Cultured normal human hepatocytes do not synthesize lipoprotein-associated coagulation inhibitor: evidence that endothelium is the principal site of its synthesis.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

Culture of Human Endothelial Cells Derived from Umbilical Veins. IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGIC CRITERIA

1973 • 6,904 citations

Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.

1968 • 5,084 citations

Cytochemical Identification of Monocytes and Granulocytes

1971 • 2,735 citations

Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line

1979 • 1,305 citations

Tissue factor and hemostasis [published erratum appears in Blood 1988 Apr;71(4):1178]

1988 • 941 citations

Preparation of Suspensions of Washed Platelets from Humans

1972 • 857 citations

The lipoprotein-associated coagulation inhibitor that inhibits the factor VII-tissue factor complex also inhibits factor Xa: insight into its possible mechanism of action

1988 • 482 citations

Functional significance of the Kunitz-type inhibitory domains of lipoprotein-associated coagulation inhibitor

1989 • 475 citations

Cloning and characterization of a cDNA coding for the lipoprotein-associated coagulation inhibitor shows that it consists of three tandem Kunitz-type inhibitory domains.

1988 • 331 citations

Establishment of a novel human megakaryoblastic leukemia cell line, MEG- 01, with positive Philadelphia chromosome

1985 • 323 citations

Regulation of endothelial cell coagulant properties

1989 • 255 citations

Platelets secrete a coagulation inhibitor functionally and antigenically similar to the lipoprotein associated coagulation inhibitor

1988 • 212 citations

Purification and characterization of the lipoprotein-associated coagulation inhibitor from human plasma

1989 • 204 citations

Induction of amino acid transport in primary cultures of adult rat liver parenchymal cells by insulin.

1976 • 198 citations

Isolation and culture of adult hepatocytes from liver biopsies

1981 • 179 citations

Maintenance of cytochrome P-450 and metabolism of aflatoxin B1 in primary hepatocyte cultures

1977 • 178 citations

Optimization of Cryopreservation Procedures for Rat and Human Hepatocytes

1989 • 165 citations

Inhibition of tissue factor/factor VIIa activity in plasma requires factor X and an additional plasma component

1985 • 155 citations

Inhibition of factor VIIa/tissue factor-induced blood coagulation: with particular emphasis upon a factor Xa-dependent inhibitory mechanism

1989 • 141 citations

Isolation of the tissue factor inhibitor produced by HepG2 hepatoma cells.

1987 • 100 citations

7-ethoxycoumarin deethylase activity as a convenient measure of liver drug metabolizing enzymes: Regulation in cultured rat hepatocytes

1984 • 98 citations

Inhibitor of the factor VIIa-tissue factor complex is reduced in patients with disseminated intravascular coagulation but not in patients with severe hepatocellular disease.

1987 • 80 citations

Modifications of extrinsic pathway inhibitor (EPI) and factor Xa that affect their ability to interact and to inhibit factor VIIa/tissue factor: evidence for a two-step model of inhibition.

1988 • 72 citations

Biosynthesis and secretion of functional protein S by a human megakaryoblastic cell line (MEG-01)

1987 • 67 citations

Isolation and Culture of Human Intestinal Smooth Muscle Cells

1984 • 52 citations

Identification of the 1.4 KB and 4.0 KB messages for the lipoprotein associated coagulation inhibitor and expression of the encoded protein

1989 • 46 citations

Expression of tissue factor and factor VIIa/tissue factor inhibitor activity in endotoxin or phorbol ester stimulated U937 monocyte-like cells

1988 • 46 citations

Human plasma extrinsic pathway inhibitor activity: II. Plasma levels in disseminated intravascular coagulation and hepatocellular disease

1989 • 45 citations

Studies of the Factor Xa-Dependent Inhibitor of Factor VIIa/Tissue Factor (Extrinsic Pathway Inhibitor) from Cell Supernates of Cultured Human Umbilical Vein Endothelial Cells

1989 • 45 citations

Molecular defect in factor IXBm Lake Elsinore. Substitution of Ala390 by Val in the catalytic domain.

1988 • 28 citations

Inhibition of Neutrophil Functions by Platelets and Platelet-Derived Products: Description of Multiple Inhibitory Properties

1988 • 28 citations

The inhibitor of F VIIa in plasma measured with a sensitive chromogenic substrate assay: comparison with antithrombin, protein C and heparin cofactor II in a clinical material.

1988 • 4 citations