Toward the rational design of protein kinase casein kinase-2 inhibitors

Specificity and mechanism of action of some commonly used protein kinase inhibitors

2000 • 4,109 citations

Oncogenic kinase signalling

2001 • 3,632 citations

Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification.

1995 • 2,534 citations

The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification ¹

1995 • 2,199 citations

Structural Mechanism for STI-571 Inhibition of Abelson Tyrosine Kinase

2000 • 1,770 citations

Casein kinase 2: An ‘eminence grise’ in cellular regulation?

1990 • 920 citations

Herbal drugs and phytopharmaceuticals

1994 • 463 citations

Casein Kinase IIα Transgene-Induced Murine Lymphoma: Relation to Theileriosis in Cattle

1995 • 384 citations

Strategies toward the Design of Novel and Selective Protein Tyrosine Kinase Inhibitors

1999 • 366 citations

Isolation, sequencing, and disruption of the yeast CKA2 gene: casein kinase II is essential for viability in Saccharomyces cerevisiae.

1990 • 365 citations

Selectivity of 4,5,6,7‐tetrabromobenzotriazole, an ATP site‐directed inhibitor of protein kinase CK2 (‘casein kinase‐2’)

2001 • 346 citations

Inhibition of casein kinase II by heparin.

1980 • 341 citations

Protein kinase CK2 (“casein kinase-2”) and its implication in cell division and proliferation

1997 • 320 citations

Casein kinase type II is involved in the inhibition by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole of specific RNA polymerase II transcription.

1986 • 285 citations

Protein kinase CK2 signal in neoplasia.

2001 • 262 citations

Crystal structure of the catalytic subunit of protein kinase CK2 from Zea mays at 2.1Aresolution

1998 • 198 citations

Differential effects of flavonoids as inhibitors of tyrosine protein kinases and serine/threonine protein kinases

1988 • 193 citations

GTP plus water mimic ATP in the active site of protein kinase CK2.

1999 • 178 citations

The effect of quercetin on the phosphorylatio activity of the Rous sarcoma virus transforming gene product in vitro and in vivo

1983 • 177 citations

Emodin, an Anthraquinone Derivative Isolated from the Rhizomes of Rheum palmatum, Selectively Inhibits the Activity of Casein Kinase II as a Competitive Inhibitor

1999 • 160 citations

Structural features underlying selective inhibition of protein kinase CK2 by ATP site‐directed tetrabromo‐2‐benzotriazole

2001 • 154 citations

Endogenous phosphate acceptor proteins for rat liver cytosolic casein kinases.

1981 • 153 citations

The Replacement of ATP by the Competitive Inhibitor Emodin Induces Conformational Modifications in the Catalytic Site of Protein Kinase CK2

2000 • 148 citations

Substrate specificity of protein kinase CK2.

1994 • 145 citations

Inhibition of the calcium- and phospholipid-dependent protein kinase activity from mouse brain cytosol by quercetin

1983 • 142 citations

Structure of the protein tyrosine kinase domain of C-terminal Src kinase (CSK) in complex with staurosporine 1 1Edited by I. A. Wilson

1999 • 138 citations

Halogenated Benzimidazoles and Benzotriazoles as Selective Inhibitors of Protein Kinases CK-I and CK-II from Saccharomyces Cerevisiae and Other Sources

1995 • 127 citations

Protein Kinase CK2 Mutants Defective in Substrate Recognition

1996 • 124 citations

Protein Kinase CK2α′ Is Induced by Serum as a Delayed Early Gene and Cooperates with Ha-ras in Fibroblast Transformation

1998 • 118 citations

Tyrosine kinase inhibitors, emodin and its derivative repress HER-2/neu-induced cellular transformation and metastasis-associated properties

1998 • 118 citations

Inhibition of phosphorylase kinase, and tyrosine protein kinase activities by quercetin

1985 • 118 citations

Ribofuranosyl‐benzimidazole derivatives as inhibitors of casein kinase‐2 and casein kinase‐1

1990 • 115 citations

Selective inhibition of a cyclic nucleotide independent protein kinase (G type casein kinase) by quercetin and related polyphenols

1982 • 102 citations

Expression and localization of epitope-tagged protein kinase CK2

1997 • 76 citations

Selective Inhibition of the Growth of ras-Transformed Human Bronchial Epithelial Cells by Emodin, a Protein-Tyrosine Kinase Inhibitor

1993 • 72 citations

A role for protein kinase CK2 in cell proliferation: evidence using a kinase-inactive mutant of CK2 catalytic subunit α

2001 • 68 citations

Regulation of casein kinase II by growth factors: a reevaluation.

1994 • 68 citations

Tyrosine Versus Serine/Threonine Phosphorylation by Protein Kinase Casein Kinase-2

1999 • 63 citations

A historical view of protein kinase CK2.

1994 • 54 citations

Mutational Analysis of Residues Implicated in the Interaction between Protein Kinase CK2 and Peptide Substrates

1997 • 52 citations

Significance of the casein kinase system in cell growth and proliferation with emphasis on studies of the androgenic regulation of the prostate.

1994 • 36 citations

Cooperative Modulation of Protein Kinase CK2 by Separate Domains of Its Regulatory β-Subunit

2000 • 29 citations

Random tyrosine and glutamic acid-containing polymers are very powerful inhibitors of casein kinase-2

1989 • 26 citations

A multifunctional network of basic residues confers unique properties to protein kinase CK2.

1999 • 20 citations