Physicochemical and biological characterisation of an antisense oligonucleotide targeted against the bcl-2 mRNA complexed with cationic–hydrophilic copolymers

PEGylated DNA/transferrin–PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery

1999 • 1,165 citations

BCL-2 antisense therapy in patients with non-Hodgkin lymphoma

1997 • 502 citations

Long-circulating (sterically stabilized) liposomes for targeted drug delivery

1994 • 449 citations

A placebo-controlled trial of ICAM-1 antisense oligonucleotide in the treatment of Crohn's disease

1998 • 386 citations

Characterization of Vectors for Gene Therapy Formed by Self-Assembly of DNA with Synthetic Block Co-Polymers

1996 • 365 citations

Interactions of polymeric and liposomal gene delivery systems with extracellular glycosaminoglycans: physicochemical and transfection studies

1999 • 342 citations

Spontaneous Formation of Polyion Complex Micelles with Narrow Distribution from Antisense Oligonucleotide and Cationic Block Copolymer in Physiological Saline

1996 • 298 citations

Water-Soluble Block Polycations as Carriers for Oligonucleotide Delivery

1995 • 249 citations

Novel vectors for gene delivery formed by self-assembly of DNA with poly(l-lysine) grafted with hydrophilic polymers

1998 • 247 citations

Self-Assembly of Polyamine−Poly(ethylene glycol) Copolymers with Phosphorothioate Oligonucleotides

1998 • 241 citations

Remarkable Increase in Nuclease Resistance of Plasmid DNA through Supramolecular Assembly with Poly(ethylene glycol)–Poly(l-lysine) Block Copolymer

1998 • 233 citations

Cationic Liposomes Coated with Polyethylene Glycol As Carriers for Oligonucleotides

1998 • 214 citations

Specific inhibition of hepatitis B viral gene expression in vitro by targeted antisense oligonucleotides.

1992 • 183 citations

Naked DNA delivered intraportally expresses efficiently in hepatocytes.

1996 • 171 citations

Biological activity of oligonucleotide-poly(L-lysine) conjugates: mechanism of cell uptake

1990 • 160 citations

Decreased Binding to Proteins and Cells of Polymeric Gene Delivery Vectors Surface Modified with a Multivalent Hydrophilic Polymer and Retargeting through Attachment of Transferrin

2000 • 157 citations

Atomic force microscopic analysis of the influence of the molecular weight of poly(L)lysine on the size of polyelectrolyte complexes formed with DNA.

1996 • 153 citations

Pharmacokinetics of antisense oligodeoxyribonucleotides (cyclin B1 and CDC 2 kinase) in the vessel wall in vivo: enhanced therapeutic utility for restenosis by HVJ-liposome delivery

1994 • 153 citations

Inhibition of leukemia cell proliferation by receptor-mediated uptake of c-myb antisense oligodeoxynucleotides.

1992 • 145 citations

Structural requirements for the binding of ethidium to nucleic acids

1966 • 142 citations

Phase I trial of an antisense oligonucleotide OL(1)p53 in hematologic malignancies.

1996 • 140 citations

N-(2-Hydroxypropyl)methacrylamide copolymers targeted to the hepatocyte galactose-receptor: pharmacokinetics in DBA2 mice

1991 • 116 citations

Amphiphysin I Antisense Oligonucleotides Inhibit Neurite Outgrowth in Cultured Hippocampal Neurons

1998 • 101 citations

Physicochemical and disposition characteristics of antisense oligonucleotides complexed with glycosylated poly(l-lysine)

1997 • 94 citations

Synthetic polymers for vectorial delivery of DNA: characterisation of polymer-DNA complexes by photon correlation spectroscopy and stability to nuclease degradation and disruption by polyanions in vitro

1997 • 90 citations

DNA complexes with block and graft copolymers of N-(2-hydroxypropyl)methacrylamide and 2-(trimethylammonio)ethyl methacrylate

1999 • 64 citations

Reduction of fibronectin expression by intravitreal administration of antisense oligonucleotides

1999 • 59 citations

Antisense oligonucleotides as inhibitors of signal transduction: development from research tools to therapeutic agents

1996 • 42 citations

Gene transcription: DNA binding proteins

1997 • 9 citations