Evidence of Cosecretion of Islet Amyloid Polypeptide and Insulin by β-Cells

Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients.

1987 • 1,264 citations

Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells.

1987 • 957 citations

Co-localization of islet amyloid polypeptide and insulin in the B cell secretory granules of the human pancreatic islets

1989 • 364 citations

Islet amyloid in type 2 human diabetes mellitus and adult diabetic cats contains a novel putative polypeptide hormone.

1987 • 260 citations

An islet amyloid peptide is derived from an 89-amino acid precursor by proteolytic processing.

1988 • 256 citations

Immunolocalization of islet amyloid polypeptide (IAPP) in pancreatic beta cells by means of peroxidase-antiperoxidase (PAP) and protein A-gold techniques.

1988 • 195 citations

The insulin secretory granule

1989 • 188 citations

Hyperproinsulinemia and Amyloid in NIDDM: Clues to Etiology of Islet β-Cell Dysfunction?

1989 • 186 citations

Islet amyloid polypeptide inhibits glucose-stimulated insulin secretion from isolated rat pancreatic islets

1989 • 185 citations

Amyloidosis of the islets of Langerhans. A restudy of islet hyalin in diabetic and non-diabetic individuals.

1961 • 175 citations

Quantitative Studies of Amyloid in the Islets of Langerhans

1972 • 168 citations

Islet amyloid polypeptide (IAPP): cDNA cloning and identification of an amyloidogenic region associated with the species-specific occurrence of age-related diabetes mellitus

1989 • 124 citations

Studies of a Simplified Plasma Insulin Immunoassay Using Cellulose Powder

1968 • 123 citations

Rat amylin: cloning and tissue-specific expression in pancreatic islets.

1989 • 118 citations

Localisation of islet amyloid peptide in lipofuscin bodies and secretory granules of human B-cells and in islets of type-2 diabetic subjects

1989 • 112 citations

Amyloid in polypeptide hormone-producing tumors.

1977 • 112 citations

Impaired glucose tolerance is associated with increased islet amyloid polypeptide (IAPP) immunoreactivity in pancreatic beta cells.

1989 • 108 citations

Hyalinization of the islets of Langerhans in nondiabetic individuals.

1959 • 105 citations

Secretion of islet amyloid polypeptide in response to glucose

1989 • 104 citations

Use of Benzamidine as a Proteolytic Inhibitor in the Radioimmunoassay of Glucagon in Plasma

1972 • 92 citations

Structure of Cat Islet Amyloid Polypeptide and Identification of Amino Acid Residues of Potential Significance for Islet Amyloid Formation

1990 • 91 citations

Islet amyloid polypeptide (IAPP) and pro-IAPP immunoreactivity in human islets of Langerhans

1989 • 79 citations

Insular Amyloidosis and Diabetes Mellitus in Macaca Nigra

1978 • 77 citations

The complete islet amyloid polypeptide precursor is encoded by two exons

1989 • 73 citations

Somatostatin inhibits insulin and glucagon release by monolayer cell cultures of rat endocrine pancreas

1974 • 57 citations