The danger of metabolic pathways with turbo design

On the nature of allosteric transitions: A plausible model

1965 • 8,699 citations

A Linear Steady-State Treatment of Enzymatic Chains. General Properties, Control and Effector Strength

1974 • 1,378 citations

Understanding the control of metabolism

1997 • 1,265 citations

A hierarchy of ATP-consuming processes in mammalian cells

1995 • 830 citations

The control of flux

1995 • 578 citations

Trehalose synthase: guard to the gate of glycolysis in yeast?

1995 • 432 citations

Thermodynamics and Control of Biological Free-Energy Transduction

1987 • 403 citations

Trehalose‐6‐phosphate, a new regulator of yeast glycolysis that inhibits hexokinases

1993 • 323 citations

Antonie van Leeuwenhoek

2013 • 260 citations

Phosphorus-31 nuclear magnetic resonance studies of wild-type and glycolytic pathway mutants of Saccharomyces cerevisiae

1979 • 257 citations

Fermentation pathway kinetics and metabolic flux control in suspended and immobilized Saccharomyces cerevisiae

1990 • 243 citations

Characterization of the 56‐kDa subunit of yeast trehalose‐6‐phosphate synthase and cloning of its gene reveal its identity with the product of CIF1, a regulator of carbon catabolite inactivation

1992 • 222 citations

Energy Requirements for Maltose Transport in Yeast

1977 • 215 citations

Glycolysis in Bloodstream Form Trypanosoma brucei Can Be Understood in Terms of the Kinetics of the Glycolytic Enzymes

1997 • 207 citations

Cloning of two related genes encoding the 56-kDa and 123-kDa subunits of trehalose synthase from the yeast Saccharomyces cerevisiae

1993 • 156 citations

The growth and signalling defects of the ggs1 (fdp1/byp1) deletion mutant on glucose are suppressed by a deletion of the gene encoding hexokinase PII

1993 • 154 citations

Regulation of genes encoding subunits of the trehalose synthase complex inSaccharomyces cerevisiae: novel variations of STRE-mediated transcription control?

1996 • 153 citations

Intracellular Glucose Concentration in Derepressed Yeast Cells Consuming Glucose Is High Enough To Reduce the Glucose Transport Rate by 50%

1998 • 149 citations

A yeast homologue of the bovine lens fibre MIP gene family complements the growth defect of a Saccharomyces cerevisiae mutant on fermentable sugars but not its defect in glucose-induced RAS-mediated cAMP signalling.

1991 • 143 citations

Evidence for trehalose‐6‐phosphate‐dependent and ‐independent mechanisms in the control of sugar influx into yeast glycolysis

1996 • 128 citations

Molecular cloning of a gene involved in glucose sensing in the yeast Saccharomyces cerevisiae

1993 • 124 citations

Genetic analysis of the pyruvate decarboxylase reaction in yeast glycolysis

1982 • 112 citations

Modular analysis of the control of complex metabolic pathways

1993 • 94 citations

The control of trehalose biosynthesis in Saccharomyces cerevisiae: Evidence for a catabolite inactivation and repression of trehalose‐6‐phosphate synthase and trehalose‐6‐phosphate phosphatase

1991 • 88 citations

Theoretical Approaches to the Evolutionary Optimization of Glycolysis

1997 • 86 citations

Control of glycolytic gene expression in the budding yeast (Saccharomyces cerevisiae)

1995 • 83 citations

Theoretical Approaches to the Evolutionary Optimization of Glycolysis

1997 • 77 citations

Isolation of a Regulatory Mutant of Fructose-1, 6-diphosphatase in Saccharomyces carlsbergensis

1974 • 74 citations

Regulation of the trehalose-6-phosphate synthase complex in Saccharomyces

1987 • 73 citations

Purification of trehalose synthase from baker's yeast

1993 • 70 citations

Substrate synergism and the kinetic mechanism of yeast hexokinase

1982 • 68 citations

Metabolic regulation: A control analytic perspective

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Transport by the lactose permease of Escherichia coli as the basis of lactose killing

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On Substrate-accelerated Death in Klebsiella aerogenes

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In vivo investigations of glucose transport in Saccharomyces cerevisiae

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Acceleration of Bacterial Death by Growth Substrates

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SCAMP: A metabolic simulator and control analysis program

1991 • 50 citations

Regulation and control of compartmentalized glycolysis in bloodstream formTrypanosoma brucei

1995 • 46 citations

Glucose-induced regulatory defects in the Saccharomyces cerevisiae byp1 growth initiation mutant and identification of MIG1 as a partial suppressor

1992 • 44 citations

Substrate‐accelerated death of Saccharomyces cerevisiae CBS 8066 under maltose stress

1990 • 42 citations

Genetic and physiological evidence for the existence of a second glycolytic pathway in yeast parallel to the phosphofructokinase-aldolase reaction sequence

1984 • 42 citations

Disruption of the Kluyveromyces lactis GGS1 gene causes inability to grow on glucose and fructose and is suppressed by mutations that reduce sugar uptake

1993 • 42 citations

TEMPORAL AND SPATIAL ORDER IN BIOCHEMICAL SYSTEMS

1979 • 36 citations

Metabolism and thermotolerance function of trehalose in Saccharomyces: a current perspective

1990 • 24 citations

Characterization of 3': 5'-Cyclic AMP Phosphodiesterase in Klebsiella aerogenes and its Role in Substrate-accelerated Death

1981 • 23 citations

The intracellular equilibrium thermodynamic and steady-state concentrations of metabolites

1988 • 9 citations