A method to codetect introduced genes and their products in gene therapy protocols

Direct Gene Transfer into Mouse Muscle in Vivo

1990 • 3,985 citations

T Lymphocyte-Directed Gene Therapy for ADA ⁻ SCID: Initial Trial Results After 4 Years

1995 • 1,464 citations

High-Resolution Mapping of Human Chromosome 11 by in Situ Hybridization with Cosmid Clones

1990 • 1,357 citations

Isolation of candidate cDNAs for portions of the Duchenne muscular dystrophy gene

1986 • 1,033 citations

Transfer of Genes to Humans: Early Lessons and Obstacles to Success

1995 • 1,023 citations

Neuropathological Evidence of Graft Survival and Striatal Reinnervation after the Transplantation of Fetal Mesencephalic Tissue in a Patient with Parkinson's Disease

1995 • 857 citations

Gene Therapy in Peripheral Blood Lymphocytes and Bone Marrow for ADA ⁻ Immunodeficient Patients

1995 • 846 citations

Survival of Implanted Fetal Dopamine Cells and Neurologic Improvement 12 to 46 Months after Transplantation for Parkinson's Disease

1992 • 757 citations

Detection of 98% of DMD/BMD gene deletions by polymerase chain reaction

1990 • 677 citations

Positional cloning moves from perditional to traditional

1995 • 603 citations

Widespread long-term gene transfer to mouse skeletal muscles and heart.

1992 • 586 citations

A Controlled Study of Adenoviral-Vector–Mediated Gene Transfer in the Nasal Epithelium of Patients with Cystic Fibrosis

1995 • 571 citations

Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolaemia

1994 • 562 citations

Myoblast Transfer in the Treatment of Duchenne's Muscular Dystrophy

1995 • 513 citations

Bilateral Fetal Mesencephalic Grafting in Two Patients with Parkinsonism Induced by 1-Methyl-4-Phenyl-L,2,3,6-Tetrahydropyridine (MPTP)

1992 • 499 citations

Normal dystrophin transcripts detected in Duchenne muscular dystrophy patients after myoblast transplantation

1992 • 429 citations

A Defective HSV-1 Vector Expresses Escherichia coli β-Galactosidase in Cultured Peripheral Neurons

1988 • 417 citations

Localization of dystrophin to postsynaptic regions of central nervous system cortical neurons

1990 • 413 citations

Fluorescence in situ hybridization: applications in cytogenetics and gene mapping

1991 • 375 citations

Long-Term Behavioral Recovery in Parkinsonian Rats by an HSV Vector Expressing Tyrosine Hydroxylase

1994 • 333 citations

Systemic Delivery of Human Growth Hormone by Injection of Genetically Engineered Myoblasts

1991 • 324 citations

Myoblast transfer in duchenne muscular dystrophy

1993 • 304 citations

Human chromosomes. Manual of basic techniques

1990 • 286 citations

Helper virus-free transfer of herpes simplex virus type 1 plasmid vectors into neural cells

1996 • 277 citations

Rapid detection of human chromosome 21 aberrations by in situ hybridization.

1988 • 251 citations

Human myoblast transplantation: Preliminary results of 4 cases

1992 • 248 citations

The subcellular distribution of dystrophin in mouse skeletal, cardiac, and smooth muscle.

1991 • 228 citations

A differential efficiency of adenovirus-mediated in vivo gene transfer into skeletal muscle cells of different maturity

1994 • 209 citations

An efficient deletion mutant packaging system for defective herpes simplex virus vectors: potential applications to human gene therapy and neuronal physiology.

1990 • 203 citations

Infection of cultured central nervous system neurons with a defective herpes simplex virus 1 vector results in stable expression of Escherichia coli beta-galactosidase.

1990 • 146 citations

Long-term expression of human adenosine deaminase in vascular smooth muscle cells of rats: a model for gene therapy.

1992 • 134 citations

Gene Therapy — A Novel Form of Drug Delivery

1995 • 121 citations

Muscle-Mediated Gene Therapy

1995 • 104 citations

Long-term increases in neurotransmitter release from neuronal cells expressing a constitutively active adenylate cyclase from a herpes simplex virus type 1 vector.

1993 • 98 citations

Gene Transfer to the Thymus A Means of Abrogating the Immune Response to Recombinant Adenovirus

1995 • 72 citations

Identification and characterization of a gene regulating enzymatic glycosylation which is induced by diabetes and hyperglycemia specifically in rat cardiac tissue.

1995 • 65 citations

Fluorescence in situ hybridization combined with immunohistochemistry for highly sensitive detection of chromosome 1 aberrations in neuroblastoma

1993 • 63 citations

Combined immunocytochemistry and fluorescence in situ hybridization for simultaneous tricolor detection of cell cycle, genomic, and phenotypic parameters of tumor cells.

1994 • 43 citations

Skeletal Muscle Pathology.

1983 • 31 citations

New methods in cytogenetics

1994 • 26 citations

Morphological identification and biochemical characterization of isolated brain cell nuclei from the developing rat cerebellum

1979 • 24 citations

Simultaneous detection of HBV-specific antigens and DNA in paraffin-embedded liver tissue by immunohistochemistry and in situ hybridization using a digoxigenin-labeled probe

1992 • 23 citations

Co-localization of EGF transcripts and peptides by combined immunohistochemistry and in situ hybridization.

1990 • 19 citations

In situ hybridization and β-galactosidase: a powerful combination for analysing transgenic mice

1995 • 19 citations

Combination of alkaline phosphatase in situ hybridization with immunohistochemistry: colocalization of calretinin-mRNA with calbindin and tyrosine hydroxylase immunoreactivity in rat substantia nigra neurons

1994 • 16 citations

Chronic imipramine diminishes the nuclear size of neurons in the locus coeruleus and cingular cortex but not in the hippocampus of the rat brain

1988 • 14 citations

Analysis of phenotype and genotype of individual cells in neoplasms

1993 • 13 citations

Computer assisted signal co-localization for simultaneous detection of antigen by immunohistochemistry and DNA by non-isotopic in situ hybridization

1993 • 6 citations

Simultaneous detection of neuropeptides and messenger RNA in the magnocellular hypothalamo-neurohypophysial system by a combination of non-radioactive in situ hybridization histochemistry and immunohistochemistry

1994 • 5 citations