New Insights into the Etiology of Pre-eclampsia

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

1976 • 3,613 citations

Preeclampsia: An endothelial cell disorder

1989 • 1,848 citations

Inadequate maternal vascular response to placentation in pregnancies complicated by pre‐eclampsia and by small‐for‐gestational age infants

1986 • 1,618 citations

A Class I Antigen, HLA-G, Expressed in Human Trophoblasts

1990 • 1,417 citations

A Study of Angiotensin II Pressor Response throughout Primigravid Pregnancy

1973 • 1,230 citations

QUANTIFICATION OF CEREBRAL OXYGENATION AND HAEMODYNAMICS IN SICK NEWBORN INFANTS BY NEAR INFRARED SPECTROPHOTOMETRY

1986 • 874 citations

Distribution patterns of extracellular matrix components and adhesion receptors are intricately modulated during first trimester cytotrophoblast differentiation along the invasive pathway, in vivo.

1992 • 669 citations

Hypertensive disorders in pregnancy

1985 • 668 citations

Placental bed spiral arteries in the hypertensive disorders of pregnancy

1991 • 665 citations

Pre-eclampsia and the placenta

1991 • 592 citations

Preeclampsia is associated with abnormal expression of adhesion molecules by invasive cytotrophoblasts.

1993 • 552 citations

Epidemiology of preeclampsia and eclampsia in the United States, 1979-1986

1990 • 524 citations

Lipid peroxidation in pregnancy: New perspectives on preeclampsia

1989 • 458 citations

Vasoconstriction: A New Activity for Platelet-Derived Growth Factor

1986 • 430 citations

Molecular and cellular mechanism of endothelin regulation. Implications for vascular function.

1991 • 391 citations

The hyperlipidemia of pregnancy in normal and complicated pregnancies

1979 • 372 citations

MORPHOLOGICAL CHANGES OF THE SPIRAL ARTERIES IN THE PLACENTAE BED IN RELATION TO PRE‐ECLAMPSIA AND FETAL GROWTH RETARDATION

1981 • 370 citations

Cell biology of endothelial cells

1987 • 356 citations

Women with Preeclampsia have Higher Plasma Endothelin Levels than Women with Normal Pregnancies

1990 • 344 citations

Preeclampsia is associated with a serum factor cytotoxic to human endothelial cells

1988 • 290 citations

Genetics of hypertension in pregnancy: possible single gene control of pre‐eclampsia and eclampsia in the descendants of eclamptic women

1986 • 266 citations

The imbalance between thromboxane and prostacyclin in preeclampsia is associated with an imbalance between lipid peroxides and vitamin E in maternal blood

1991 • 260 citations

Preeclampsia: a review of the role of prostaglandins.

1988 • 255 citations

An Epidemiologic Study of Contraception and Preeclampsia

1989 • 254 citations

The placental bed biopsy: Review from three European centers

1986 • 234 citations

Preeclampsia in diabetic pregnancies

1990 • 216 citations

An abortive Pertussis infection

1982 • 213 citations

Placental lipid peroxides and thromboxane are increased and prostacyclin is decreased in women with preeclampsia

1992 • 209 citations

Maternal plasma level of endothelin is increased in preeclampsia

1991 • 203 citations

High plasma cellular fibronectin levels correlate with biochemical and clinical features of preeclampsia but cannot be attributed to hypertension alone

1991 • 191 citations

Endothelial-derived relaxing factor released by endothelial cells of human umbilical vessels and its impairment in pregnancy-induced hypertension

1991 • 189 citations

Early detection of preeclampsia

1991 • 170 citations

Sera antioxidant activity in uncomplicated and preeclamptic pregnancies

1993 • 166 citations

Plasma endothelin levels in preeclampsia: Elevation and correlation with uric acid levels and renal impairment

1992 • 155 citations

Diagnosis of preeclampsia.

1985 • 147 citations

FACTOR-VIII CONSUMPTION IN PRE-ECLAMPSIA

1977 • 142 citations

Capillary Permeability and Extracellular Fluid Volumes in Pregnancy-Induced Hypertension

1989 • 122 citations

Sera From Preeclamptic Women Specifically Activate Human Umbilical Vein Endothelial Cells In Vitro: Morphological and Biochemical Evidence

1992 • 111 citations

Genetic control of susceptibility to eclampsia and miscarriage

1988 • 111 citations

Increased lipolytic activity and high ratio of free fatty acids to albumin in sera from women with preeclampsia leads to triglyceride accumulation in cultured endothelial cells

1992 • 107 citations

Anti-vascular endothelial cell antibodies in severe preeclampsia

1990 • 103 citations

Decidual arteriopathy in hypertension and diabetes in pregnancy: Immunofluorescent studies

1981 • 101 citations

Potential role of endothelin-1 in normal and hypertensive pregnancies

1991 • 91 citations

Sera from preeclamptic women increase the content of triglycerides and reduce the release of prostacyclin in cultured endothelial cells

1991 • 91 citations

Immunoreactive circulating endothelin-1 in normal andhypertensive pregnancies

1992 • 80 citations

Immunology of preeclampsia.

1991 • 78 citations

Immunologic Aspects of Preeclampsia

1991 • 74 citations

Antithrombin III activity in women with hypertension during pregnancy.

1985 • 72 citations

Increased plasma levels of the novel vasoconstrictor peptide endothelin in severe pre-eclampsia

1991 • 71 citations

Thrombocytopenia in Preeclampsia and Eclampsia

1982 • 71 citations

Decreased levels of polyunsaturated fatty acids in preeclampsia

1991 • 70 citations

Pathological Anatomy of Acute Hypertension of Pregnancy

1964 • 68 citations

ASSOCIATION BETWEEN SUSCEPTIBILITY TO PRE-ECLAMPSIA WITHIN FAMILIES AND HLA DR4

1989 • 65 citations

Serum arachidonic acid levels in normal and preeclamptic pregnancies

1984 • 65 citations

Prevention and Treatment of Pregnancy-Associated Hypertension: What Have We Learned in the Last 10 Years?

1991 • 62 citations

Endothelial cell activation as a pathogenetic factor in preeclampsia.

1991 • 59 citations

Prolonged blood pressure elevation after endothelin administration in bilaterally nephrectomized rats

1989 • 59 citations

An exclusion map for pre-eclampsia: assuming autosomal recessive inheritance.

1992 • 57 citations

The possible role of endothelial cells in hypertensive disorders during pregnancy.

1992 • 53 citations

Growth factor activity in the blood of women in whom preeclampsia develops is elevated from early pregnancy

1990 • 47 citations

Preeclamptic Sera Stimulate Increased Platelet‐Derived Growth Factor mRNA and Protein Expression by Cultured Human Endothelial Cells

1991 • 46 citations

The role of vascular endothelium in the pathogenesis of connective tissue disease: endothelial injury, activation, participation and response.

1990 • 46 citations

The Role of Cerebral Microvessel Endothelium in Regulation of Cerebral Blood Flow Through Production of Endothelin-1

1991 • 42 citations

Cellular immunity in preeclampsia: alterations in T-lymphocyte subpopulations during early pregnancy.

1991 • 39 citations

Pre‐eclampsia is associated with HLA‐DR4 sharing between mother and fetus

1990 • 39 citations

Role of endothelium-derived relaxing factor in regulation of vascular tone and remodeling. Update on humoral regulation of vascular tone.

1991 • 38 citations

Endomyocardial ultrastructural findings in preeclampsia

1991 • 38 citations

Magnesium sulfate therapy in preeclampsia is associated with increased urinary cyclic guanosine monophosphate excretion

1992 • 34 citations

Uterine defect in a twin pregnancy with a history of hysteroscopic fundal perforation.

1992 • 34 citations

Erythrocyte Glutathione Peroxidase Activity in Hypertensive Complications of Pregnancy

1990 • 28 citations

Mineralocorticoid effector mechanism in preeclampsia

1992 • 28 citations

Hypertensive disorders in pregnancy. The role of eicosanoids.

1991 • 24 citations

Whole-blood fibrinolytic activity in normal and hypertensive pregnancies and its relation to the placental concentration of urokinase inhibitor

1979 • 23 citations

Hemostasis in hypertensive disorders of pregnancy.

1988 • 21 citations

Renal Biopsy and Its Clinical Correlation in Toxemia of Pregnancy

1964 • 19 citations

Immunofluorescent Studies of the Endometrial Arteries in the First Trimester of Pregnancy

1985 • 18 citations

Maternal and umbilical venous levels of endothelin in women with pre-eclampsia.

1992 • 15 citations

Mineralocorticoids and mineralocorticoid receptors in mononuclear leukocytes in patients with pregnancy-induced hypertension

1992 • 13 citations

Mineralocorticoid effector mechanism in preeclampsia

1992 • 12 citations

Mineralocorticoids and mineralocorticoid receptors in mononuclear leukocytes in patients with pregnancy-induced hypertension

1992 • 9 citations

Diagnosis of the placental antecedents of pre‐eclampsia

1992 • 5 citations