Apolipoprotein E deficiency in mice: gene replacement and prevention of atherosclerosis using adenovirus vectors.

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5

1977 • 4,801 citations

Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology

1988 • 3,984 citations

Firefly luciferase gene: structure and expression in mammalian cells.

1987 • 3,088 citations

A rapid method for determining sequences in DNA by primed synthesis with DNA polymerase

1975 • 2,622 citations

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

1987 • 2,368 citations

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

1992 • 2,216 citations

Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E

1992 • 2,189 citations

Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy.

1994 • 1,599 citations

Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery.

1993 • 1,578 citations

Quantitative assessment of atherosclerotic lesions in mice

1987 • 957 citations

Firefly Luciferase Gene: Structure and Expression in Mammalian Cells

1987 • 924 citations

Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells.

1992 • 897 citations

An Adenovirus Vector for Gene Transfer into Neurons and Glia in the Brain

1993 • 746 citations

Adenovirus-Mediated Transfer of a Recombinant α1-Antitrypsin Gene to the Lung Epithelium in Vivo

1991 • 743 citations

High-Efficiency Transformation of Mammalian Cells by Plasmid DNA

1987 • 729 citations

A simple technique for the rescue of early region I mutations into infectious human adenovirus type 5

1988 • 606 citations

Rabbit very low density lipoprotein receptor: a low density lipoprotein receptor-like protein with distinct ligand specificity.

1992 • 548 citations

Prevention of Atherosclerosis in Apolipoprotein E-Deficient Mice by Bone Marrow Transplantation

1995 • 467 citations

Adenovirus–mediated in vivo gene transfer and expression in normal rat liver

1992 • 451 citations

Development of adenovirus vectors for the expression of heterologous genes.

1988 • 386 citations

Firefly luciferase as a tool in molecular and cell biology

1988 • 373 citations

Adenovirus mediated expression of therapeutic plasma levels of human factor IX in mice

1993 • 345 citations

Evaluation of the Transfer and Expression in Mice of an Enzyme-Encoding Gene Using a Human Adenovirus Vector

1990 • 325 citations

Adenovirus-Mediated Transfer of the CFTR Gene to Lung of Nonhuman Primates: Toxicity Study

1993 • 324 citations

Assessment of Recombinant Adenoviral Vectors for Hepatic Gene Therapy

1993 • 310 citations

Adenovirus as an expression vector in muscle cells in vivo.

1992 • 301 citations

Familial apolipoprotein E deficiency.

1986 • 300 citations

Synthetic low and high fat diets for the study of atherosclerosis in the mouse.

1990 • 291 citations

Nucleotide sequence and structure of the human apolipoprotein E gene.

1985 • 289 citations

Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice.

1990 • 281 citations

Type III Hyperlipoproteinemia Associated with Apolipoprotein E Deficiency

1981 • 272 citations

Adenovirus vector-mediated in vivo gene transfer into adult murine retina.

1994 • 239 citations

Type III Hyperlipoproteinemia: Diagnosis, Molecular Defects, Pathology, and Treatment

1983 • 232 citations

Low density lipoprotein receptor internalizes low density and very low density lipoproteins that are bound to heparan sulfate proteoglycans via lipoprotein lipase

1993 • 218 citations

The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds lipoprotein lipase and beta-migrating very low density lipoprotein associated with the lipase

1993 • 200 citations

Adenovirus-Mediated Transfer of the CFTR Gene to Lung of Nonhuman Primates: Biological Efficacy Study

1993 • 196 citations

Adenoviral-mediated gene transfer to rabbit synovium in vivo.

1993 • 186 citations

Adenovirus-mediated transfer of a recombinant human alpha 1-antitrypsin cDNA to human endothelial cells.

1992 • 180 citations

Monitoring foreign gene expression by a human adenovirus-based vector using the firefly luciferase gene as a reporter

1993 • 141 citations

Genetic heterogeneity of lipoproteins in inbred strains of mice: Analysis by gel-permeation chromatography

1990 • 138 citations

Transgenic mouse models of lipoprotein metabolism and atherosclerosis.

1993 • 129 citations

Structure, function and role of lipoprotein lipase in lipoprotein metabolism

1994 • 124 citations

Characterization of a unique human apolipoprotein E variant associated with type III hyperlipoproteinemia.

1980 • 123 citations

Identification and DNA sequence of a human apolipoprotein E cDNA clone.

1982 • 101 citations

Adenovirus-mediated transfer of a gene encoding human apolipoprotein A-I into normal mice increases circulating high-density lipoprotein cholesterol.

1994 • 86 citations

Cloning and regulation of messenger RNA for mouse apolipoprotein E.

1984 • 84 citations

Role of Heparan Sulfate Proteoglycans and the LDL Receptor‐Related Protein in Remnant Lipoprotein Metabolisma

1994 • 68 citations

A young type III hyperlipoproteinemic patient associated with apolipoprotein E deficiency

1989 • 65 citations

Phenotypic Correction of Hypercholesterolemia in ApoE-Deficient Mice by Adenovirus-Mediated In Vivo Gene Transfer

1995 • 59 citations

Familial apolipoprotein E deficiency and type III hyperlipoproteinemia due to a premature stop codon in the apolipoprotein E gene.

1992 • 58 citations

Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells.

1992 • 54 citations

Apolipoprotein E deficiency with a depressed mRNA of normal size

1991 • 36 citations

Erythropoietin Gene Transfer and Expression in Adult Normal Mice: Use of an Adenovirus Vector

1994 • 35 citations

Lipoprotein separation and analysis for clinical studies

1992 • 23 citations

Cellular and Molecular Biology of Lipoprotein Metabolism: Characterization of Lipoprotein Receptor-Ligand Interactions

1986 • 23 citations

Disorders of Lipoprotein Metabolism

2014 • 18 citations