane of halobacteria

1979 • 909 citations

Bacteriorhodopsin and Related Pigments of Halobacteria

1982 • 767 citations

Vibrational spectroscopy of bacteriorhodopsin mutants: light-driven proton transport involves protonation changes of aspartic acid residues 85, 96, and 212

1988 • 497 citations

Role of aspartate-96 in proton translocation by bacteriorhodopsin.

1989 • 348 citations

Aspartic acid-96 is the internal proton donor in the reprotonation of the Schiff base of bacteriorhodopsin.

1989 • 318 citations

Light-driven protonation changes of internal aspartic acids of bacteriorhodopsin: an investigation of static and time-resolved infrared difference spectroscopy using [4-13C]aspartic acid labeled purple membrane

1985 • 294 citations

Aspartic acids 96 and 85 play a central role in the function of bacteriorhodopsin as a proton pump.

1989 • 259 citations

Chromophore structure in bacteriorhodopsin's N intermediate: implications for the proton-pumping mechanism

1988 • 242 citations

Kinetics and stoichiometry of light-induced proton release and uptake from purple membrane fragments, Halobacterium halobium cell envelopes, and phospholipid vesicles containing oriented purple membrane

1976 • 222 citations

Replacement of aspartic acid-96 by asparagine in bacteriorhodopsin slows both the decay of the M intermediate and the associated proton movement.

1989 • 203 citations

A defective proton pump, point-mutated bacteriorhodopsin Asp96----Asn is fully reactivated by azide.

1989 • 185 citations

Flash photometric experiments on the photochemical cycle of bacteriorhodopsin

1975 • 165 citations

Bacteriorhodopsin photoreaction: identification of a long-lived intermediate N (P, R350) at high pH and its M-like photoproduct

1988 • 154 citations

Factors affecting the C:N stretching in protonated retinal Schiff base: a model study for bacteriorhodopsin and visual pigments

1987 • 145 citations

Pathways of the rise and decay of the M photointermediate(s) of bacteriorhodopsin

1990 • 139 citations

On the protein (tyrosine)-chromophore (protonated Schiff base) coupling in bacteriorhodopsin.

1984 • 138 citations

The quantum efficiency of proton pumping by the purple membrane of Halobacterium halobium

1980 • 130 citations

Correlation of photochemical cycle, H⁺ release and uptake, and electric events in bacteriorhodopsin

1984 • 125 citations

The Effect of Protonation and Electrical Interactions on the Stereochemistry of Retinal Schiff Bases

1985 • 122 citations

Flash-induced volume changes of bacteriorhodopsin-containing membrane fragments and their relationship to proton movements and absorbance transients.

1978 • 113 citations

Kinetic interaction between aromatic residues and the retinal chromophore of bacteriorhodopsin during the photocycle

1979 • 103 citations

Illumination-dependent changes in the intrinsic fluorescence of bacteriorhodopsin

1978 • 101 citations

Time‐course and stoichiometry of light‐induced proton release and uptake during the photocycle of bacteriorhodopsin

1986 • 100 citations

FTIR difference studies on apoproteins. Protonation states of aspartic and glutamic acid residues during the photocycle of bacteriorhodopsin

1987 • 84 citations

A correlation between proton pumping and the bacteriorhodopsin photocycle.

1984 • 59 citations

Functional reconstitution of halorhodopsin. Properties of halorhodopsin-containing proteoliposomes.

1988 • 54 citations

Ratio of the proton- and photochemical cycles in bacteriorhodopsin

1981 • 49 citations

The direction of light‐induced pH changes in purple membrane suspensions Influence of pH and temperature

1977 • 43 citations

Protein electric response signals from dielectrically polarized systems

1989 • 42 citations

Changes in the protonation state of bacterio-opsin during reconstitution of bacteriorhodopsin

1980 • 39 citations

Absolute quantum yields and proof of proton and nonproton transient release and uptake in photoexcited bacteriorhodopsin.

1983 • 39 citations

Interconversions of the M, N, and O intermediates in the bacteriorhodopsin photocycle

1990 • 38 citations

Turnover rate of the proton pumping cycle of bacteriorhodopsin: pH and light-intensity dependences

1989 • 35 citations

LIGHT‐INDUCED PROTON DISSOCIATION AND ASSOCIATION IN BACTERIORHODOPSIN

1981 • 32 citations

The effect of pH on proton transport by bacteriorhodopsin

1985 • 23 citations

[17] Rapid kinetic optical absorption spectroscopy of bacteriorhodopsin photocycles

1982 • 15 citations

Phase-Lifetime Spectroscopy of Photocycle Processes

1988 • 8 citations

Effect of pH on the stoichiometry of light-induced proton release and uptake from purple membrane suspensions

1985 • 6 citations