Gene Correction of the Apolipoprotein (Apo) E2 Phenotype to Wild-type ApoE3 by in Situ Chimeraplasty

A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine.

1995 • 6,103 citations

Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology

1988 • 3,984 citations

Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI.

1990 • 2,936 citations

Apolipoprotein E: Structure-Function Relationships

1994 • 801 citations

Polyethylenimine but Not Cationic Lipids Promotes Transgene Delivery to the Nucleus in Mammalian Cells

1998 • 711 citations

Prevention of Atherosclerosis in Apolipoprotein E-Deficient Mice by Bone Marrow Transplantation

1995 • 467 citations

Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein.

1990 • 451 citations

Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia): questions, quandaries, and paradoxes

1999 • 424 citations

Apolipoprotein E

1999 • 373 citations

Correction of the Mutation Responsible for Sickle Cell Anemia by an RNA-DNA Oligonucleotide

1996 • 318 citations

In vivo site-directed mutagenesis of the factor IX gene by chimeric RNA/DNA oligonucleotides

1998 • 263 citations

Apolipoprotein E and atherosclerosis

2000 • 247 citations

Targeted gene correction of episomal DNA in mammalian cells mediated by a chimeric RNA.DNA oligonucleotide.

1996 • 221 citations

Apolipoprotein E Inhibits Platelet Aggregation through the L-Arginine:Nitric Oxide Pathway

1997 • 201 citations

Correction of the UDP-glucuronosyltransferase gene defect in the Gunn rat model of Crigler–Najjar syndrome type I with a chimeric oligonucleotide

1999 • 200 citations

Targeted manipulation of maize genes in vivo using chimeric RNA/DNA oligonucleotides

1999 • 198 citations

Nonviral Gene Delivery to the Rat Kidney with Polyethylenimine

1997 • 186 citations

Peripheral markers in testing pathophysiological hypotheses and diagnosing Alzheimer's disease

1998 • 167 citations

Rescue of dystrophin expression in mdx mouse muscle by RNA/DNA oligonucleotides

2000 • 161 citations

In vivo targeted repair of a point mutation in the canine dystrophin gene by a chimeric RNA/DNA oligonucleotide

2000 • 158 citations

Overcoming the Obstacles to Gene Therapy

1997 • 156 citations

Apolipoprotein E deficiency in mice: gene replacement and prevention of atherosclerosis using adenovirus vectors.

1995 • 145 citations

Overexpression of apolipoprotein E in transgenic mice: marked reduction in plasma lipoproteins except high density lipoprotein and resistance against diet-induced hypercholesterolemia.

1992 • 145 citations

Stable and inheritable changes in genotype and phenotype of albino melanocytes induced by an RNA-DNA oligonucleotide

1998 • 143 citations

Targeted nucleotide exchange in the alkaline phosphatase gene of HuH-7 cells mediated by a chimeric RNA/DNA oligonucleotide

1997 • 123 citations

Plasma apolipoprotein A-I, A-II, B, E and C-III containing particles in men with premature coronary artery disease

1991 • 123 citations

Rapid Regression of Atherosclerosis Induced by Liver-Directed Gene Transfer of ApoE in ApoE-Deficient Mice

1999 • 109 citations

Apolipoprotein E prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits.

1992 • 91 citations

THP-1 cells form foam cells in response to coculture with lipoproteins but not platelets.

1991 • 70 citations

Complete Atherosclerosis Regression After Human ApoE Gene Transfer in ApoE-Deficient/Nude Mice

2000 • 66 citations

Gene Repair Using Chimeric RNA/DNA Oligonucleotides

1999 • 65 citations

Effects of the apolipoprotein E polymorphism on uptake and transfer of cell-derived cholesterol in plasma.

1995 • 63 citations

Phenotypic Correction of Hypercholesterolemia in ApoE-Deficient Mice by Adenovirus-Mediated In Vivo Gene Transfer

1995 • 59 citations

Targeted gene correction: a new strategy for molecular medicine

1998 • 54 citations

Macrophages, lipoprotein metabolism, and atherosclerosis

1999 • 53 citations

In the Absence of Endogenous Mouse Apolipoprotein E, Apolipoprotein E*2(Arg-158 → Cys) Transgenic Mice Develop More Severe Hyperlipoproteinemia than Apolipoprotein E*3-Leiden Transgenic Mice

1996 • 51 citations

Synthesis and secretion of apolipoprotein E occur independently of synthesis and secretion of apolipoprotein B-containing lipoproteins in HepG2 cells.

1992 • 50 citations

Apolipoprotein E phenotype determined by agarose gel electrofocusing and immunoblotting.

1989 • 45 citations

Characterization of five new mutants in the carboxyl-terminal domain of human apolipoprotein E: no cosegregation with severe hyperlipidemia.

1993 • 42 citations

Peripheral markers in testing pathophysiological hypotheses and diagnosing Alzheimer's disease

1998 • 35 citations

Apolipoprotein E phenotype determined by agarose gel electrofocusing and immunoblotting.

1989 • 34 citations

Rapid isolation of highly productive recombinant Chinese hamster ovary cell lines

1994 • 31 citations

Overexpression of Apolipoprotein E Prevents Development of Diabetic Hyperlipidemia in Transgenic Mice

1995 • 20 citations

Factor(s) required by EBV transformed lymphocytes to grow under limiting dilution conditions

1991 • 5 citations