Interleukin-1 and Tumor Necrosis Factor Receptor Signaling Is Not Required for Bacteria-Induced Osteoclastogenesis and Bone Loss but Is Essential for Protecting the Host from a Mixed Anaerobic Infection

Biologic basis for interleukin-1 in disease

1996 • 4,324 citations

The effects of surgical exposures of dental pulps in germ-free and conventional laboratory rats

1965 • 2,271 citations

Common themes in microbial pathogenicity revisited

1997 • 1,370 citations

Two TNF receptors

1992 • 1,048 citations

TUMOR NECROSIS FACTOR: A Pleiotropic Cytokine and Therapuetic Target

1994 • 1,047 citations

Interleukin 1 induces a shock-like state in rabbits. Synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition.

1988 • 990 citations

Neutrophils, host defense, and inflammation: a double-edged sword

1994 • 807 citations

TNF Receptor-Deficient Mice Reveal Divergent Roles for p55 and p75 in Several Models of Inflammation

1998 • 715 citations

Role of cytokines and inflammatory mediators in tissue destruction

1993 • 611 citations

IL-1 and TNF Antagonists Inhibit the Inflammatory Response and Bone Loss in Experimental Periodontitis

1998 • 596 citations

Synergistic interactions between interleukin 1, tumor necrosis factor, and lymphotoxin in bone resorption.

1987 • 527 citations

Role of Lymphotoxin and the Type I TNF Receptor in the Formation of Germinal Centers

1996 • 386 citations

The type II ‘decoy’ receptor: A novel regulatory pathway for interleukin 1

1994 • 382 citations

Phenotypic and functional characterization of mice that lack the type I receptor for IL-1.

1997 • 370 citations

Influence of combinations of oral bacteria on periapical tissues of monkeys

1982 • 312 citations

Lipopolysaccharide-stimulated osteoclastogenesis is mediated by tumor necrosis factor via its P55 receptor.

1997 • 277 citations

Simultaneous block of interleukin-1 and tumor necrosis factor is required to completely prevent bone loss in the early postovariectomy period.

1995 • 257 citations

Recent advances in bone biology provide insight into the pathogenesis of bone diseases.

1999 • 147 citations

Killing of Staphylococcus aureus by tumor necrosis factor-alpha-activated neutrophils. The role of serum opsonins, integrin receptors, respiratory burst, and degranulation.

1993 • 92 citations

Monocyte recruitment and expression of monocyte chemoattractant protein-1 are developmentally regulated in remodeling bone in the mouse.

1997 • 72 citations

Bone‐resorptive cytokine gene expression in periapical lesions in the rat

1997 • 68 citations

Control of Osteoclast Differentiation

1998 • 67 citations

The exposed germ-free pulp: Effects of topical corticosteroid medication and restoration

1969 • 49 citations

Staphylococcus aureus-stimulated mononuclear leucocyte-conditioned medium increases the neutrophil bactericidal activity, and augments oxygen radical production and degranulation in response to the bacteria.

1989 • 12 citations

Cellular and Molecular Mechanisms of Cytokine Networking

1991 • 8 citations