Ultrastructural localization of amyloid β/A4 protein precursor in the normal rat brain

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1991 • 4,533 citations

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

1985 • 4,276 citations

Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor

1990 • 1,388 citations

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein

1989 • 1,237 citations

Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene

1991 • 1,191 citations

A mutation in the Amyloid Precursor Protein Associated with Hereditary Alzheimer's Disease

1991 • 1,121 citations

Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity

1988 • 1,093 citations

Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments

1992 • 883 citations

Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

1992 • 737 citations

Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues.

1988 • 584 citations

An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P.

1991 • 516 citations

Alzheimer's disease amyloidogenic glycoprotein: expression pattern in rat brain suggests a role in cell contact.

1988 • 444 citations

Expression of β amyloid protein precursor mRNAs: Recognition of a novel alternatively spliced form and quantitation in alzheimer's disease using PCR

1990 • 426 citations

Expression of the Alzheimer amyloid precursor gene transcripts in the human brain

1988 • 386 citations

Expression of β-amyloid precursor protein in reactive astrocytes following neuronal damage

1989 • 345 citations

Localization of Amyloid β Protein Messenger RNA in Brains from Patients with Alzheimer's Disease

1987 • 297 citations

The Alzheimer amyloid precursor protein. Identification of a stable intermediate in the biosynthetic/degradative pathway.

1990 • 283 citations

Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion

1991 • 276 citations

Localization of Alzheimer βA4 amyloid precursor protein at central and peripheral synaptic sites

1991 • 259 citations

Effects of injected Alzheimer beta-amyloid cores in rat brain.

1991 • 255 citations

Neuronal localization of amyloid beta protein precursor mRNA in normal human brain and in Alzheimer's disease.

1987 • 222 citations

Immunocytochemical localization of the precursor protein for β-amyloid in the rat central nervous system

1988 • 153 citations

Expression of APP in the early stage of brain damage

1991 • 152 citations

The amyloid precursor protein is concentrated in neuronal lysosomes in normal and Alzheimer disease subjects

1989 • 142 citations

Evidence for lysosomal processing of amyloid ?-protein precursor in cultured cells

1989 • 114 citations

Amyloid beta protein precursor is a mitogen

1989 • 105 citations

CELLULAR LOCALIZATION OF MESSENGER RNA ENCODING AMYLOID-BETA-PROTEIN IN NORMAL TISSUE AND IN ALZHEIMER DISEASE

1988 • 104 citations

Distribution of precursor amyloid-beta-protein messenger RNA in human cerebral cortex: relationship to neurofibrillary tangles and neuritic plaques.

1988 • 101 citations

Amyloid β-protein precursor accumulates in dystrophic neurites of senile plaques in Alzheimer-type dementia

1990 • 100 citations

Neuroanatomical localization and quantification of amyloid precursor protein mRNA by in situ hybridization in the brains of normal, aneuploid, and lesioned mice.

1988 • 85 citations

Ultrastructure of diffuse plaques in senile dementia of the Alzheimer type: comparison with primitive plaques

1991 • 72 citations

Immunoelectron microscopic localization of amyloid β protein in the diffuse plaques of Alzheimer-type dementia

1990 • 69 citations

Secondary deposition of beta amyloid within extracellular neurofibrillary tangles in Alzheimer-type dementia.

1991 • 68 citations

Topographical relationship between beta-amyloid and tau protein epitopes in tangle-bearing cells in Alzheimer disease.

1990 • 64 citations

Amyloid β/A4 protein precursor is widely distributed in both the central and peripheral nervous systems of the mouse

1991 • 58 citations

The amyloid β-protein precursor is localized in smooth muscle cells of leptomeningeal vessels

1990 • 54 citations

Post-embedding electron microscopic immunocytochemistry

1992 • 48 citations

Amyloid β/A4 protein precursor is bound to neurofibrillary tangles in Alzheimer-type dementia

1990 • 46 citations

Electron microscopic immunocytochemistry : principles and practice

1992 • 45 citations

Alzheimer amyloid beta-protein precursor in sperm development.

1990 • 23 citations

Subpial β/A4 amyloid deposition occurs between astroglial processes in Alzheimer-type dementia

1991 • 20 citations

Spiny and aspiny types of neuropeptide Y immunoreactive neurons in the monkey neostriatum

1991 • 4 citations

Deleted Work

1955 • 0 citations