Distribution of gelsolin and phosphoinositol 4,5-bisphosphate in lamellipodia during EGF-induced motility

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Cell Migration: A Physically Integrated Molecular Process

1996 • 3,909 citations

Actin-Based Cell Motility and Cell Locomotion

1996 • 1,536 citations

Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase

1998 • 1,384 citations

Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization

1998 • 1,263 citations

Actin Depolymerizing Factor (ADF/Cofilin) Enhances the Rate of Filament Turnover: Implication in Actin-based Motility

1997 • 1,028 citations

Cell adhesion and motility depend on nanoscale RGD clustering

2000 • 932 citations

Specific interaction between phosphatidylinositol 4,5-bisphosphate and profilactin

1985 • 824 citations

Phosphatidylinositol 4-Phosphate 5-Kinase α Is a Downstream Effector of the Small G Protein ARF6 in Membrane Ruffle Formation

1999 • 800 citations

Receptor-induced transient reduction in plasma membrane PtdIns(4,5)P2 concentration monitored in living cells

1998 • 733 citations

Phosphatidylinositol 4,5-Bisphosphate Functions as a Second Messenger that Regulates Cytoskeleton–Plasma Membrane Adhesion

2000 • 651 citations

Modulation of gelsolin function by phosphatidylinositol 4,5-bisphosphate

1987 • 624 citations

Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils.

1990 • 615 citations

Phosphoinositides and Calcium as Regulators of Cellular Actin Assembly and Disassembly

1994 • 524 citations

Regulation of vinculin binding to talin and actin by phosphatidyl-inositol-4-5-bisphosphate

1996 • 522 citations

The Actin-Binding Protein Profilin Binds to PIP ₂ and Inhibits Its Hydrolysis by Phospholipase C

1990 • 472 citations

Regulation of chemotaxis by the platelet-derived growth factor receptor-β

1994 • 441 citations

Ligand-Induced Transformation by a Noninternalizing Epidermal Growth Factor Receptor

1990 • 415 citations

Insulin-like growth factor-I and platelet-derived growth factor-BB induce directed migration of human arterial smooth muscle cells via signaling pathways that are distinct from those of proliferation.

1994 • 414 citations

Dynamics of capping protein and actin assembly in vitro: uncapping barbed ends by polyphosphoinositides.

1996 • 410 citations

Functions of gelsolin: motility, signaling, apoptosis, cancer

1999 • 373 citations

Epidermal growth factor receptor-mediated cell motility: phospholipase C activity is required, but mitogen-activated protein kinase activity is not sufficient for induced cell movement.

1994 • 333 citations

Enhanced Motility in NIH 3T3 Fibroblasts That Overexpress Gelsolin

1991 • 321 citations

Requirement of phosphatidylinositol 4,5-bisphosphate for α-actinin function

1992 • 320 citations

Conformation, Localization, and Integrin Binding of Talin Depend on Its Interaction with Phosphoinositides

2001 • 316 citations

Inhibition of the interactions of cofilin, destrin, and deoxyribonuclease I with actin by phosphoinositides.

1990 • 304 citations

Membrane ruffling and chemotaxis transduced by the PDGF beta-receptor require the binding site for phosphatidylinositol 3' kinase.

1994 • 303 citations

Variants of 3T3 cells lacking mitogenic response to epidermal growth factor.

1977 • 280 citations

Gelsolin is a downstream effector of rac for fibroblast motility

1998 • 267 citations

Regulation of Actin Polymerization by Arp2/3 Complex and WASp/Scar Proteins

1999 • 259 citations

Role of Cofilin in Epidermal Growth Factor–Stimulated Actin Polymerization and Lamellipod Protrusion

2000 • 245 citations

Cell movement elicited by epidermal growth factor receptor requires kinase and autophosphorylation but is separable from mitogenesis

1994 • 234 citations

Dictyostelium amoebae that lack G-actin-sequestering profilins show defects in F-actin content, cytokinesis, and development

1994 • 233 citations

Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues.

1992 • 231 citations

EGF receptor regulation of cell motility: EGF induces disassembly of focal adhesions independently of the motility-associated PLCγ signaling pathway

1998 • 231 citations

Identification of a polyphosphoinositide-binding sequence in an actin monomer-binding domain of gelsolin.

1992 • 224 citations

EGF stimulates an increase in actin nucleation and filament number at the leading edge of the lamellipod in mammary adenocarcinoma cells

1998 • 205 citations

Kinetic Analysis of the Interaction of Actin-depolymerizing Factor (ADF)/Cofilin with G- and F-Actins

1998 • 194 citations

A short sequence responsible for both phosphoinositide binding and actin binding activities of cofilin.

1991 • 181 citations

The three faces of profilin

1993 • 179 citations

Profilin: At the crossroads of signal transduction and the actin cytoskeleton

1994 • 172 citations

Biophysical Integration of Effects of Epidermal Growth Factor and Fibronectin on Fibroblast Migration

1999 • 155 citations

A role for gelsolin in actuating epidermal growth factor receptor-mediated cell motility.

1996 • 155 citations

Epidermal growth factor alters fibroblast migration speed and directional persistence reciprocally and in a matrix-dependent manner

1998 • 148 citations

Distribution of profilin in fibroblasts correlates with the presence of highly dynamic actin filaments

1992 • 146 citations

Effect of Epidermal Growth Factor Receptor Internalization on Regulation of the Phospholipase C-γ1 Signaling Pathway

1999 • 127 citations

D-myo-inositol 1,4,5-trisphosphate inhibits binding of phospholipase C-delta 1 to bilayer membranes.

1994 • 107 citations

Epidermal growth factor receptor-mediated motility in fibroblasts

1998 • 100 citations

Actin filaments are severed by both native and recombinantDictyostelium cofilin but to different extents

2000 • 83 citations

Real Time Fluorescence Imaging of Plcγ Translocation and Its Interaction with the Epidermal Growth Factor Receptor

2001 • 81 citations

Shaping up for shipping out: PLC? signaling of morphology changes in EGF-stimulated fibroblast migration

1999 • 80 citations

Actin assembly in response to extracellular signals: role of capping proteins, thymosin β4 and profilin

1994 • 75 citations

Coordinate Induction of the Actin Cytoskeletal Regulatory Proteins Gelsolin, Vasodilator-Stimulated Phosphoprotein, and Profilin during Capillary Morphogenesisin Vitro

1999 • 69 citations

Regulation of Profilin Localization in Saccharomyces cerevisiae by Phosphoinositide Metabolism

1995 • 63 citations

Detection of a sequence involved in actin-binding and phosphoinositide-binding in the N-terminal side of cofilin

1999 • 43 citations

Full-Contact Domain Labeling: Identification of a Novel Phosphoinositide Binding Site on Gelsolin That Requires the Complete Protein

2001 • 38 citations

Untitled

1999 • 35 citations

Immunocytochemical localization of gelsolin in fibroblasts, myogenic cells, and isolated myofibrils.

1994 • 23 citations