Platelet membrane phosphatidylinositol-4,5-bisphosphate alterations in bipolar disorder — evidence from a single case study

A Diagnostic Interview

1978 • 5,735 citations

The Bech‐Rafaelsen Mania Scale and the Hamilton Depression Scale

1979 • 392 citations

Signal Transduction Pathways

1995 • 328 citations

Alterations in brain phosphorous metabolism in bipolar disorder detected by in vivo 31P and 7Li magnetic resonance spectroscopy

1993 • 227 citations

Reduction of brain phosphocreatine in bipolar II disorder detected by phosphorus-31 magnetic resonance spectroscopy

1994 • 219 citations

Brain phosphorous metabolism in depressive disorders detected by phosphorus-31 magnetic resonance spectroscopy

1992 • 200 citations

Altered platelet protein kinase C activity in bipolar affective disorder, manic episode

1993 • 197 citations

Increased Platelet Intracellular Calcium Concentration in Patients With Bipolar Affective Disorders

1989 • 184 citations

Cerebral Cortex G_sα Protein Levels and Forskolin‐Stimulated Cyclic AMP Formation Are Increased in Bipolar Affective Disorder

1993 • 159 citations

Abnormal frontal lobe phosphorous metabolism in bipolar disorder

1995 • 155 citations

CNS signal transduction in the pathophysiology and pharmacotherapy of affective disorders and schizophrenia

1993 • 147 citations

Second messenger systems and psychoactive drug action: focus on the phosphoinositide system and lithium

1989 • 142 citations

Abnormal intracellular calcium ion concentration in platelets and lymphocytes of bipolar patients

1992 • 139 citations

Hyperfunctional G proteins in mononuclear leukocytes of patients with mania

1991 • 132 citations

Postmortem cerebral cortex Gs α-subunit levels are elevated in bipolar affective disorder

1991 • 126 citations

Phosphorus-31 magnetic resonance spectroscopy and ventricular enlargement in bipolar disorder

1994 • 124 citations

Decreased temporal lobe phosphomonoesters in bipolar disorder

1995 • 119 citations

Lateralized abnormality of high energy phosphate metabolism in the frontal lobes of patients with bipolar disorder detected by phase-encoded³¹P-MRS

1995 • 114 citations

Elevated platelet intracellular calcium concentration in bipolar depression

1991 • 107 citations

The involvement of guanine nucleotide binding proteins in the pathogenesis and treatment of affective disorders

1992 • 105 citations

Intracellular calcium signalling in peripheral cells of patients with bipolar affective disorder

1994 • 97 citations

Measurement of brain phosphoinositide metabolism in bipolar patients using in vivo 31P-MRS

1991 • 95 citations

Mononuclear leukocyte levels of G proteins in depressed patients with bipolar disorder or major depressive disorder

1994 • 93 citations

Guanine Nucleotide-Binding Proteins in Bipolar Affective Disorder

1995 • 84 citations

Lithium and the brain: a psychopharmacological strategy to a molecular basis for manic depressive illness

1994 • 80 citations

Serotonin-induced platelet calcium mobilization is enhanced in mania

1994 • 69 citations

Elevated platelet membrane phosphatidylinositol-4,5-bisphosphate in bipolar mania

1993 • 68 citations

The calcium second messenger system in bipolar disorders: data supporting new research directions

1992 • 66 citations

Thrombin-induced platelet calcium mobilization is enhanced in bipolar disorders

1992 • 62 citations

Dysbalance of neuronal second messenger function in the aetiology of affective disorders: A pathophysiological concept hypothesising defects beyond first messenger receptors

1989 • 55 citations

Abnormal signal transduction: A hypothetical model for bipolar affective disorder

1989 • 54 citations

The platelet intracellular calcium response to serotonin is augmented in bipolar manic and depressed patients

1995 • 47 citations

Analysis of complex mixtures of phospholipid classes from cell membranes using two-dimensional thin-layer chromatography and scanning laser densitometry

1993 • 46 citations

The Second-Messenger Dysbalance Hypothesis of Affective Disorders

1990 • 45 citations

Dopamine increases platelet intracellular calcium in bipolar affective disorder and controls

1994 • 29 citations

Second Messengers and Affective Illness

1992 • 15 citations

Deleted Work

1955 • 0 citations