Dysbalance of neuronal second messenger function in the aetiology of affective disorders: A pathophysiological concept hypothesising defects beyond first messenger receptors

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

THE CATECHOLAMINE HYPOTHESIS OF AFFECTIVE DISORDERS: A REVIEW OF SUPPORTING EVIDENCE

1965 • 3,421 citations

Phosphorylation-Dephosphorylation of Enzymes

1979 • 2,205 citations

The Biochemistry of Affective Disorders

1967 • 1,183 citations

The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain.

1980 • 1,099 citations

A CHOLINERGIC-ADRENERGIC HYPOTHESIS OF MANIA AND DEPRESSION

1972 • 1,077 citations

Action of various antidepressant treatments reduces reactivity of noradrenergic cyclic AMP-generating system in limbic forebrain

1975 • 599 citations

Tissue-specific expression of three distinct types of rabbit protein kinase C

1987 • 469 citations

Antidepressants and the Muscarinic Acetylcholine Receptor

1977 • 429 citations

Mechanism by which psychotropic drugs inhibit adenosine cyclic 3',5'-monophosphate phosphodiesterase of brain.

1976 • 389 citations

Potential antidepressant activity of rolipram and other selective cyclic adenosine 3′,5′-monophosphate phosphodiesterase inhibitors

1983 • 239 citations

Results of a Phase II Study of the Antidepressant Effect of Rolipram

1984 • 175 citations

Problems with current catecholamine hypotheses of antidepressant agents: Speculations leading to a new hypothesis

1983 • 163 citations

3',5' CYCLIC ADENOSINE MONOPHOSPHATE IN DEPRESSION AND MANIA

1970 • 154 citations

Effects of lithium in vitro and ex vivo on components of the adenylate cyclase system in membranes from the cerebral cortex of the rat

1987 • 144 citations

Guanosine Triphosphate Activation of Brain Adenylate Cyclase: Enhancement by Long-Term Antidepressant Treatment

1983 • 142 citations

Beta-adrenergic receptor function in affective illness

1979 • 130 citations

Cholinomimetic and anticholinergic drugs used to investigate an acetylcholine hypothesis of affective disorders and stress

1984 • 126 citations

Changes in lymphocyte beta-adrenergic receptors in depression and mania

1979 • 117 citations

Animal Models in Psychiatric Research

1986 • 80 citations

Mode of Action of Lithium on the Catalytic Unit of Adenylate Cyclase from Rat Brain

1987 • 71 citations

LITHIUM AND BRAIN ADENYL CYCLASE

1970 • 68 citations

The Anticholinergic Biperiden in Depressive Disorders

1981 • 68 citations

Lithium at therapeutic concentrations inhibits human brain noradrenaline-sensitive cyclic AMP accumulation

1983 • 51 citations

Possible receptor effects of chronic lithium administration

1983 • 50 citations

Mechanisms in the vectorial receptor-adenylate cyclase signal transduction.

1984 • 41 citations

General properties of multiple molecular forms of cyclic nucleotide phosphodiesterase in the nervous system.

1984 • 39 citations

Effects of forskolin and cyclic nucleotides in animal models predictive of antidepressant activity: interactions with rolipram

1986 • 35 citations

The cyclic AMP second messenger system in man: The effects of heredity, hormones, drugs, aluminum, age and disease on signal amplification

1986 • 35 citations

Affective and atopic disorders and cyclic AMP

1976 • 32 citations

Antidepressant properties of some phosphodiesterase inhibitors.

1983 • 26 citations

Lithium versus Placebo in Acute Depression: a Clinical Trial

1987 • 23 citations

The ability of antidepressant drugs to desensitize β-receptors is inversely correlated with their clinical potency

1984 • 23 citations

Fluoride-stimulated adenylate cyclase activity in rat brain following chronic treatment with psychotropic drugs

1984 • 22 citations

Deamplification of noradrenergic signal transfer by antidepressants: a unified catecholamine-serotonin hypothesis of affective disorders.

1983 • 22 citations

Selective interaction of tricyclic antidepressants with a subclass of rat brain cholinergic muscarinic receptors

1987 • 18 citations

Differential effects of chronic administration of desipramine on the cyclic AMP response in cortical slices and membranes in the rat

1987 • 17 citations

[Preliminary results of a double-blind study between rolipram and desipramine in hospitalized patients with major depressive symptoms].

1987 • 7 citations

Deleted Work

1955 • 0 citations