Reduced growth-factor requirement of keloid-derived fibroblasts may account for tumor growth.

Physiological Functions of Glucocorticoids in Stress and Their Relation to Pharmacological Actions*

1984 • 3,073 citations

Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.

1986 • 2,878 citations

Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.

1986 • 2,499 citations

The biology of platelet-derived growth factor

1986 • 2,036 citations

Autocrine growth factors and cancer

1985 • 1,462 citations

Transforming Growth Factor-β: Biological Function and Chemical Structure

1986 • 1,198 citations

Type beta transforming growth factor: a bifunctional regulator of cellular growth.

1985 • 1,107 citations

cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines

1986 • 786 citations

Induction of c-sis mRNA and activity similar to platelet-derived growth factor by transforming growth factor beta: a proposed model for indirect mitogenesis involving autocrine activity.

1986 • 541 citations

Transforming growth factor-beta increases steady state levels of type I procollagen and fibronectin messenger RNAs posttranscriptionally in cultured human dermal fibroblasts.

1987 • 467 citations

Polypeptide Transforming Growth Factors Isolated from Bovine Sources and Used for Wound Healing in Vivo

1983 • 451 citations

Insulin-like growth factor-II gene expression in Wilms' tumour and embryonic tissues

1985 • 413 citations

The effect of transforming growth factor-beta on cell proliferation and collagen formation by lung fibroblasts.

1987 • 399 citations

Expression of insulin-like growth factor-II transcripts in Wilms' tumour

1985 • 352 citations

Normal embryo fibroblasts release transforming growth factors in a latent form

1984 • 336 citations

Coexpression of a PDGF-like growth factor and PDGF receptors in a human osteosarcoma cell line: Implications for autocrine receptor activation

1984 • 238 citations

Keloids: A review

1981 • 237 citations

Platelet-derived growth factor

1985 • 226 citations

Growth kinetics and collagen synthesis of normal skin, normal scar and keloid fibroblasts in vitro

1979 • 203 citations

Type beta transforming growth factor/growth inhibitor stimulates entry of monolayer cultures of AKR-2B cells into S phase after a prolonged prereplicative interval.

1985 • 191 citations

Insulin-like growth factor II in human adrenal pheochromocytomas and Wilms tumors: expression at the mRNA and protein level.

1987 • 191 citations

Regulation of production of a platelet‐derived growth factor‐like protein by cultured bovine aortic endothelial cells

1984 • 158 citations

Dexamethasone modulates binding and action of epidermal growth factor in serum-free cell culture

1978 • 156 citations

Transforming viruses directly reduce the cellular growth requirement for a platelet derived growth factor

1978 • 134 citations

Stimulation of Division of Sparse and Confluent 3T3 Cell Populations by a Fibroblast Growth Factor, Dexamethasone, and Insulin

1974 • 121 citations

Bi‐functional action of transforming growth factor‐β on DNA synthesis in early passage human fetal fibroblasts

1986 • 121 citations

Differential effects of hydrocortisone on both growth and collagen metabolism of human fibroblasts from normal and keloid tissue

1978 • 99 citations

Growth factor‐induced proliferation of human fibroblasts in serum‐free culture depends on cell density and extracellular calcium concentration

1984 • 95 citations

CELL SIZE AND GROWTH CHARACTERISTICS OF CULTURED FIBROBLASTS ISOLATED FROM NORMAL AND KELOID TISSUE

1976 • 78 citations

Insulin‐like growth factor I/somatomedin‐C (IGF‐I/SM‐C) and glucocorticoids synergistically regulate mitosis in competent human fibroblasts

1983 • 70 citations

Age dependent production of a competence factor by human fibroblasts

1983 • 51 citations

Hormonal control of the replication of human fetal fibroblasts: Role of somatomedin C/insulin‐like growth factor I

1986 • 42 citations

Differences in growth response to hydrocortisone and ascorbic acid by human diploid fibroblasts

1977 • 42 citations

Autocrine regulation of growth: I. Glucocorticoid inhibition is overcome by exogenous platelet derived growth factor

1984 • 37 citations

Comparative effects of human platelet growth factor on the growth and morphology of human fetal and adult diploid fibroblasts

1977 • 35 citations

Synthesis and secretion of an epidermal growth factor (EGF) by human fibroblast cells in culture

1985 • 35 citations

Alteration of amino acid transport by hydrocortisone. Different effects in human fibroblasts derived from normal skin and keloid.

1982 • 29 citations

A biological assay for epidermal growth factor/urogastrone and related polypeptides

1986 • 24 citations

Variation in Prolyl Hydroxylase Activity of Keloid-Derived and Normal Human Fibroblasts in Response to Hydrocortisone and Ascorbic Acid

1983 • 24 citations

Newborn human skin fibroblasts senesce in vitro without acquiring adult growth factor requirements*1

1984 • 22 citations

Fibroblast heterogeneity in glucocorticoid regulation of collagen metabolism: Genetic or epigenetic?

1982 • 21 citations

Clinical and Biochemical Features of Normal, Defective, and Pathologic Scars

1977 • 20 citations

Developmental biology: Autocrine control of growth?

1984 • 14 citations