Decrease in brain NE turnover after chronic DMI treatment; no effect with iprindole

Norepinephrine in Depressive Reactions

1965 • 1,127 citations

ELUCIDATION OF THE RATE-LIMITING STEP IN NOREPINEPHRINE BIOSYNTHESIS IN THE PERFUSED GUINEA-PIG HEART.

1965 • 1,002 citations

Biogenic Amines and Emotion

1967 • 878 citations

Fluorescence assay in biology and medicine

1962 • 772 citations

INTENSIFICATION OF THE CENTRAL SEROTONINERGIC PROCESSES AS A POSSIBLE DETERMINANT OF THE THYMOLEPTIC EFFECT

1969 • 705 citations

The fluorometric assay of catecholamines and related compounds: Improvements and extensions to the hydroxyindole technique

1968 • 693 citations

Simultaneous measurement of tyrosine and tryptophan hydroxylase activities in brain in Vivo using an inhibitor of the aromatic amino acid decarboxylase

1972 • 649 citations

Fluorescence Assay in Biology and Medicine

1963 • 642 citations

A sensitive method for spectrophotofluorometric assay of catecholamines

1964 • 557 citations

Inhibition of Uptake of Tritiated-noradrenaline in the Intact Rat Brain by Imipramine and Structurally Related Compounds

1964 • 506 citations

The fate of H3-norepinephrine in animals.

1961 • 431 citations

Biochemical and Histochemical Studies on the Effects of Imipramine‐like Drugs and (+)‐Amphetamine on Central and Peripheral Catecholamine Neurons

1966 • 414 citations

Brain Catechol Synthesis: Control by Brain Tyrosine Concentration

1974 • 367 citations

Catecholamine Metabolism, Depressive Illness, and Drug Response

1972 • 341 citations

Regional studies of catecholamines in the rat brain. IV. Effects of drugs on the disposition and metabolism of H3-norepinephrine and H3-dopamine.

1966 • 307 citations

Selective release of newly synthesized norepinephrine from the cat spleen during sympathetic nerve stimulation.

1968 • 242 citations

Catecholamine metabolism in affective disorders—III

1970 • 239 citations

Regulation of Norepinephrine Biosynthesis

1970 • 231 citations

The effect of imipramine-like drugs and antihistamine drugs on uptake mechanisms in the central noradrenaline and 5-hydroxytryptamine neurons

1971 • 220 citations

The effect of imipramine of central 5-hydroxytryptamine neurons

1968 • 198 citations

Importance of fundamental principles in drug evaluation

1968 • 196 citations

A simple procedure for calculating the synthesis rate of norepinephrine, dopamine and serotonin in rat brain.

1971 • 183 citations

Effects of drugs on the disposition of H-3-norepinephrine in the rat brain.

1966 • 175 citations

Histochemical studies on the effect of (+)-amphetamine, drugs of the imipramine group and tryptamine on central catecholamine and 5-hydroxytryptamine neurons after intraventricular injection of catecholamines and 5-hydroxytryptamine

1968 • 173 citations

The rate of norepinephrine synthesis measured in vivo during short intervals; influence of adrenergic nerve impulse activity.

1968 • 172 citations

The effects of psychoactive drugs on norepinephrine-3H metabolism in brain

1967 • 151 citations

Catecholamine metabolism in affective disorders: I.

1965 • 135 citations

Norepinephrine Turnover and Metabolism in Rat Brain after Long-Term Administration of Imipramine

1970 • 125 citations

Effect of antidepressant drugs on accumulation and disappearance of monoamines formed in vivo from labelled precursors in mouse brain

1970 • 115 citations

Biogenic Amines and Affective Disorders

1974 • 112 citations

The pharmacology of iprindole, a new antidepressant

1969 • 111 citations

Effect of iprindole on norepinephrine turnover and transport

1974 • 93 citations

Biochemistry of simple neuronal models

1970 • 91 citations

Iprindole-amphetamine interactions in the rat: the role of aromatic hydroxylation of amphetamine in its mode of action.

1972 • 90 citations

A comparison of the inhibitory activities of iprindole and imipramine on the uptake of 5-hydroxytryptamine and noradrenaline in brain slices

1971 • 88 citations

Estimation of Turnover Rates to Study the Metabolic Regulation of the Steady-State Level of Neuronal Monoamines

1970 • 87 citations

Changes in Norepinephrine Turnover in Rat Brain During Chronic Administration of Imipramine and Protriptyline: A Possible Explanation for the Delay in Onset of Clinical Antidepressant Effects

1971 • 77 citations

EFFECT OF STRESS ON THE DISPOSITION OF CATECHOLAMINES LOCALIZED IN VARIOUS INTRANEURONAL STORAGE FORMS IN THE BRAIN STEM OF THE RAT

1971 • 67 citations

The tricyclic antidepressants—Inhibition of norepinephrine uptake as related to potentiation of norepinephrine and clinical efficacy

1971 • 59 citations

A comparison of the acute and chronic effects of four antidepressant drugs on the turnover of serotonin, dopamine and noradrenaline in the rat brain

1976 • 54 citations

The effects of chronic imipramine administration on rat brain levels of serotonin, 5-hydroxyindoleacetic acid, norepinephrine and dopamine.

1972 • 53 citations

MODE OF ACTION OF IMIPRAMINE ANID 5-(3'-METHYLAMINOPROPYLIDEN)-DIBENZO[a,e]CYCLOHEPTA[1,3,5]TRIEN HYDROCHLORIDE (RO 4-6011), A NEW ANTIDEPRESSANT DRUG, ON PERIPHERAL ADRENERGIC MECHANISMS

1964 • 52 citations

Simple neuronal models to estimate turnover rate of noradrenergic transmitters in vivo.

1970 • 44 citations

Catecholamine metabolism in affective disorders —IV. Preliminary studies of norepinephrine metabolism in depressed patients treated with amitriptyline

1972 • 43 citations

Effects of acute and chronic administration of desmethylimipramine on the content of norepinephrine and other monoamines in the rat brain

1973 • 39 citations

Effect of desmethylimipramine, iprindole and dl-erythro-α-(3,4-dichlorophenyl)-β-(t-butyl amino) propanol HCl on the metabolism of amphetamine

1970 • 39 citations

Effect of Iprindole on Amine Uptake in Man

1972 • 39 citations

Iprindole and Imipramine in Non-Psychotic Depressed Out-Patients

1973 • 30 citations

Treatment of Depressed Patients With Iprindole

1967 • 29 citations

Iprindole in Neurotic Depressed General Practice Patients: A Controlled Study

1968 • 25 citations

Use of Single Unit Recording in Correlating Transmitter Turnover with Impulse Flow in Monoamine Neurons

1973 • 21 citations

Iprindole, a new antidepressant for use in general office practice. A double blind, placebo-controlled study.

1965 • 16 citations

Methods for Measuring Indolealkylamine and Catecholamine Turnover Rate “In Vivo”

1971 • 15 citations

A preliminary investigation of WY-3263 versus amitriptyline in depressions.

1968 • 12 citations

Effects of amphetamine and its hydroxylated derivatives on newly synthesized hypothalamic norepinephrine; study in vitro

1975 • 6 citations