Innate Immune Responses to Transplants

In search of the ‘missing self’: MHC molecules and NK cell recognition

1990 • 2,600 citations

NATURAL KILLER CELLS IN ANTIVIRAL DEFENSE: Function and Regulation by Innate Cytokines

1999 • 2,128 citations

Soluble Human Complement Receptor Type 1: In Vivo Inhibitor of Complement Suppressing Post-Ischemic Myocardial Inflammation and Necrosis

1990 • 989 citations

Function of C-reactive protein

2000 • 743 citations

Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity

2000 • 669 citations

Activated platelets signal chemokine synthesis by human monocytes.

1996 • 598 citations

P-selectin induces the expression of tissue factor on monocytes.

1994 • 595 citations

C-Reactive Protein and Complement Are Important Mediators of Tissue Damage in Acute Myocardial Infarction

1999 • 506 citations

The cytokine-adhesion molecule cascade in ischemia/reperfusion injury of the rat kidney. Inhibition by a soluble P-selectin ligand.

1997 • 503 citations

C5a-induced expression of P-selectin in endothelial cells.

1994 • 470 citations

Alpha and beta chemokines induce NK cell migration and enhance NK-mediated cytolysis.

1995 • 459 citations

Complement Proteins C5b-9 Induce Secretion of High Molecular Weight Multimers of Endothelial von Willebrand Factor and Translocation of Granule Membrane Protein GMP-140 to the Cell Surface

1989 • 442 citations

Reperfusion injury of ischemic skeletal muscle is mediated by natural antibody and complement.

1996 • 378 citations

Natural cytotoxicity receptors that trigger human NK-cell-mediated cytolysis

2000 • 358 citations

Complement Activation after Oxidative Stress

2000 • 332 citations

The Cytolytically Inactive Terminal Complement Complex Activates Endothelial Cells to Express Adhesion Molecules and Tissue Factor Procoagulant Activity

1997 • 318 citations

The long pentraxin PTX3 binds to apoptotic cells and regulates their clearance by antigen-presenting dendritic cells

2000 • 306 citations

Pharmacology and Biological Efficacy of a Recombinant, Humanized, Single-Chain Antibody C5 Complement Inhibitor in Patients Undergoing Coronary Artery Bypass Graft Surgery With Cardiopulmonary Bypass

1999 • 289 citations

Follow the leader

1992 • 280 citations

Activation of intragraft endothelial and mononuclear cells during discordant xenograft rejection.

1994 • 264 citations

Terminal complement proteins C5b-9 release basic fibroblast growth factor and platelet-derived growth factor from endothelial cells.

1994 • 263 citations

CRP-mediated activation of complement in vivo: assessment by measuring circulating complement-C-reactive protein complexes.

1996 • 233 citations

Deficiency of a leukocyte surface glycoprotein (LFA-1) in two patients with Mo1 deficiency. Effects of cell activation on Mo1/LFA-1 surface expression in normal and deficient leukocytes.

1984 • 224 citations

ACTIVATION OF INTRAGRAFT ENDOTHELIAL AND MONONUCLEAR CELLS DURING DISCORDANT XENOGRAFT REJECTION

1994 • 223 citations

Heat shock protein 70 (Hsp70) stimulates proliferation and cytolytic activity of natural killer cells

1999 • 219 citations

Activation of the Heart by Donor Brain Death Accelerates Acute Rejection After Transplantation

2000 • 205 citations

Human T Cells Express the C5a Receptor and Are Chemoattracted to C5a

1999 • 203 citations

Fractalkine-Mediated Endothelial Cell Injury by NK Cells

2000 • 194 citations

The control of homologous lysis

1991 • 190 citations

Interleukin 2 mediates stimulation of complement C3 biosynthesis in human proximal tubular epithelial cells.

1991 • 184 citations

Human NK-cell receptors

2000 • 176 citations

The response of human platelets to activated components of the complement system

1991 • 175 citations

The membrane attack complex of complement induces interleukin-8 and monocyte chemoattractant protein-1 secretion from human umbilical vein endothelial cells.

1996 • 161 citations

A Comparison of C3a and C5a-Mediated Stable Adhesion of Rolling Eosinophils in Postcapillary Venules and Transendothelial Migration In Vitro and In Vivo

1999 • 158 citations

Follow the Leader: NK Cell Receptors for Classical and Nonclassical MHC Class I

1998 • 156 citations

Induction of interleukin-8 synthesis from monocytes by human C5a anaphylatoxin.

1994 • 144 citations

CD11a-c/CD18 and GP84 (LB-2) adhesion molecules on human large granular lymphocytes and their participation in natural killing.

1988 • 143 citations

Early Local Generation of C5a Initiates the Elicitation of Contact Sensitivity by Leading to Early T Cell Recruitment

2000 • 116 citations

COMPLEMENT DEPOSITION IN EARLY CARDIAC TRANSPLANT BIOPSIES IS ASSOCIATED WITH ISCHEMIC INJURY AND SUBSEQUENT REJECTION EPISODES1

1999 • 116 citations

CD28-B7 blockade in organ dysfunction secondary to cold ischemia/reperfusion injury: Rapid Communication

1997 • 106 citations

Natural killer cells and their role in graft rejection

1998 • 90 citations

Expression of granzyme A and B proteins by cytotoxic lymphocytes involved in acute renal allograft rejection

1995 • 90 citations

Complement-Dependent Acute-Phase Expression of C-Reactive Protein and Serum Amyloid P-Component

2000 • 88 citations

Vigorous Allograft Rejection in the Absence of Danger

2000 • 81 citations

Are “natural killer” cells involved in allograft rejection?

1983 • 80 citations

Living unrelated renal donation: The University of Wisconsin experience

1998 • 78 citations

In Situ Localization of C3 Synthesis in Experimental Acute Renal Allograft Rejection

2000 • 75 citations

Natural killer cells: Endothelial interactions, migration, and target cell recognition

1997 • 75 citations

Local T cell responses induce widespread MHC expression. Evidence that IFN-gamma induces its own expression in remote sites.

1992 • 72 citations

Oxidized-LDL Induce the Expression of Heat Shock Protein 70 in Human Endothelial Cells

1994 • 62 citations

EARLY INCREASED CHEMOKINE EXPRESSION AND PRODUCTION IN MURINE ALLOGENEIC SKIN GRAFTS IS MEDIATED BY NATURAL KILLER CELLS1

2000 • 57 citations

C6 Produced by Macrophages Contributes to Cardiac Allograft Rejection

1999 • 56 citations

MHC CLASS II EXPRESSION ON HUMAN HEART MICROVASCULAR ENDOTHELIAL CELLS

1997 • 55 citations

Pretransplantation hemodialysis strategy influences early renal graft function.

1998 • 52 citations

Lack of evidence for an active role for natural killer cells in acute rejection of organ allografts.

1985 • 48 citations

IMPORTANCE OF NATURAL KILLER CELLS IN THE REJECTION OF HAMSTER SKIN XENOGRAFTS

1998 • 43 citations

LACK OF EVIDENCE FOR AN ACTIVE ROLE FOR NATURAL KILLER CELLS IN ACUTE REJECTION OF ORGAN ALLOGRAFTS

1985 • 43 citations

Induction of transporter associated with antigen processing by interferon γ confers endothelial cell cytoprotection against natural killer-mediated lysis

1998 • 41 citations

Allogeneic Heart Transplantation Activates Alloreactive NK Cells

1997 • 41 citations

Contact-dependent endothelial class II HLA gene activation induced by NK cells is mediated by IFN-gamma-dependent and -independent mechanisms.

1995 • 40 citations

Class II transactivator-independent endothelial cell MHC class II gene activation induced by lymphocyte adhesion.

1998 • 34 citations

SERUM C-REACTIVE PROTEIN

1996 • 34 citations

Characterization and molecular cloning of rat C1qRp, a receptor on NK cells

2000 • 30 citations

Mannan-binding lectin and C1q bind to distinct structures and exert differential effects on macrophages

2000 • 27 citations

Cutting Edge: Class II Transactivator-Independent Endothelial Cell MHC Class II Gene Activation Induced by Lymphocyte Adhesion

1998 • 25 citations

Effect of selective depletion of natural killer cells on allograft rejection.

1991 • 17 citations

EVIDENCE THAT EARLY ACUTE RENAL FAILURE MAY BE MEDIATED BY CD3- CD16+ CELLS IN A KIDNEY GRAFT RECIPIENT WITH LARGE GRANULAR LYMPHOCYTE PROLIFERATION

1992 • 17 citations

Enhancement Of NK Cell-Mediated Antibody-Dependent Lysis Of Recombinant gp120-Coated CD4 Cells By Complement

1995 • 17 citations

Effect of selective depletion of natural killer cells on allograft rejection.

1991 • 16 citations