Allosteric Behavior in Cytochrome P450-Dependent in Vitro Drug−Drug Interactions: A Prospective Based on Conformational Dynamics

On the nature of allosteric transitions: A plausible model

1965 • 8,699 citations

The P450 Superfamily: Update on New Sequences, Gene Mapping, Accession Numbers, Early Trivial Names of Enzymes, and Nomenclature

1993 • 1,663 citations

CYTOCHROME P-450 3A4: Regulation and Role in Drug Metabolism

1999 • 1,235 citations

The Human Hepatic Cytochromes P450 Involved in Drug Metabolism

1992 • 932 citations

Cytochrome P450

1995 • 582 citations

Activation of CYP3A4: Evidence for the Simultaneous Binding of Two Substrates in a Cytochrome P450 Active Site

1994 • 348 citations

Molecular Code for Cooperativity in Hemoglobin

1992 • 322 citations

Sigmoidal kinetic model for two co-operative substrate-binding sites in a cytochrome P450 3A4 active site: an example of the metabolism of diazepam and its derivatives

1999 • 143 citations

Differential Mechanisms of Cytochrome P450 Inhibition and Activation by α-Naphthoflavone

1997 • 130 citations

Molecular modeling of cytochrome P450 3A4.

1997 • 129 citations

Homotropic effects in aspartate transcarbamoylase

1985 • 59 citations