Loss of Cytoplasmic Retention Ability of Mutant LKB1 Found in Peutz-Jeghers Syndrome Patients

A serine/threonine kinase gene defective in Peutz–Jeghers syndrome

1998 • 1,588 citations

Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: Identification of a class of bipartite nuclear targeting sequence

1991 • 1,501 citations

Peutz-Jeghers syndrome is caused by mutations in a novel serine threoninekinase

1998 • 1,176 citations

Mutations in the SMAD4/DPC4 Gene in Juvenile Polyposis

1998 • 901 citations

Increased Risk of Cancer in the Peutz–Jeghers Syndrome

1987 • 865 citations

Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis

1997 • 487 citations

Peutz-Jeghers syndrome.

1997 • 325 citations

Cancer and the Peutz-Jeghers syndrome.

1989 • 322 citations

Loss of LKB1 Kinase Activity in Peutz-Jeghers Syndrome, and Evidence for Allelic and Locus Heterogeneity

1998 • 212 citations

A Novel Regulatory Mechanism in the Mitogen-activated Protein (MAP) Kinase Cascade

1997 • 181 citations

Pathogenesis of adenocarcinoma in Peutz-Jeghers syndrome.

1998 • 181 citations

Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer

1999 • 159 citations

Peutz-Jeghers syndrome: 78-year follow-up of the original family

1999 • 152 citations

LKB1 Somatic Mutations in Sporadic Tumors

1999 • 128 citations

Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma

1999 • 126 citations

Somatic Mutations in the Peutz-Jegners (LKB1/STKII) Gene in Sporadic Malignant Melanomas

1999 • 100 citations

STK11 mutations in Peutz-Jeghers syndrome and sporadic colon cancer.

1998 • 92 citations

Frequent somatic mutations in serine/threonine kinase 11/Peutz-Jeghers syndrome gene in left-sided colon cancer.

1998 • 89 citations

Cloning and Characterization of a Novel Serine/Threonine Protein Kinase Expressed in Early Embryos

1996 • 87 citations

Nine novel germline mutations of STK11 in ten families with Peutz-Jeghers syndrome

1998 • 72 citations

Mutations of the STK11 gene in sporadic gastric carcinoma.

1998 • 48 citations

Peutz-Jeghers Syndrome: Molecular Analysis of a Three-Generation Kindred With a Novel Defect in the Serine Threonine Kinase Gene STK11

1999 • 33 citations

The genetics of hereditary common cancers

1998 • 29 citations

Peutz-Jeghers syndrome: Four novel inactivating germline mutations in theSTK11 gene

1999 • 25 citations