Regulation of Peripheral Nerve Regeneration by Insulin‐like Growth Factors^a

Degeneration and Regeneration of the Nervous System.

1929 • 2,924 citations

Nerve growth factor.

1968 • 2,025 citations

The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin.

1978 • 1,530 citations

Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection.

1987 • 1,012 citations

Proliferation, differentiation and degeneration in the spinal ganglia of the chick embryo under normal and experimental conditions

1949 • 974 citations

Somatomedin: Proposed Designation for Sulphation Factor

1972 • 840 citations

Primary structure of human insulin‐like growth factor II

1978 • 776 citations

Polyneuronal innervation of skeletal muscle in new‐born rats and its elimination during maturation.

1976 • 774 citations

Neuromuscular transmission in new‐born rats

1970 • 701 citations

Timing and site of nerve growth factor synthesis in developing skin in relation to innervation and expression of the receptor

1987 • 555 citations

Somatomedin-C/insulin-like growth factor-I and insulin-like growth factor-II mRNAs in rat fetal and adult tissues.

1986 • 531 citations

Differential expression of insulin-like growth factor genes in rat central nervous system.

1988 • 477 citations

Nerve sprouting in innervated adult skeletal muscle induced by exposure to elevated levels of insulin-like growth factors.

1990 • 441 citations

Effects of insulin, insulin-like growth factor-II, and nerve growth factor on neurite formation and survival in cultured sympathetic and sensory neurons

1986 • 426 citations

Reduction of the naturally occurring motor neuron loss by enlargement of the periphery

1976 • 425 citations

Tissue Distribution of Insulin-Like Growth Factor I and II Messenger Ribonucleic Acid in the Adult Rat*

1987 • 418 citations

Insulin-like growth factor-II gene expression in Wilms' tumour and embryonic tissues

1985 • 413 citations

A study of foetal and new‐born rat muscle fibres

1962 • 408 citations

ANTIBODY-SUPPRESSIBLE AND NONSUPPRESSIBLE INSULIN-LIKE ACTIVITIES IN HUMAN SERUM AND THEIR PHYSIOLOGIC SIGNIFICANCE. AN INSULIN ASSAY WITH ADIPOSE TISSUE OF INCREASED PRECISION AND SPECIFICITY*

1963 • 399 citations

FIBRIN SUTURE OF PERIPHERAL NERVES

1940 • 374 citations

Observations on the elimination of polyneuronal innervation in developing mammalian skeletal muscle.

1978 • 363 citations

Regression versus peripheral control of differentiation in motor hypoplasia

1958 • 350 citations

Development of neuromuscular junctions in rat embryos

1981 • 310 citations

THE FINE STRUCTURE OF MOTOR ENDPLATE MORPHOGENESIS

1969 • 305 citations

Insulin-like growth factor I (IGF-I) stimulates regeneration of the rat sciatic nerve

1989 • 280 citations

Mosaic evolution of the insulin-like growth factors. Organization, sequence, and expression of the rat insulin-like growth factor I gene.

1987 • 279 citations

THE EFFECTS OF BOTULINUM TOXIN ON THE PATTERN OF INNERVATION OF SKELETAL MUSCLE IN THE MOUSE

1968 • 276 citations

Evidence that endogenous beta nerve growth factor is responsible for the collateral sprouting, but not the regeneration, of nociceptive axons in adult rats.

1987 • 265 citations

Brain neurons develop in a serum and glial free environment: effects of transferrin, insulin- insulin-like growth factor-I and thyroid hormone on neuronal survival, growth and differentiation

1987 • 249 citations

The effect of prolonged, reversible block of nerve impulses on the elimination of polyneuronal innervation of new-born rat skeletal muscle fibers

1979 • 230 citations

Evidence indicating trophic importance of IGF‐1 in regenerating peripheral nerves

1986 • 223 citations

Neuronotrophic activities accumulate in vivo within silicone nerve regeneration chambers

1983 • 218 citations

Effects of insulin, insulin-like growth factor-II and nerve growth factor on neurite outgrowth in cultured human neuroblastoma cells

1984 • 194 citations

"Myopathic" Changes in Chronically Denervated Muscle

1967 • 193 citations

Rat insulin-like growth factor II gene

1986 • 192 citations

New Neurotrophic Factors

1983 • 190 citations

Denervation increases a neurite-promoting activity in extracts of skeletal muscle

1983 • 189 citations

Localization of binding sites for insulin-like growth factor-I (IGF-I) in the rat brain by quantitative autoradiography

1988 • 179 citations

Purification and Characterization of Multiplication‐Stimulating Activity

1980 • 171 citations

The spatial and temporal pattern of beta NGF receptor expression in the developing chick embryo.

1985 • 163 citations

Competition for survival among developing ciliary ganglion cells

1980 • 163 citations

NGF receptor-mediated reduction in axonal NGF uptake and retrograde transport following sciatic nerve injury and during regeneration

1991 • 161 citations

Developmental and tissue-specific expression of a family of transcripts related to rat insulin-like growth factor II mRNA

1985 • 155 citations

Retrograde transport of nerve growth factor (NGF) in motoneurons of developing rats: Assessment of potential neurotrophic effects

1988 • 151 citations

Competence of nerve tissue as distal insert promoting nerve regeneration in a silicone chamber

1984 • 145 citations

Relationship of insulin-like growth factor II gene expression in muscle to synaptogenesis.

1989 • 143 citations

Insulin-like growth factor II stimulates motor nerve regeneration.

1992 • 141 citations

Experiments on Motor Nerve Regeneration and the Direct Neurotization of Paralyzed Muscles by Their Own and by Foreign Nerves

1917 • 134 citations

Motor and Sensory Hyperplasia following Limb-Bud Transplantations in Chick Embryos

1939 • 123 citations

Structure and expression of the rat insulin-like growth factor II (rIGF-II) gene. rIGF-II RNAs are transcribed from two promoters.

1986 • 122 citations

Identification of embryonic motoneurons in vitro: their survival is dependent on skeletal muscle

1980 • 121 citations

Effects of nerve growth factor on the survival and synaptic function of Ia sensory neurons axotomized in neonatal rats

1986 • 120 citations

Morphological Changes in the Denervated Muscle

1962 • 119 citations

Cell death of motoneurons in the chick embryo spinal cord. V. Evidence on the role of cell death and neuromuscular function in the formation of specific peripheral connections

1981 • 117 citations

Rapid axoplasmic transport of insulin-like growth factor I in the sciatic nerve of adult rats

1987 • 113 citations

Insulin-like growth factor II increases the rate of sciatic nerve regeneration in rats

1993 • 111 citations

Spinal cord neuronotrophic factors (SCNTFs): I. Bioassay of Schwannoma and other conditioned media

1982 • 108 citations

A study of postnatal growth of skeletal muscle in the rat

1965 • 106 citations

Insulin and somatemedin MSA promote nerve growth factor‐independent neurite formation by cultured chick dorsal root ganglionic sensory neurons

1982 • 89 citations

Neuronal growth factors produced by adult peripheral nerve after injury

1986 • 89 citations

Axon guidance during reinnervation of skeletal muscle

1985 • 81 citations

Insulin and related growth factors: effects on the nervous system and mechanism for neurite growth and regeneration

1988 • 70 citations

ATROPHY AND DEGENERATION IN THE MUSCLE SPINDLE.

1932 • 64 citations

Nerve regeneration chamber: evaluation of exogenous agents applied by multiple injections

1987 • 63 citations

An in vivo assay of neurotropic activity

1983 • 62 citations

Trophic effects of skeletal muscle extracts on ventral spinal cord neurons in vitro: separation of a protein with morphologic activity from proteins with cholinergic activity.

1985 • 59 citations

Influence of non-neuronal cells on regeneration of the rat sciatic nerve

1988 • 57 citations

The insulin-like growth factor-II (IGF-II) receptor of rat brain: regional distribution visualized by autoradiography

1988 • 56 citations

Source of the stimulus for nerve terminal sprouting in partially denervated muscle

1982 • 55 citations

Nerve Growth Factor: Actions in the Peripheral and Central Nervous Systems

1993 • 53 citations

A STUDY OF THE FACTORS INFLUENCING INNERVATION OF MUSCLES BY IMPLANTED NERVES

1951 • 53 citations

Neurite Formation Modulated by Nerve Growth Factor, Insulin, and Tumor Promoter Receptors

1985 • 43 citations

Selective reinnervation of transplanted muscles by their original motoneurons in the axolotl

1987 • 38 citations

Neurobiology of Insulin and Insulin-Like Growth Factors

1993 • 36 citations

Chapter 2 Nerve Fiber Growth and the Cellular Response to Axotomy

1982 • 35 citations

Reinnervation and recovery of cat muscle receptors after long-term denervation

1986 • 35 citations

The response of cultured trigeminal and spinal cord motoneurons to nerve growth factor

1990 • 34 citations

Role of Insulin, Insulinlike Growth Factors, and Nerve Growth Factor in Neurite Formation

1987 • 26 citations

Molecular Mechanisms of Neurite Formation Stimulated by Insulin-like Factors and Nerve Growth Factor

1987 • 16 citations

Second Messengers Mediating Gene Expression Essential to Neurite Formation Directed by Insulin and Insulin-Like Growth Factors

1991 • 16 citations

Disuse Atrophy of Muscle

1970 • 15 citations

Brain Aging: Molecular Biology, the Aging Process and Neurodegenerative Disease

1990 • 6 citations

Insulin-like growth factor II gene expression: relationship to the development and regeneration of neuromuscular synapses

1990 • 3 citations