Cultured human skin fibroblasts: a model for the study of androgen action

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

Sex Chromosomes and Sex-linked Genes.

1968 • 1,363 citations

Steroid 5α-Reductase Deficiency in Man: An Inherited Form of Male Pseudohermaphroditism

1974 • 1,241 citations

Sex Chromosomes and Sex-Linked Genes

1967 • 1,050 citations

Wilkins the Diagnosis and Treatment of Endocrine Disorders in Childhood and Adolescence

1994 • 919 citations

Familial Incomplete Male Pseudohermaphroditism, Type 2

1974 • 617 citations

The syndrome of testicular feminization in male pseudohermaphrodites

1953 • 596 citations

X-linked Gene for Testicular Feminization in the Mouse

1970 • 551 citations

Androgens and the Evolution of Male-Gender Identity among Male Pseudohermaphrodites with 5α-Reductase Deficiency

1979 • 443 citations

Male pseudohermaphroditism due to steroid 5α-reductase deficiency

1977 • 390 citations

The Syndromes of Androgen Resistance

1980 • 314 citations

Androgens and antiandrogens

1978 • 305 citations

Mechanism of Action of the Sex Steroid Hormones

1976 • 288 citations

The conversion of testosterone to 5α-Androstan-17β-ol-3-one (dihydrotestosterone) by Skin Slices Of man

1969 • 276 citations

SYNDROME OF ANDROGEN INSENSITIVITY IN MAN: ABSENCE OF 5 α - DIHYDROTESTOSTERONE BINDING PROTEIN IN SKIN FIBROBLASTS.¹

1974 • 253 citations

Specific Estrogen Binding by the Cytoplasm of Human Breast Carcinoma

1970 • 234 citations

The Diagnosis and Treatment of Endocrine Disorders in Childhood and Adolescence

1951 • 233 citations

Dihydrotestosterone binding by cultured human fibroblasts. Comparison of cells from control subjects and from patients with hereditary male pseudohermaphroditism due to androgen resistance.

1976 • 231 citations

The Mechanism of Action of Androgens

1977 • 213 citations

IMPROVED SENSITIVITY: IN THE MEASUREMENT OF ESTROGEN RECEPTOR IN HUMAN BREAST CANCER

1973 • 211 citations

Cellular Receptors and Mechanisms of Action of Steroid Hormones

1975 • 192 citations

Locus on human X chromosome for dihydrotestosterone receptor and androgen insensitivity.

1975 • 182 citations

Part II. Androgen Metabolism and Mechanism of Action in Male Pseudohermaphroditism: A Study of Testicular Feminization

1973 • 180 citations

Male pseudohermaphroditism: The complexities of male phenotypic development

1976 • 156 citations

Sexual Differentiation

1978 • 156 citations

Androgen insensitivity in man: evidence for genetic heterogeneity.

1976 • 152 citations

In vitro metabolism of testosterone-4-¹⁴C and Δ⁴-androstene-3,17-dione-4¹⁴C in human skin

1968 • 135 citations

Testicular Feminization Associated with a Thermolabile Androgen Receptor in Cultured Human Fibroblasts

1979 • 135 citations

Genetic mechanisms of sexual development

1980 • 134 citations

Dihydrotestosterone formation in cultured human fibroblasts. Comparison of cells from normal subjects and patients with familial incomplete male pseudohermaphroditism, Type 2.

1975 • 124 citations

Diminished 5alpha-reductase activity in extracts of fibroblasts cultured from patients with familial incomplete male pseudohermaphroditism, type 2.

1975 • 111 citations

FAMILIAL MALE PSEUDOHERMAPHRODISM WITH LABIAL TESTES AND PARTIAL FEMINIZATION: ENDOCRINE STUDIES AND GENETIC ASPECTS

1959 • 110 citations

Androgen receptor in human skin fibroblasts characterization of a specific 17β-hydroxy-5α-androstan-3-one-protein complex in cell sonicates and nuclei

1975 • 108 citations

Steroid 5α-Reductase Deficiency in a 65-Year-Old Male Pseudohermaphrodite: The Natural History, Ultrastructure of the Testes, and Evidence for Inherited Enzyme Heterogeneity*

1980 • 107 citations

Partial Androgen Insensitivity

1977 • 104 citations

Male pseudohermaphroditism presumably due to target organ unresponsiveness to androgens. Deficient 5alpha-dihydrotestosterone binding in cultured skin fibroblasts.

1976 • 103 citations

X‐Linked testicular feminization in the mouse as a non‐inducible regulatory mutation of the Jacob‐Monod type

1970 • 103 citations

Advances in Human Genetics 9

1979 • 100 citations

Steroid 5alpha-reductase in cultured human fibroblasts. Biochemical and genetic evidence for two distinct enzyme activities.

1976 • 99 citations

Hereditary familial hypogonadism.

1947 • 95 citations

Binding of [3H] methyltrienolone (R 1881) in rat prostate and human benign prostatic hypertrophy (BPH)

1976 • 94 citations

Hereditary Male Pseudohermaphroditism Associated with an Unstable Form of 5α-Reductase

1978 • 94 citations

Characterization of the Binding of a Potent Synthetic Androgen, Methyltrienolone, to Human Tissues

1978 • 93 citations

Clinical, Endocrinological, and Enzymatic Characterization of Two Patients with 5α-Reductase Deficiency: Evidence that a Single Enzyme Is Responsible for the 5α-Reduction of Cortisol and Testosterone*

1978 • 92 citations

Two distinct groups of immunoglobulin A(IgA) revealed by peptic digestion

1969 • 87 citations

Hereditary Male Pseudohermaphroditism with Hypogonadism, Hypospadias, and Gynecomastia

1965 • 83 citations

Studies on the Pathogenesis of the Incomplete Forms of Androgen Resistance in Man

1977 • 78 citations

Pseudohermaphrodite Rat: End Organ Insensitivity to Testosterone

1970 • 78 citations

A dispersed-whole cell method for the determination of androgen receptors in human skin fibroblasts

1980 • 73 citations

Characterization of unoccupied (R) and occupied (RA) androgen binding components of the hyperplastic human prostate

1978 • 63 citations

TESTOSTERONE 5α-REDUCTION IN THE SKIN OF NORMAL SUBJECTS AND OF PATIENTS WITH ABNORMAL SEX DEVELOPMENT

1975 • 61 citations

Familial Gynecomastia

1965 • 59 citations

Qualitative differences in testosterone metabolism as an indication of cellular heterogeneity in fibroblast monolayers derived from human preputial skin

1975 • 57 citations

Sexual Differentiation: Early Hormone Synthesis and Action1

1980 • 53 citations

ANDROGEN RECEPTORS AND METABOLISM IN CULTURED HUMAN FETAL FIBROBLASTS

1980 • 48 citations

Role of testosterone binding to the androgen receptor in male sexual differentiation of patients with 5α-reductase deficiency

1979 • 47 citations

ANDROGEN BINDING IN CYTOSOLS AND NUCLEI OF HUMAN BENIGN HYPERPLASTIC PROSTATIC TISSUE

1978 • 43 citations

The In Vitro Metabolism of Testosterone by Human Skin1

1956 • 41 citations

Intranuclear Binding of [³H]Dihydrotestosterone by Cultured Human Fibroblasts*

1978 • 35 citations

Complete androgen insensitivity with a normal amount of 5α‐dihydrotestosterone‐binding activity in labium majus skin fibroblasts

1979 • 35 citations

Expression of androgen-responsive properties in human skin fibroblast strains of genital and nongenital origin

1977 • 33 citations

5α‐Reductase activity of genital and nongenital skin fibroblasts from patients with 5α‐reductase deficiency, androgen insensitivity, or unknown forms of male pseudohermaphroditism

1978 • 33 citations

Metabolism of 4-¹⁴C-Testosterone by Serially Subcultured Human Skin Fibroblasts1

1972 • 31 citations

Metabolism of testosterone-14C by cultured human cells

1972 • 30 citations

Comparison of the Metabolism and Receptor Binding of Testosterone and 17β-Hydroxy-5α-Androstan-3-One in Normal Skin Fibroblast Cultures: Influence of Origin and Passage Number

1979 • 27 citations

[Case of familial androgynism with severe hypospadias, gynecomastia and excessive estrogen production].

1957 • 26 citations

Testosterone 5α-reductase activity of skin fibroblasts increase with serial subcultures

1980 • 25 citations

Studies of Androgen Production and Binding in 13 Male Pseudohermaphrodites and 13 Males with Micropenis

1977 • 24 citations

Selective inhibition by secosteroids of 5α-reductase activity in human sex skin fibroblasts

1979 • 19 citations

LACK OF DIFFERENCE IN TESTOSTERONE METABOLISM BETWEEN CULTURED SKIN FIBROBLASTS OF HUMAN ADULT MALES AND FEMALES

1974 • 17 citations

Numerical Taxonomy of Birth Defects and Polygenic Disorders.

1978 • 14 citations

Genetic Disorders of Male Sexual Differentiation

1980 • 11 citations

Some Properties of the Specific Androgen-Binding Activities in Cultured Human Genital Skin Fibroblasts*

1978 • 11 citations

A New Method for the Characterization of the Androgen Receptors by use of a Steroid Antibody

1974 • 9 citations

Antibody method for measurement of dihydrotestosterone receptors in cultured human skin fibroblasts.

1979 • 7 citations

Numerical taxonomy of birth defects and polygenic disorders

1977 • 4 citations