Neocarzinostatin acts as a sensitive probe of DNA microheterogeneity: switching of chemistry from C-1' to C-4' by a G.T mismatch 5' to the site of DNA damage.

DNA MISMATCH CORRECTION

1987 • 427 citations

Bleomycin-induced strand-scission of DNA. Mechanism of deoxyribose cleavage.

1981 • 415 citations

Interaction of bleomycin with DNA.

1978 • 250 citations

Molecular structure of the G.A base pair in DNA and its implications for the mechanism of transversion mutations.

1986 • 216 citations

The structure of guanosine-thymidine mismatches in B-DNA at 2.5-A resolution.

1987 • 177 citations

Nuclease activity of 1,10-phenanthroline-copper ion: reaction with CGCGAATTCGCG and its complexes with netropsin and EcoRI

1986 • 173 citations

Bleomycin-induced DNA lesions at mutational hot spots: implications for the mechanism of double-strand cleavage.

1990 • 142 citations

G · T base-pairs in a DNA helix: The crystal structure of d(G-G-G-G-T-C-C-C)

1985 • 108 citations

Wobble dG.cntdot.dT pairing in right-handed DNA: solution conformation of the d(C-G-T-G-A-A-T-T-C-G-C-G) duplex deduced from distance geometry analysis of nuclear Overhauser effect spectra

1986 • 103 citations

Identification of 2-deoxyribonolactone at the site of neocarzinostatin-induced cytosine release in the sequence d(AGC)

1989 • 90 citations

Chemistry of the alkali-labile lesion formed from iron(II) bleomycin and d(CGCTTTAAAGCG)

1988 • 83 citations

Endonuclease-resistant apyrimidinic sites formed by neocarzinostatin at cytosine residues in DNA: evidence for a possible role in mutagenesis.

1985 • 78 citations

Activation of neocarzinostatin chromophore and formation of nascent DNA damage do not require molecular oxygen

1985 • 69 citations

Neocarzinostatin-induced hydrogen atom abstraction from C-4' and C-5' of the T residue at a d(GT) step in oligonucleotides: shuttling between deoxyribose attack sites based on isotope selection effects

1991 • 61 citations

Atypical abasic sites generated by neocarzinostatin at sequence-specific cytidylate residues in oligodeoxynucleotides

1988 • 60 citations

Neocarzinostatin-mediated DNA damage in a model AGT.cntdot.ACT site: mechanistic studies of thiol-sensitive partitioning of C4' DNA damage products

1992 • 58 citations

Sequence-specific double-strand breakage of DNA by neocarzinostatin involves different chemical mechanisms within a staggered cleavage site.

1990 • 55 citations

Dynamics of DNA duplexes containing internal G.T, G.A, A.C, and T.C pairs: hydrogen exchange at and adjacent to mismatch sites.

1984 • 52 citations

Neocarzinostatin-induced DNA base release accompanied by staggered oxidative cleavage of the complementary strand.

1988 • 48 citations

Influence of thiol structure on neocarzinostatin activation and expression of DNA damage

1992 • 43 citations

Base substitution mutations induced in the cI gene of lambda phage by neocarzinostatin chromophore: correlation with depyrimidination hotspots at the sequence AGC

1986 • 38 citations

Molecular models of neocarzinostatin damage of DNA: analysis of sequence dependence in 5′GAGCG:5′CGCTC

1990 • 36 citations

Selective abstraction of 2H from C-5' of thymidylate in an oligodeoxynucleotide by the radical center at C-6 of the diradical species of neocarzinostatin: chemical evidence for the structure of the activated drug-DNA complex.

1991 • 32 citations