Male pseudohermaphroditism: The complexities of male phenotypic development

The Developing Human: Clinically Oriented Embryology

1973 • 2,105 citations

Textbook of Endocrinology

1952 • 1,475 citations

Sex Chromosomes and Sex-linked Genes.

1968 • 1,363 citations

Steroid 5α-Reductase Deficiency in Man: An Inherited Form of Male Pseudohermaphroditism

1974 • 1,241 citations

Female Steroid Hormones and Target Cell Nuclei

1974 • 946 citations

Wilkins the Diagnosis and Treatment of Endocrine Disorders in Childhood and Adolescence

1994 • 919 citations

Hormonal control of mammalian spermatogenesis.

1971 • 682 citations

Familial Incomplete Male Pseudohermaphroditism, Type 2

1974 • 617 citations

The syndrome of testicular feminization in male pseudohermaphrodites

1953 • 596 citations

Steroid–Cell Interactions

1974 • 592 citations

Testosterone Formation and Metabolism During Male Sexual Differentiation in the Human Embryo

1974 • 592 citations

17-hydroxylation deficiency in man.

1966 • 562 citations

Studies on Sex Differentiation in Mammals

1973 • 558 citations

Gene‐induced embryological modifications of primordial germ cells in the mouse

1957 • 556 citations

X-linked Gene for Testicular Feminization in the Mouse

1970 • 551 citations

The Developing Human: Clinically Oriented Embryology

1973 • 537 citations

Karyotype-phenotype Correlations in Gonadal Dysgenesis and Their Bearing on the Pathogenesis of Malformations

1965 • 516 citations

The anatomy and histology of XO human embryos and fetuses

1966 • 446 citations

Dihydrotestosterone in prostatic hypertrophy

1970 • 409 citations

Male pseudohermaphroditism due to steroid 5α-reductase deficiency

1977 • 390 citations

Development of Vertebrates

1957 • 379 citations

Studies on Human Sexual Development. II. Fetal and Maternal Serum Gonadotropin and Sex Steroid Concentrations¹

1974 • 373 citations

X-Y CHROMOSOMAL INTERCHANGE IN THE ÆTIOLOGY OF TRUE HERMAPHRODITISM AND OF XX KLINEFELTER'S SYNDROME

1966 • 369 citations

SEVERE HEAD INJURIES

1967 • 352 citations

Enzyme synthesis and degradation in mammalian systems

1971 • 310 citations

Differential Rates of Conversion of Testerone to Dihydrotestosterone In Acne and in Normal Human Skin- a Possible Pathogenic Factor in Acne

1971 • 297 citations

Copulation in Castrated Male Rats following Combined Treatment with Estradiol and Dihydrotestosterone

1973 • 292 citations

The conversion of testosterone to 5α-Androstan-17β-ol-3-one (dihydrotestosterone) by Skin Slices Of man

1969 • 276 citations

Aspects of Androgen-Dependent Events as Studied by Antiandrogens

1970 • 270 citations

CYTOGENETIC STUDIES IN PRIMARY AMENORRH$OElig;A

1961 • 267 citations

Gonadoblastoma associated with pure gonadal dysgenesis in monozygous twins

1964 • 265 citations

Analytic review: nature and origin of males with XX sex chromosomes.

1972 • 254 citations

SYNDROME OF ANDROGEN INSENSITIVITY IN MAN: ABSENCE OF 5 α - DIHYDROTESTOSTERONE BINDING PROTEIN IN SKIN FIBROBLASTS.¹

1974 • 253 citations

Semi-security and psychiatric hospitals.

1974 • 240 citations

Estradiol and Testosterone Secretion by Human, Simian, and Canine Testes, in Males with Hypogonadism and in Male Pseudohermaphrodites with the Feminizing Testes Syndrome

1972 • 232 citations

FURTHER OBSERVATIONS ON THE SYNDROME, "TESTICULAR FEMINIZATION".

1963 • 227 citations

Evolutionary conservation of H-Y (‘male’) antigen

1975 • 215 citations

Male pseudohermaphroditism due to 17α-hydroxylase deficiency

1970 • 210 citations

Failure of 5α-Dihydrotestosterone to initiate Sexual Behaviour in the Castrated Male Rat

1970 • 193 citations

Structural Abnormalities of the Y Chromosome in Man

1966 • 183 citations

Part II. Androgen Metabolism and Mechanism of Action in Male Pseudohermaphroditism: A Study of Testicular Feminization

1973 • 180 citations

Dihydrotestosterone Formation in Fetal Tissues of the Rabbit and Rat

1971 • 175 citations

Estrogen formation in the brain

1972 • 175 citations

Familial Male Pseudohermaphroditism with Gynecomastia Due to a Testicular 17-Ketosteroid Reductase Defect. I. Studiesin Vivo

1971 • 172 citations

The Diagnosis and Treatment of Endocrine Disorders in Childhood and Adolescence

1958 • 171 citations

Source of the Anti-müllerian Hormone Synthesized by the Fetal Testis: Müllerian-inhibiting Activity of Fetal Bovine Sertoli Cells in Tissue Culture

1974 • 170 citations

Studies on the Role of Sex Steroids in the Feedback Control of FSH Concentrations in Men1

1973 • 169 citations

Studies on Human Sexual Development. I. Fetal Gonadal and Adrenal Sex Steroids¹

1973 • 167 citations

The Source of Plasma Dihydrotestosterone in Man

1971 • 167 citations

STEROID 17, 20‐DESMOLASE DEFICIENCY: A NEW CAUSE OF MALE PSEUDOHERMAPHRODITISM

1972 • 161 citations

Studies on the pathogenesis of the pseudohermaphroditism in the mouse with testicular feminization

1972 • 156 citations

THYROID-ANDROGEN INTERRELATIONS AND THE HYPOCHOLESTEREMIC EFFECT OF ANDROSTERONE*

1959 • 155 citations

Hypogonadism and Mineralocorticoid Excess

1967 • 152 citations

Male Pseudohermaphroditism Due to Testicular 17β-Hydroxysteroid Dehydrogenase Deficiency1

1973 • 147 citations

Testosterone Cytosol “Receptor” in the Rat Levator Ani Muscle

1972 • 142 citations

MIXED GONADAL DYSGENESIS

1973 • 140 citations

Steroid 5alpha-reductase deficiency in man. An inherited form of male pseudohermaphroditism.

1975 • 137 citations

The Feedback Control of Luteinizing Hormone in Normal Adult Men

1974 • 123 citations

The metabolic clearance rate and origin of plasma dihydrotestosterone in man and its conversion to the 5α-androstanediols

1971 • 121 citations

Familial Syndrome of Streak Gonads and Normal Male Karyotype in Five Phenotypic Females

1970 • 116 citations

Familial Occurrence of Persistent Mullerian Structures in Otherwise Normal Males

1973 • 112 citations

Studies on testosterone metabolism in subjects with testicular feminization syndrome

1970 • 111 citations

FAMILIAL MALE PSEUDOHERMAPHRODISM WITH LABIAL TESTES AND PARTIAL FEMINIZATION: ENDOCRINE STUDIES AND GENETIC ASPECTS

1959 • 110 citations

The pathology and cytogenetics of gonadal agenesis

1963 • 109 citations

WHIPLASH INJURY AND SUBDURAL HÆMATOMA

1969 • 106 citations

Topographical Location of H—Y Antigen on Mouse Spermatozoa by Immunoelectronmicroscopy

1973 • 102 citations

Characterization of a hormone receptor defect in the androgen-insensitivity mutant

1974 • 102 citations

Congenital Adrenal Hyperplasia Secondary to 17-Hydroxylase Deficiency

1969 • 102 citations

Familial Xy Gonadal Dysgenesis

1968 • 97 citations

An Explanation for the Target Organ Unresponsiveness to Testosterone in the Testicular Feminization Syndrome

1969 • 96 citations

Hereditary familial hypogonadism.

1947 • 95 citations

Genetic intersexuality in goats.

1969 • 92 citations

EVIDENCE FOR DEFICIENT 20α-CHOLESTEROL-HYDROXYLASE ACTIVITY IN ADRENAL TISSUE OF A PATIENT WITH LIPOID ADRENAL HYPERPLASIA

1972 • 91 citations

Metabolic clearance rate and blood production rate of testosterone and dihydrotestosterone in normal subjects, during pregnancy, and in hyperthyroidism

1972 • 90 citations

Congenital Adrenal Hyperplasia Due to a Deficiency of One of the Enzymes Involved in the Biosynthesis of Pregnenolone

1968 • 89 citations

Chromosome Studies on Bone Marrow from a Male Control Population

1970 • 88 citations

UNUSUAL STEROID PATTERN IN CONGENITAL ADRENAL HYPERPLASIA; DEFICIENCY OF 3β-HYDROXY DEHYDROGENASE

1961 • 87 citations

Serological Crossreactivity Between H-Y (Male) Antigens of Mouse and Man

1974 • 85 citations

Hereditary Male Pseudohermaphroditism with Hypogonadism, Hypospadias, and Gynecomastia

1965 • 83 citations

Furtherin VivoStudies in Male Pseudohermaphroditism with Gynecomastia Due to a Testicular 17-Ketosteroid Reductase Defect (Compared to a Case of Testicular Feminization)

1972 • 82 citations

Congenital Lipoid Adrenal Hyperplasia in an Eight-Year-Old Phenotypic Female

1973 • 82 citations

Androgen and Gonadotropin Dynamics in Testicular Feminization Syndrome

1972 • 81 citations

Permeability of Membranes to the Müllerian-Inhibiting Substance Synthesized by the Human Fetal Testisin Vitro: A Clue to its Biochemical Nature

1972 • 81 citations

Gonadal dysgenesis in individuals with apparently normal chromosomal complements: tabulation of cases and compilation of genetic data.

1971 • 81 citations

Development of the Genital System and Male Pseudohermaphroditism.

1971 • 79 citations

Further Evidence of a Target Organ Defect in the Syndrome of Testicular Feminization1

1966 • 78 citations

Observational and experimental evidences relating to the origin and differentiation of the definitive germ cells in mice

1943 • 77 citations

Alterations in fibrinolysis and blood coagulation.

1969 • 75 citations

HÆMOPHILIA A IN A "GIRL" WITH MALE SEX-CHROMATIN PATTERN

1959 • 75 citations

Familial Male Pseudohermaphroditism without Gynecomastia Due to Deficient Testicular 17-Ketosteroid Reductase Activity

1974 • 75 citations

GONADAL HISTOLOGY IN PATIENTS WITH MALE PSEUDOHERMAPHRODITISM AND ATYPICAL GONADAL DYSGENESIS: RELATION TO THEORIES OF SEX DIFFERENTIATION

1962 • 74 citations

Pseudovaginal perineoscrotal hypospadias

1972 • 72 citations

Two XY Siblings with Gonadal Dysgenesis and a Female Phenotype

1965 • 71 citations

Persistent testicular delta5-isomerase-3beta-hydroxysteroid dehydrogenase (delta5-3beta-HSD) deficiency in the delta5-3beta-HSD form of congenital adrenal hyperplasia.

1975 • 70 citations

Abnormal Sexual Development. A Genetic and Endocrine Approach to the Differential Diagnosis.

1968 • 69 citations

The Endocrine Society 66th Annual Meeting

1984 • 67 citations

Male pseudohermaphroditism and pure gonadal dysgenesis in sisters

1967 • 67 citations

STRUCTURAL ABNORMALITIES OF THE SEX CHROMOSOMES

1969 • 65 citations

PLASMA CONCENTRATION OF TESTOSTERONE, DIHYDROTESTOSTERONE, TESTOSTERONE-OESTRADIOL BINDING GLOBULIN, AND PITUITARY GONADOTROPHINS IN THE SYNDROME OF MALE PSEUDO-HERMAPHRODITISM WITH TESTICULAR FEMINIZATION

1972 • 65 citations

Unusual Type of Congenital Adrenal Hyperplasia Probably Due to Deficiency of 3β-Hydroxysteroid Dehydrogenase. Case Report of a Surviving Girl and Steroid Studies¹

1970 • 64 citations

The Control of Gonadotropin Secretion in Complete Testicular Feminization¹

1974 • 63 citations

Male Pseudohermaphroditism Consistent with 17,20-Desmolase Deficiency

1976 • 62 citations

Studies of Androgens in Patients with Congenital Adrenal Hyperplasia

1967 • 61 citations

Familial XY gonadal dysgenesis.

1970 • 61 citations

A New Male Pseudohermaphroditism Associated with Hypertension due to a Block of 17α-Hydroxylation

1972 • 60 citations

ELECTRON MICROSCOPIC OBSERVATIONS OF THE GONAD IN THE TESTICULAR FEMINIZATION SYNDROME.

1964 • 59 citations

Studies on the Biosynthetic Conversion of Cholesterol into Pregnenolone

1972 • 59 citations

Estrogen Formation by the Isolated Perfused Rhesus Monkey Brain

1973 • 58 citations

Splanchnic Extraction and Interconversion of Testosterone and Androstenedione in Man*

1967 • 51 citations

Absence of Response to Dihydrotestosterone in the Syndrome of Testicular Feminization

1969 • 51 citations

Studies of Androgens in the Syndrome of Male Pseudohermaphroditism with Testicular Feminization

1967 • 50 citations

Studies on the Biosynthetic Conversion of Cholesterol into Pregnenolone

1974 • 50 citations

A Form of Lipoidosis of the Adrenal Cortex in an Infant

1955 • 48 citations

PARTIAL 3β-HYDROXYSTEROID DEHYDROGENASE (3β-HSD) DEFICIENCY IN A FAMILY WITH CONGENITAL ADRENAL HYPERPLASIA: EVIDENCE FOR INCREASING 3β-HSD ACTIVITY WITH AGE

1971 • 47 citations

45,X cell lines in adult men: loss of Y chromosome, a normal aging phenomenon?

1971 • 47 citations

THE EFFECT OF THE ANTI-ANDROGEN 1,2α-METHYLENE-6-CHLORO-Δ4,6-PREGNADIENE-17α-OL-3,20-DIONE-17α-ACETATE (CYPROTERONE ACETATE) ON THE DEVELOPMENT OF THE MAMMARY GLANDS OF MALE FOETAL RATS

1966 • 46 citations

CONTRIBUTION TO THE STUDY OF THE SO-CALLED PURE GONADAL DYSGENESIS

1965 • 45 citations

XY/XO MOSAICISM

1962 • 44 citations

Blood Production Rate of Dihydrotestosterone in the Syndrome of Male Pseudohermaphroditism with Testicular Feminization

1972 • 43 citations

Decreased Conversion of Androgens to Normal 17-Ketosteroid Metabolites: A Nonspecific Consequence of Illness

1971 • 42 citations

STUDIES IN PORPHYRIA

1972 • 42 citations

Transformation of labeled cholesterol, 20α-hydroxycholesterol, (22R)-22-hydroxycholesterol, and (22R)-20α, 22-dihydroxycholesterol by adrenal acetone-dried preparations from Guinea pigs, cattle and man: II. Kinetic studies

1970 • 41 citations

Androgens and Androgen Responsiveness in the Feminizing Testis Syndrome. Comparison of Complete and “Incomplete” Forms¹

1971 • 41 citations

CHROMOSOMAL STUDIES IN SOME VARIANTS OF MALE PSEUDOHERMAPHRODITISM

1961 • 41 citations

Milk: The Mammary Gland and Its Secretions

1961 • 33 citations

MIXED GONADAL DYSGENESIS

1975 • 33 citations

XX/XO MOSAICISM

1963 • 32 citations

Modification of Expression of the Testicular feminization (Tfm) Gene of the Mouse by a “Controlling Element” Gene

1973 • 31 citations

Two male sibs with uterus and Fallopian tubes. A rare, probably inherited disorder

1973 • 29 citations

The fine structure of the gonads in the complete form of testicular feminization syndrome

1972 • 29 citations

TESTICULAR FEMINISATION AND COLOUR-BLINDNESS

1959 • 27 citations

3 : 21-Dihydroxypregn-5-ene-20-one in Urine of Normal Newborn Infants and in Third Day Urine of Child with Deficiency of 3 -hydroxysteroid-dehydrogenase

1965 • 27 citations

XO/XY Chromosomal Mosaicism and Extragenital Stigmata of Turner's Syndrome in a Phenotypic Male

1965 • 27 citations

[Case of familial androgynism with severe hypospadias, gynecomastia and excessive estrogen production].

1957 • 26 citations

Genetic Forms of Hypogonadism

1976 • 25 citations

LIPOID ADRENAL HYPERPLASIA.

1964 • 23 citations

Testicular Endocrine Function in a Pubertal Boy with 3β-Hydroxysteroid Dehydrogenase Deficiency

1974 • 23 citations

Males with a uterus and fallopian tubes, a rare disorder of sexual development.

1971 • 22 citations

Four Clinical Variants of Congenital Adrenal Hyperplasia

1964 • 21 citations

[Arterial hypertension, hypokalemic alkalosis and male pseudohermaphroditism caused by 17 alpha-hydroxylase deficiency].

1971 • 21 citations

Further Studies on the Pathophysiology of Testicular Feminization Syndrome¹

1971 • 20 citations

Abnormal sexual development. A genetic and endocrine approach to differential diagnosis.

1968 • 19 citations

FLUORESCENCE AND Y TRANSLOCATION IN XX MALES

1971 • 19 citations

THE METABOLISM OF TESTOSTERONE BY SKIN IN NORMAL SUBJECTS AND IN TESTICULAR FEMINIZATION

1971 • 18 citations

DRUG‐INDUCED ALTERATIONS OF STEROID HORMONE METABOLISM IN MAN*

1973 • 17 citations

Testicular Feminization: An Apparent Enzyme Defect

1969 • 14 citations

Testicular feminization syndrome. Chromosomal, histologic, and genetic studies in a large kindred.

1969 • 13 citations

TESTING THE HYPOTHESIS OF Y TRANSLOCATION IN XX MALES BY FLUORESCENCE MICROSCOPY AFTER QUINACRINE-DIHYDROCHLORIDE STAINING

1971 • 13 citations

Metabolic studies in a patient with testicular feminization syndrome

1971 • 12 citations

THE EXCRETION OF INDIVIDUAL 17-OXOSTEROIDS IN CUSHING'S SYNDROME

1961 • 12 citations

Inheritance of testicular feminization syndrome: some negative linkage findings.

1969 • 12 citations

Reifenstein's syndrome: Investigation of linkage to X‐chromosomal loci

1974 • 11 citations

About intersexuality and adrenal hyperplasia.

1948 • 10 citations

EFFECT OF CORTICOSTEROIDS ON URINARY 5β AND 5α C19 STEROIDS IN MAN

1964 • 8 citations

Fluorescing structures of human metaphase chromosomes. Detection of "Y body".

1971 • 8 citations

Cytogenetic studies in primary amenorrhea.

1976 • 7 citations

Human parathyroid gland immunoreactive peptides--evidence for proparathormone.

1971 • 7 citations

Testosterone metabolism and androgenic effect.

1972 • 4 citations

FORMATION AND METABOLISM OF 5α-REDUCED STEROIDS BY GONADAL TISSUE IN TESTICULAR FEMINIZATION

1974 • 1 citations