The novel immunosuppressant FTY720 induces peripheral lymphodepletion of both T- and B-cells in cynomolgus monkeys when given alone, with Cyclosporine Neoral® or with RAD

FTY720, a Novel Immunosuppressant, Induces Sequestration of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing in Rats. I. FTY720 Selectively Decreases the Number of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing

1998 • 586 citations

SDZ RAD, A NEW RAPAMYCIN DERIVATIVE

1997 • 533 citations

Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1,3-propanediols: Discovery of a novel immunosuppressant, FTY720

1995 • 306 citations

A NOVEL IMMUNOSUPPRESSANT, FTY720, WITH A UNIQUE MECHANISM OF ACTION, INDUCES LONG-TERM GRAFT ACCEPTANCE IN RAT AND DOG ALLOTRANSPLANTATION1

1996 • 291 citations

FTY720, a Novel Immunosuppressant, Induces Sequestration of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing in Rats. II. FTY720 Prolongs Skin Allograft Survival by Decreasing T Cell Infiltration into Grafts But Not Cytokine Production In Vivo

1998 • 263 citations

FTY720, a novel immunosuppressant possessing unique mechanisms. I. Prolongation of skin allograft survival and synergistic effect in combination with cyclosporine in rats.

1996 • 127 citations

FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats, III. Increase in frequency of CD62L‐positive T cells in Peyer’s patches by FTY720‐induced lymphocyte homing

1998 • 114 citations

IMMUNOSUPPRESSIVE EFFECTS OF FTY720 ALONE OR IN COMBINATION WITH CYCLOSPORINE AND/OR SIROLIMUS1

1998 • 101 citations

PROPHYLAXIS OF ACUTE RENAL ALLOGRAFT REJECTION USING FTY720 IN COMBINATION WITH SUBTHERAPEUTIC DOSES OF CYCLOSPORINE1

1999 • 73 citations

FTY720, a novel immunosuppressant possessing unique mechanisms. II. Long-term graft survival induction in rat heterotopic cardiac allografts and synergistic effect in combination with cyclosporine A.

1996 • 71 citations

ORAL EFFICACY OF THE MACROLIDE IMMUNOSUPPRESSANT SDZ RAD AND OF CYCLOSPORINE MICROEMULSION IN CYNOMOLGUS MONKEY KIDNEY ALLOTRANSPLANTATION

2000 • 60 citations

The immunosuppressant rapamycin blocks in vitro responses to hematopoietic cytokines and inhibits recovering but not steady-state hematopoiesis in vivo

1994 • 51 citations

FTY720, a novel immunosuppressant possessing unique mechanisms. III. Synergistic prolongation of canine renal allograft survival in combination with cyclosporine A.

1996 • 49 citations

Immunosuppressive effect of a new drug, FTY720, on lymphocyte responses in vitro and cardiac allograft survival in rats

1996 • 48 citations

The macrolide SDZ RAD is efficacious in a nonhuman primate model of allotransplantation

1998 • 36 citations

A novel immunosuppressant, FTY720, induces peripheral lymphodepletion of both T- and B cells and immunosuppression in baboons

1999 • 29 citations

Preclinical evaluation of a new immunosuppressive agent, FTY720

1998 • 25 citations

A novel immunosuppressant, FTY720, increases the efficiency of a superantigen‐induced peripheral T‐cell deletion whilst inhibiting negative selection in the thymus

1998 • 18 citations

ROLE OF CYP4F IN THE METABOLIC CLEARANCE OF FTY720 - PREDICTION OF LOW DRUG TO DRUG INTERACTION POTENTIAL.

2000 • 10 citations

HUMAN PHARMACOKINETICS OF FTY 720

1999 • 10 citations

Neoral pharmacokinetics in cynomolgus monkeys: relation to efficacy in renal allografting.

1996 • 8 citations

Effects of rapamycin after syngeneic bone marrow transplantation in irradiated mice.

1996 • 1 citations