Meperidine: A Critical Review

Central nervous system excitatory effects of meperidine in cancer patients

1983 • 409 citations

DRUG TREATMENT IN PSYCHIATRY

1964 • 372 citations

Accumulation of Normeperidine, an Active Metabolite of Meperidine, in Patients with Renal Failure or Cancer

1977 • 354 citations

Ceiling effect for respiratory depression by nalbuphine

1980 • 248 citations

Propofol versus midazolam and meperidine for conscious sedation in GI endoscopy

2000 • 229 citations

Multiple intramuscular injections: A major source of variability in analgesic response to meperidine

1980 • 220 citations

Relationship Between Blood Meperidine Concentrations and Analgesic Response

1980 • 207 citations

SEROTONIN SYNDROME

1997 • 202 citations

Meperidine kinetics in man; Intravenous injection in surgical patients and volunteers

1975 • 201 citations

The Serotonin Syndrome

1995 • 197 citations

Long-Acting Opioids for Chronic Pain: Pharmacotherapeutic Opportunities to Enhance Compliance, Quality of Life, and Analgesia

2001 • 188 citations

Clinical Pharmacokinetics Pethidine

1978 • 174 citations

The effect of cirrhosis on the disposition and elimination of meperidine in man

1974 • 163 citations

Patient‐Controlled Analgesic Therapy: Clinical Experience

1982 • 134 citations

Dolantin, ein neuartiges Spasmolytikum und Analgetikum

1939 • 133 citations

The "specialty" of general practitioner obstetrics.

1982 • 130 citations

Meperidine-induced delirium

1987 • 119 citations

Meperidine: Therapeutic use and toxicity

1995 • 109 citations

Normeperidine Toxicity

1986 • 105 citations

The interaction between monoamine oxidase inhibitors and narcotic analgesics in mice

1969 • 97 citations

The physiological disposition and fate of meperidine (demerol) in man and a method for its estimation in plasma.

1955 • 96 citations

Clinical characteristics of addictions

1953 • 96 citations

A comparison of morphine, pethidine and fentanyl in the postsurgical patient-controlled analgesia environment

1996 • 93 citations

A cross-over comparison of the effect of morphine, pethidine, pentazocine, and phenazocine on biliary pressure

1971 • 90 citations

Dangerous Potentiation of Pethidine by Iproniazid, and its Treatment

1960 • 90 citations

Meperidine-Related Seizures Associated with Patient-Controlled Analgesia Pumps

1993 • 88 citations

Self‐administered nalbuphine, morphine and pethidine

1985 • 87 citations

Dose requirements, efficacy and side effects of morphine and pethidine delivered by patient-controlled analgesia after gynaecological surgery

1996 • 85 citations

Neurologic events after partial exchange transfusion for priapism in sickle cell disease

1992 • 84 citations

THE CLINICAL EVALUATION OF MORPHINE AND ITS SUBSTITUTES AS ANALGESICS.

1964 • 84 citations

The effect of ageing on plasma pethidine concentration.

1975 • 80 citations

A Comparison of Morphine, Meperidine, and Oxymorphone as Utilized in Patient-controlled Analgesia Following Cesarean Delivery

1989 • 79 citations

FATAL TOXIC ENCEPHALITIS OCCURRING DURING IPRONIAZID THERAPY IN PULMONARY TUBERCULOSIS

1955 • 78 citations

Comparison of Psychological Effects of Certain Centrally Acting Drugs in Man

1957 • 76 citations

Clinical Effects of Meperidine in Hospitalized Medical Patients

1978 • 76 citations

Monoamine Oxidase Inhibitors and Narcotic Analgesics

1987 • 76 citations

Meperidine and Lidocaine Block of Recombinant Voltage-Dependent Na+Channels

1999 • 74 citations

Potentiation of Pethidine

1960 • 74 citations

The Clinical Pharmacology of Meperidine—Comparison of Routes of Administration

1976 • 74 citations

Opioid drugs cause bile duct obstruction during hepatobiliary scans

1984 • 73 citations

Neurotoxicity of meperidine

1985 • 73 citations

Survey of Pain Management Therapy Provided for Children With Sickle Cell Disease

1992 • 72 citations

Effects of Low Doses of Meperidine on Neonatal Behavior

1985 • 70 citations

The Effect of Equi-Analgesic Doses of Fentanyl, Morphine, Meperidine and Pentazocine on Common Bile Duct Pressure

1980 • 70 citations

CORRESPONDENCE: To the Editor

1955 • 69 citations

NORPETHIDINE TOXICITY AND PATIENT CONTROLLED ANALGESIA

1993 • 68 citations

Patient-controlled analgesia for sickle-cell-related pain

1993 • 67 citations

Differing effects of pethidine and morphine on human sphincter of Oddi motility

1990 • 65 citations

ALARMING REACTION TO PETHIDINE IN PATIENTS ON PHENELZINE

1962 • 65 citations

Subjective, psychomotor, and physiological effects of cumulative doses of opioid mu agonists in healthy volunteers.

1999 • 65 citations

Effects of meperidine on the pancreatic and biliary sphincter

1996 • 63 citations

Clinical and Experimental Aspects of Injection Injuries of Peripheral Nerves

1980 • 62 citations

Disposition of meperidine and normeperidine following multiple doses during labor

1985 • 61 citations

Effects of Renal Insufficiency on the Pharmacokinetics and Pharmacodynamics of Opioid Analgesics

1987 • 60 citations

Common Bile Duct Pressure Changes After Fentanyl, Morphine, Meperidine, Butorphanol, and Naloxone

1984 • 60 citations

Toxic Effects of Iproniazid in a Patient with Angina

1958 • 59 citations

Intramuscular opioids for maternal pain relief in labour: a randomised controlled trial comparing pethidine with diamorphine

1999 • 58 citations

Common Bile Duct Pressure Changes after Fentanyl, Morphine, Meperidine, Butorphanol, and Naloxone

1984 • 57 citations

Pediatric Uses of Opioids

1989 • 56 citations

Effect of phenytoin on meperidine clearance and normeperidine formation

1981 • 54 citations

Meperidine–Induced Generalized Seizures With Normal Renal Function

1997 • 51 citations

ANALGESIC EFFECTS IN HUMAN SUBJECTS OF MORPHINE, MEPERIDINE AND METHADON

1948 • 50 citations

Presystemic metabolism of meperidine to normeperidine in normal and cirrhotic subjects

1981 • 49 citations

POTENTIATION OF AMPHETAMINE AND PETHIDINE BY MONOAMINEOXIDASE INHIBITORS

1963 • 49 citations

Dangers of Monoamine Oxidase Inhibitors

1962 • 49 citations

CLINICAL EFFECTIVENESS AND SAFETY OF A NEW SYNTHETIC ANALGESIC DRUG, DEMEROL

1943 • 47 citations

Successful treatment of normeperidine neurotoxicity by hemodialysis

2000 • 46 citations

A COMPARISON OF BUPRENORPHINE AND PETHIDINE FOR IMMEDIATE POSTOPERATIVE PAIN RELIEF BY THE I.V. ROUTE

1978 • 45 citations

Anaphylaxis to Meperidine

1982 • 44 citations

Central Nervous System Toxicity Associated With Meperidine Use in Hepatic Disease

1994 • 44 citations

Systemic availability of orally administered meperidine

1976 • 44 citations

Biotransformation products of meperidine excreted in the urine of man.

1956 • 42 citations

Toxicity of norpethidine in sickle cell crisis.

1992 • 42 citations

Pediatric patient-controlled analgesia with morphine versus meperidine

1992 • 42 citations

STUDIES OF THE ADDICTION LIABILITY OF "DEMEROL" (D-140)

1942 • 42 citations

Morphine Patient-Controlled Analgesia Is Superior to Meperidine Patient-Controlled Analgesia for Postoperative Pain

1997 • 42 citations

Meperidine disposition in man: Influence of urinary pH and route of administration

1981 • 41 citations

ADDICTION TO MEPERIDINE (DEMEROL) HYDROCHLORIDE

1955 • 41 citations

Pethidine‐associated seizure in a healthy adolescent receiving pethidine for postoperative pain control

1998 • 40 citations

Effect of Analgesic Drugs on the Electromyographic Activity of the Gastrointestinal Tract and Sphincter of Oddi and on Biliary Pressure

1986 • 39 citations

Antinociceptive activity and toxicity of meperidine and normeperidine in mice.

1982 • 37 citations

The spectrum of epilepsy in sickle cell anemia

1994 • 36 citations

Anaphylaxis to Meperidine

1982 • 36 citations

A comparative study of pentazocine and meperidine on the biliary passage pressure.

1972 • 36 citations

Pethidine and Phenelzine

1962 • 35 citations

DEMEROL—A NEW SYNTHETIC ANALGESIC

1943 • 35 citations

Respiratory depression associated with meperidine spinal anaesthesia

1994 • 34 citations

Meperidine disposition in mother, neonate, and nonpregnant females

1980 • 34 citations

Morphine Patient-Controlled Analgesia Is Superior to Meperidine Patient-Controlled Analgesia for Postoperative Pain

1997 • 34 citations

MATERNAL HYPOXAEMIA AFTER PETHIDINE

1974 • 33 citations

Disposition of meperidine and normeperidine following multiple doses during labor

1985 • 33 citations

Studies on the excitatory and inhibitory influence of intracerebroventricularly injected opioids on seizure thresholds in rats*1

1984 • 32 citations

CORTICAL EFFECTS OF DEMEROL

1942 • 31 citations

Action of various new analgesic drugs on the human common bile duct.

1967 • 31 citations

Role of brain monoamines in the interaction between pethidine and tranylcypromine

1971 • 30 citations

Diffuse Myopathy Related to Meperidine Addiction in a Mother and Daughter

1968 • 30 citations

Pharmacokinetics and analgesic effect of pethidine (meperidine) and its metabolites in the rat.

1979 • 29 citations

Serum concentrations of meperidine in patients with sickle cell crisis

1986 • 27 citations

Narcotic-induced choledochoduodenal sphincter spasm reversed by glucagon.

1980 • 26 citations

Meperidine-induced seizure in a patient without renal dysfunction or sickle cell anemia.

1986 • 26 citations

Comparison of Hydromorphone and Meperidine for Ureteral Colic

1994 • 25 citations

Muscle fibrosis and contractures in a pethidine addict.

1971 • 25 citations

Factors influencing the excretion and relative physiological availability of pethidine in man

1975 • 25 citations

FURTHER STUDIES OF THE ADDICTION LIABILITY OF DEMEROL

1943 • 24 citations

Norpethidine accumulation and generalized seizure during pethidine patient-controlled analgesia.

1999 • 24 citations

Lethal Effects of Normeperidine

1992 • 23 citations

THE UTILITY OP DEMEROL AS A SUBSTITUTE FOR THE OPIATES IX PREAXESTHETIC MEDICATIOX

1943 • 23 citations

Hazards of High-Dose Meperidine

1986 • 22 citations

COMPARATIVE STUDIES WITH NARCOTICS AND NARCOTIC ANTAGONISTS IN MAN

1965 • 21 citations

Patient-Controlled Analgesia in Patients with Sickle Cell Vaso-Occlusive Crisis

1990 • 21 citations

A comparative study of four premedications *

1963 • 21 citations

STUDIES OF DRUGS GIVEN BEFORE ANAESTHESIA VII: PETHIDINE-PHENOTHIAZINE COMBINATIONS

1965 • 21 citations

Meperidine-associated seizures in a child.

1990 • 21 citations

Meperidine as a Potential Cause of Serotonin Syndrome in the Emergency Department

1999 • 19 citations

Acute neurotoxicity of meperidine in an infant

1996 • 19 citations

REACTIONS TO OTHER DRUGS IN PATIENTS TAKING MONOAMINE-OXIDASE INHIBITORS

1962 • 19 citations

THE PHARMACOLOGY AND TOXICOLOGY OF THE ETHYL ESTER OF 1-METHYL-4-PHENYL-PIPERIDINE-4-CARBOXYLIC ACID (DEMEROL)

1941 • 18 citations

Pharmacokinetics of Low‐Dose Intravenous Pethidine in Patients with Renal Dysfunction

1987 • 17 citations

Low Frequency of Meperidine-Associated Seizures in Sickle Cell Disease

1999 • 17 citations

Pethidine N-oxide: a metabolite in human urine

1972 • 16 citations

Clinical pharmacology of potent analgesics

1962 • 16 citations

Postinjection vastus lateralis atrophy: 2 case reports

2000 • 16 citations

Boxing-Related Ocular Injuries in the United States Army, 1980 to 1985

1989 • 15 citations

Pethidine and Liver Damage

1952 • 15 citations

Drug addiction among Quebec physicians.

1982 • 15 citations

PHARMACOLOGY OF DEMEROL AND ITS ANALOGUES

1948 • 15 citations

DEMEROL: A NEW SYNTHETIC ANALGETIC, SPASMOLYTIC, AND SEDATIVE AGENT. II. CLINICAL OBSERVATIONS

1944 • 14 citations

Site-Specific Pharmacokinetics and Pharmacodynamics of Intramuscular Meperidine in Elderly Postoperative Patients

1997 • 14 citations

Intramuscular pethidine (meperidine) during labor associated with metabolic acidosis in the newborn

1986 • 13 citations

DEMEROL: A NEW SYNTHETIC ANALGETIC, SPASMOLYTIC AND SEDATIVE AGENT. I. PHARMACOLOGIC STUDIES

1944 • 13 citations

Psychiatric presentation of meperidine toxicity.

1987 • 13 citations

Clinical assessment of analgesic drugs (2)

1962 • 13 citations

Hypersensitivity to Meperidine

1978 • 13 citations

An analysis of normeperidine's contribution to the rate-decreasing effects of meperidine

1978 • 12 citations

The Bioavailability of Meperidine Using Urine Assays for Meperidine and Normeperidine

1975 • 12 citations

Neonatal effects of the administration of meperidine and promethazine to the mother in labor. Double blind study

1982 • 12 citations

PETHIDINE ADDICTION

1947 • 11 citations

Effect of p-chlorophenylalanine on the interaction between pbenelzine and pethidine in conscious rabbits

1973 • 10 citations

Clinical pharmacology of the narcotic analgesics

1962 • 10 citations

Postoperative Pain Management in Children

1989 • 10 citations

DEMEROL

1943 • 10 citations

The Influence of Demerol on the Contractions of the Ureter

1943 • 10 citations

ADDICTION TO MEPERIDINE HYDROCHLORIDE (DEMEROL HYDROCHLORIDE)

1946 • 10 citations

Toxicology and addiction liability of meperidine (demerol) in experimental animals.

1951 • 9 citations

Normeperidine-Induced Seizures in Hereditary Coproporphyria

1990 • 9 citations

Drugs With Anticholinergic Side Effects

1989 • 9 citations

Attenuation of normeperidine's suppressing effect on schedule-controlled behavior

1982 • 9 citations

Opiate, opioids, and centrally acting analgesics and drug interactions: The emerging role of the psychiatrist

1998 • 9 citations

A Case of Pethidine Sensitivity

1951 • 8 citations

Analgesics as Supplements during Anæsthesia

1951 • 8 citations

Double-Blind Study Of METHOTRIMEPRAZINE, MORPHlNE, AND MEPERlDlNE for Preanesthetic Medication

1965 • 8 citations

"Perfect Sight without Glasses"

1941 • 7 citations

HABITUATION TO MEPERIDINE HYDROCHLORIDE (DEMEROL HYDROCHLORIDE)

1947 • 7 citations

The Effect of Meperidine on the Guinea Pig Extrahepatic Biliary Tract

1987 • 6 citations

High dose pharmacokinetics of meperidine in surgical patients

1978 • 6 citations

Pain Consult: Problems with Meperidine

1984 • 5 citations

Possible Sensitivity to Meperidine in Phenylketonuria

1973 • 5 citations

Possible roles of normeperidine and hyponatremia in a postoperative death.

1987 • 5 citations

VENTILATORY ARREST AFTER MEPERIDINE

1978 • 4 citations

The Actions of Demerol and Morphine on Gastrointestinal Musculature.*

1944 • 4 citations

Parenteral use of meperidine-promethazine as preanesthetic medication in ambulatory patients.

1962 • 4 citations

Clinical Appraisal of Demerol, Benadryl and Pyribenzamine

1946 • 4 citations

DEMEROL

1946 • 4 citations

Minimizing meperidine use.

1996 • 4 citations

Demerol hydrochloride

1943 • 3 citations

Unusual causes of convulsions in a hyperbaric chamber.

1998 • 3 citations

MEPERIDINE HYDROCHLORIDE USED INTRAVENOUSLY BEFORE GASTROSCOPY

1953 • 3 citations

INTRAVENOUS PETHIDINE FOR CESOPHAGOSCOPY AND GASTROSCOPY

1953 • 3 citations

Interaction of diazepam with meperidine or normeperidine on analgesia and lethality

1982 • 3 citations

Zum 100. Geburtstage Eduard Pflügers

1929 • 3 citations

THE IMPORTANCE OF ADDICTION TO THE NEWER SYNTHETIC ANALGESICS IN HUMAN THERAPY

1948 • 3 citations

Demerol premedication in the ambulatory patient

1950 • 3 citations

THE POSITION OF PETHIDINE IN ANÆSTHESIA

1951 • 3 citations

Addiction to Meperidine Hydrochloride (Demerol Hydrochloride)

1947 • 3 citations

PREANESTHETIC MEDICATION WITH INTRAMUSCULAR ADMINISTRATION OF HYDROXYZINE HYDROCHLORIDE

1963 • 3 citations

Comparison of demerol, nembutal, or benadryl with atropine or scopolamine for preoperative medication.

1959 • 3 citations

Attenuation of the behavioral effects of meperidine and normeperidine by daily administration of diazepam

1983 • 3 citations

Clinical and electroencephalographic studies of demerol addiction.

1954 • 2 citations

Demerol,* a New Departure in Analgesia

1943 • 2 citations

The effect of demerol upon the sphincter of Oddi in man.

1948 • 2 citations

PAIN CONSULT: PROBLEMS WITH MEPERIDINE

1984 • 2 citations

DEMEROL

1946 • 1 citations

Emergency medicine. Is this a drug reaction?

1998 • 1 citations

Failure to follow orders: patient arrests--coma results. Case in point: Sullivan v. Sumrall By Ritchley 618 So. 2d 1274--MS (1993).

1993 • 1 citations

Detecting the dangers of meperidine.

1995 • 1 citations

ADDICTION TO DRUGS BY MEDICAL AND PARAMEDICAL PERSONNEL.

1965 • 1 citations