Oxidation of LDL: Role in atherogenesis

Beyond Cholesterol

1989 • 6,533 citations

The Low-Density Lipoprotein Pathway and its Relation to Atherosclerosis

1977 • 2,481 citations

LIPOPROTEIN METABOLISM IN THE MACROPHAGE: Implications for Cholesterol Deposition in Atherosclerosis

1983 • 2,306 citations

Book ReviewAmbulatory Pediatric Care

1989 • 2,075 citations

Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man.

1989 • 1,914 citations

The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions.

1981 • 1,325 citations

Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit.

1987 • 1,051 citations

Endothelial and smooth muscle cells alter low density lipoprotein in vitro by free radical oxidation.

1984 • 826 citations

Probucol inhibits oxidative modification of low density lipoprotein.

1986 • 633 citations

Role of oxidatively modified LDL in atherosclerosis

1990 • 614 citations

A macrophage receptor that recognizes oxidized low density lipoprotein but not acetylated low density lipoprotein

1989 • 480 citations

Modification of human serum low density lipoprotein by oxidation — Characterization and pathophysiological implications

1987 • 400 citations

Modification of low density lipoprotein with 4-hydroxynonenal induces uptake by macrophages.

1989 • 186 citations

Fatty streaks in the coronary arteries and aorta.

1968 • 169 citations

Distribution of plasma proteins across the human aortic wall Barrier functions of endothelium and internal elastic lamina

1980 • 168 citations

Control of monocyte recruitment by chemotactic factor(s) in lesion-prone areas of swine aorta.

1985 • 163 citations

Lesion-derived low density lipoprotein and oxidized low density lipoprotein share a lability for aggregation, leading to enhanced macrophage degradation.

1991 • 158 citations

Recent advances in molecular pathology

1984 • 150 citations

Isolation, purification, and characterization of a lipoprotein containing apo B from the human aorta

1982 • 135 citations

Oxidation of low density lipoprotein leads to particle aggregation and altered macrophage recognition.

1992 • 134 citations

Characterization of the adhesion of the human monocytic cell line U937 to cultured endothelial cells.

1985 • 123 citations

Cholesterol esterification in macrophages. Stimulation by lipoproteins containing apo B isolated from human aortas.

1984 • 107 citations

A low density lipoprotein-sized particle isolated from human atherosclerotic lesions is internalized by macrophages via a non-scavenger-receptor mechanism.

1990 • 87 citations

Modified plasma-derived lipoproteins in human atherosclerotic plaques

1988 • 65 citations

Apo B concentration in the normal human aorta

1978 • 45 citations

Macrophage uptake of low-density lipoprotein modified by 4-hydroxynonenal. An ultrastructural study.

1991 • 28 citations

Ultrastructural localization of apolipoprotein B in human aortic and coronary atherosclerotic plaques

1977 • 26 citations

Modified low density lipoprotein isolated from atherosclerotic lesions does not cause lipid accumulation in aortic smooth muscle cells.

1991 • 17 citations