Production of the penicillin precursor δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine (ACV) by cell-free extracts fromStreptomyces clavuligerus

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Analysis of biological thiols: Derivatization with monobromobimane and separation by reverse-phase high-performance liquid chromatography

1981 • 451 citations

Isopenicillin N synthetase of Penicillium chrysogenum, an enzyme that converts delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine to isopenicillin N

1985 • 134 citations

Purification of isopenicillin N synthetase

1984 • 129 citations

δ -(L-α-Aminoadipyl)-L-cysteinyl-D-valine synthetase (ACV synthetase): a multifunctional enzyme with broad substrate specificity for the synthesis of penicillin and cephalosporin precursors

1987 • 114 citations

Deacetoxycephalosporin C synthetase and deacetoxycephalosporin C hydroxylase are two separate enzymes in Streptomyces clavuligerus.

1985 • 94 citations

A Pure Enzyme Catalyzing Penicillin Biosynthesis

1984 • 92 citations

Cell-free synthesis of δ-(L-α-aminoadipyl)-L-cysteine, the first intermediate of penicillin and cephalosporin biosynthesis

1986 • 68 citations

Purification of isopenicillin N synthetase from Streptomyces clavuligerus

1986 • 57 citations

Biosynthesis of peptides containing α-aminoadipic acid and cysteine in extracts of a Cephalosporium sp

1971 • 45 citations

Total synthesis of δ-(<scp>L</scp>-α-aminoadipyl)-<scp>L</scp>-cysteinyl-<scp>D</scp>-valine (ACV), a biosynthetic precursor of penicillins and cephalosporins

1979 • 36 citations

Gel centrifugation chromatography for macromolecular separations

1982 • 23 citations

A study of the biosynthesis of the tripeptide δ-(<scp>l</scp>-α-aminoadipyl)-<scp>l</scp>-cysteinyl-<scp>d</scp>-valine in a β-lactam-negative mutant of Cephalosporium acremonium

1983 • 23 citations

[29] δ-(α-Aminoadipyl)cysteinylvaline synthetase

1975 • 20 citations