Nicotine physical dependence and tolerance in the mouse following chronic oral administration

A METHOD FOR DETERMINING LOSS OF PAIN SENSATION

1941 • 3,174 citations

Synthetic analgesics. II. Dithienylbutenyl- and dithienylbutylamines.

1953 • 1,702 citations

Dramatic decreases in brain reward function during nicotine withdrawal

1998 • 676 citations

A major role for CYP2A6 in nicotine C-oxidation by human liver microsomes.

1997 • 440 citations

The effect of various neurohumoral modulators on the activity of morphine and the narcotic antagonists in the tail-flick and phenylquinone tests.

1970 • 339 citations

Rodent model of nicotine abstinence syndrome

1992 • 326 citations

Time course study of the effects of chronic nicotine infusion on drug response and brain receptors.

1985 • 271 citations

Characterization of Spontaneous and Precipitated Nicotine Withdrawal in the Mouse

2003 • 206 citations

Effects of continuous oral nicotine administration on brain nicotinic receptors and responsiveness to nicotine in C57Bl/6 mice

1999 • 185 citations

A high-performance liquid-chromatographic method for routine simultaneous determination of nicotine and cotinine in plasma.

1988 • 178 citations

Nicotine dependence

2001 • 170 citations

The nicotinic antagonist mecamylamine precipitates nicotine abstinence syndrome in the rat

1994 • 168 citations

A high-performance liquid-chromatographic method for routine simultaneous determination of nicotine and cotinine in plasma.

1988 • 151 citations

The nicotinic antagonist methyllycaconitine has differential effects on nicotine self-administration and nicotine withdrawal in the rat

2001 • 147 citations

Behavioral and Biochemical Manifestations of Mecamylamine-Precipitated Nicotine Withdrawal in the Rat Role of Nicotinic Receptors in the Ventral Tegmental Area

1999 • 102 citations

Nicotine abstinence in the mouse

1999 • 96 citations

Regulation of nicotinic receptors in the brain of mice withdrawn from chronic oral nicotine treatment

1998 • 67 citations

The development of cross-tolerance between morphine and nicotine in mice

1999 • 64 citations

In vivo pharmacological effects of dihydro-β-erythroidine, a nicotinic antagonist, in mice

1995 • 64 citations

Effects of chronic oral nicotine treatment and its withdrawal on locomotor activity and brain monoamines in mice

2000 • 60 citations

The analgesic and sedative effects of nicotine in white mice, rabbits and golden hamsters.

1968 • 56 citations

Antinociceptive effect of chronic nicotine and nociceptive effect of its withdrawal measured by hot-plate and tail-flick in rats

1992 • 53 citations

Analgesia induced by chronic nicotine infusion in rats

2001 • 52 citations

Nicotine Abstinence Syndrome Precipitated by the Competitive Nicotinic Antagonist Dihydro-β-Erythroidine

1998 • 50 citations

Chronic Nicotine Administration in the Drinking Water Affects the Striatal Dopamine in Mice

2000 • 50 citations

Nicotine Abstinence Syndrome Precipitated by Central But Not Peripheral Hexamethonium

1997 • 43 citations

The anxiolytic-like effect of nicotine undergoes rapid tolerance in a model of contextual fear conditioning in rats

2001 • 43 citations

Chronic oral nicotine administration affects the circadian rhythm of dopamine and 5-hydroxytryptamine metabolism in the striata of mice

1995 • 39 citations

Characterization and modulation of acute tolerance to nicotine in mice.

1996 • 30 citations

Changes in sensitivity to nicotine and brain nicotinic receptors following chronic nicotine and corticosterone treatments in mice

1996 • 28 citations

Tolerance to the antinociceptive effect of epibatidine after acute and chronic administration in mice

1996 • 24 citations

Mecamylamine blocks the development of tolerance to nicotine in rats: implications for the mechanisms of tolerance

1999 • 24 citations

Tolerance to the Convulsions Induced by Daily Nicotine Treatment in Rats

1992 • 14 citations

SYNTHETIC ANALGESICS: II. DITHIENY BUTENYL-AND BENZOMORPHANS

1953 • 13 citations

The effects of acute nicotine on the body temperature and striatal dopamine metabolism of mice during chronic nicotine infusion

2000 • 13 citations