Functional control of regulatory T cells and cancer immunotherapy

Toll-like receptor signalling

2004 • 7,983 citations

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

2004 • 4,872 citations

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

Toll-like receptor control of the adaptive immune responses

2004 • 4,092 citations

Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8

2004 • 3,766 citations

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA

2004 • 3,325 citations

N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

Toll-like receptors in innate immunity

2004 • 3,233 citations

Tolerogenic Dendritic Cells

2003 • 3,131 citations

An essential role for Scurfin in CD4+CD25+ T regulatory cells

2003 • 2,825 citations

The Three Es of Cancer Immunoediting

2004 • 2,781 citations

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

2005 • 2,667 citations

Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway

2002 • 2,438 citations

Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3

2005 • 2,256 citations

CD4+CD25+ suppressor T cells: more questions than answers

2002 • 2,202 citations

IRF-7 is the master regulator of type-I interferon-dependent immune responses

2005 • 2,108 citations

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

2000 • 2,090 citations

Toll Pathway-Dependent Blockade of CD4 ⁺ CD25 ⁺ T Cell-Mediated Suppression by Dendritic Cells

2003 • 2,023 citations

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

Recognition of single-stranded RNA viruses by Toll-like receptor 7

2004 • 1,777 citations

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

2001 • 1,659 citations

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.

1998 • 1,579 citations

Induction of Interleukin 10–Producing, Nonproliferating Cd4+ T Cells with Regulatory Properties by Repetitive Stimulation with Allogeneic Immature Human Dendritic Cells

2000 • 1,577 citations

Immunologic tolerance maintained by CD25⁺ CD4⁺ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance

2001 • 1,515 citations

Prevalence of Regulatory T Cells Is Increased in Peripheral Blood and Tumor Microenvironment of Patients with Pancreas or Breast Adenocarcinoma

2002 • 1,454 citations

Progress in human tumour immunology and immunotherapy

2001 • 1,327 citations

Modulation of tryptophan catabolism by regulatory T cells

2003 • 1,323 citations

Regulatory T cells in transplantation tolerance

2003 • 1,323 citations

Regulatory T Cells in Autoimmmunity

2000 • 1,267 citations

Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25– T cells

2003 • 1,252 citations

Regulatory T cells in the control of immune pathology

2001 • 1,197 citations

In Vitro–expanded Antigen-specific Regulatory T Cells Suppress Autoimmune Diabetes

2004 • 1,192 citations

Homeostatic maintenance of natural Foxp3+ CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

2005 • 1,189 citations

Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer.

2001 • 1,126 citations

Potential Regulatory Function of Human Dendritic Cells Expressing Indoleamine 2,3-Dioxygenase

2002 • 1,035 citations

Synergism of Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Depletion of Cd25+ Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic T Lymphocyte Responses

2001 • 1,033 citations

Mechanisms of suppression by suppressor T cells

2005 • 1,023 citations

Identification of a putative second T-cell receptor

1986 • 980 citations

Regulatory T Cells Selectively Express Toll-like Receptors and Are Activated by Lipopolysaccharide

2003 • 976 citations

Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors

2005 • 973 citations

TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells

2005 • 955 citations

Direct Expansion of Functional CD25+ CD4+ Regulatory T Cells by Antigen-processing Dendritic Cells

2003 • 893 citations

Spatiotemporal regulation of MyD88–IRF-7 signalling for robust type-I interferon induction

2005 • 886 citations

Induction and mechanism of action of transforming growth factor‐β‐secreting Th3 regulatory cells

2001 • 856 citations

Origin of regulatory T cells with known specificity for antigen

2002 • 854 citations

Regulatory T cells and mechanisms of immune system control

2004 • 809 citations

CD25+ CD4+ T Cells, Expanded with Dendritic Cells Presenting a Single Autoantigenic Peptide, Suppress Autoimmune Diabetes

2004 • 741 citations

Toll-Like Receptor 8-Mediated Reversal of CD4 ⁺ Regulatory T Cell Function

2005 • 734 citations

In Vivo Instruction of Suppressor Commitment in Naive T Cells

2004 • 726 citations

Class I–restricted Cross-Presentation of Exogenous Self-Antigens Leads to Deletion of Autoreactive CD8+ T Cells

1997 • 719 citations

Recognition of the Peripheral Self by Naturally Arising CD25+ CD4+ T Cell Receptors

2004 • 690 citations

Foxp3 Expressing CD4+CD25high Regulatory T Cells Are Overrepresented in Human Metastatic Melanoma Lymph Nodes and Inhibit the Function of Infiltrating T Cells

2004 • 680 citations

Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells

2003 • 674 citations

Professional Antigen-Presentation Function by Human γδ T Cells

2005 • 668 citations

Natural and Induced CD4+CD25+ Cells Educate CD4+CD25− Cells to Develop Suppressive Activity: The Role of IL-2, TGF-β, and IL-10

2004 • 657 citations

Cyclophosphamide-facilitated adoptive immunotherapy of an established tumor depends on elimination of tumor-induced suppressor T cells.

1982 • 640 citations

Infectious Tolerance

2002 • 614 citations

Antigen-dependent Proliferation of CD4+ CD25+ Regulatory T Cells In Vivo

2003 • 600 citations

Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter

2005 • 583 citations

Flexibility of Mouse Classical and Plasmacytoid-derived Dendritic Cells in Directing T Helper Type 1 and 2 Cell Development

2003 • 561 citations

Concomitant Tumor Immunity to a Poorly Immunogenic Melanoma Is Prevented by Regulatory T Cells

2004 • 541 citations

Tumor-Specific Human CD4+ Regulatory T Cells and Their Ligands

2004 • 525 citations

Continuous Activation of Autoreactive CD4+ CD25+ Regulatory T Cells in the Steady State

2003 • 523 citations

Human CD4+CD25+ Regulatory, Contact-dependent T Cells Induce Interleukin 10–producing, Contact-independent Type 1-like Regulatory T Cells

2002 • 484 citations

Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency

1998 • 447 citations

Human CD25+CD4+ T Suppressor Cell Clones Produce Transforming Growth Factor β, but not Interleukin 10, and Are Distinct from Type 1 T Regulatory Cells

2002 • 440 citations

Regulatory T cells under scrutiny

2003 • 427 citations

TGF-β regulatesin vivoexpansion of Foxp3-expressing CD4⁺CD25⁺regulatory T cells responsible for protection against diabetes

2004 • 425 citations

The Role of IL-10 and TGF-β in the Differentiation and Effector Function of T Regulatory Cells

2002 • 408 citations

Induction of CD4+/CD25+ regulatory T cells by targeting of antigens to immature dendritic cells

2003 • 392 citations

In vivodynamics of antigen-specific regulatory T cells not predicted from behaviorin vitro

2003 • 384 citations

T-cell-mediated suppression of anti-tumor immunity. An explanation for progressive growth of an immunogenic tumor.

1980 • 373 citations

Reversal of Tumor-induced Dendritic Cell Paralysis by CpG Immunostimulatory Oligonucleotide and Anti–Interleukin 10 Receptor Antibody

2002 • 340 citations

Analysis of regulatory CD8 T cells in Qa-1-deficient mice

2004 • 330 citations

The role of different subsets of T regulatory cells in controlling autoimmunity

2000 • 323 citations

Inducible Transgenic Mice Reveal Resting Dendritic Cells as Potent Inducers of CD8+ T Cell Tolerance

2003 • 309 citations

Human tumor antigens for cancer vaccine development

1999 • 298 citations

CD40 Ligation Releases Immature Dendritic Cells from the Control of Regulatory CD4+CD25+ T Cells

2003 • 292 citations

Suppressor T cells – they’re back and critical for regulation of autoimmunity!

2001 • 289 citations

Peripheral Autoantigen Induces Regulatory T Cells that Prevent Autoimmunity

1999 • 284 citations

Conversion of CD4+ CD25− cells into CD4+ CD25+ regulatory T cells in vivo requires B7 costimulation, but not the thymus

2005 • 271 citations

Specificity requirements for selection and effector functions of CD25⁺4⁺regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice

2002 • 267 citations

Role for IL-10 in Suppression Mediated by Peptide-Induced Regulatory T Cells In Vivo

2003 • 252 citations

An integrated view of suppressor T cell subsets in immunoregulation

2004 • 248 citations

Dendritic Cells in Immunity and Tolerance—Do They Display Opposite Functions?

2003 • 237 citations

CD4+ regulatory T cells in autoimmunity and allergy

2002 • 236 citations

Natural regulatory T cells and self-tolerance

2005 • 234 citations

CD4+ CD25+ Regulatory T Cells Control T Helper Cell Type 1 Responses to Foreign Antigens Induced by Mature Dendritic Cells In Vivo

2003 • 230 citations

Control of Foxp3+ CD25+CD4+ regulatory cell activation and function by dendritic cells

2004 • 226 citations

Depletion of CD4+CD25+ Regulatory Cells Augments the Generation of Specific Immune T Cells in Tumor-Draining Lymph Nodes

2002 • 206 citations

Regulatory T Cell Suppression and Anergy Are Differentially Regulated by Proinflammatory Cytokines Produced by TLR-Activated Dendritic Cells

2004 • 202 citations

Immunity against cancer: lessons learned from melanoma

2001 • 190 citations

Antigen Recognition Determinants of γδ T Cell Receptors

2005 • 178 citations

Cutting Edge: Self-Peptides Drive the Peripheral Expansion of CD4+CD25+ Regulatory T Cells

2003 • 177 citations

The inhibitory function of B7 costimulators in T cell responses to foreign and self-antigens

2003 • 177 citations

CD4⁺CD25⁺T cells responding to serologically defined autoantigens suppress antitumor immune responses

2003 • 168 citations

The Specific Regulation Of Immune Responses By CD8⁺T Cells Restricted By The MHC Class Ib Molecule, Qa-1

2000 • 168 citations

Experimental autoimmune prostatitis after neonatal thymectomy in the mouse.

1985 • 161 citations

Recognition of a New ARTC1 Peptide Ligand Uniquely Expressed in Tumor Cells by Antigen-Specific CD4+ Regulatory T Cells

2005 • 156 citations

Costimulation controls diabetes by altering the balance of pathogenic and regulatory T cells

2004 • 150 citations

License to Heal: Bidirectional Interaction of Antigen-Specific Regulatory T Cells and Tolerogenic APC

2005 • 147 citations

Depletion of IL-10- and TGF-beta-producing regulatory gamma delta T cells by administering a daunomycin-conjugated specific monoclonal antibody in early tumor lesions augments the activity of CTLs and NK cells.

1999 • 144 citations

Qa-1 restriction of CD8+ suppressor T cells

2004 • 142 citations

Costimulation controls diabetes by altering the balance of pathogenic and regulatory T cells

2004 • 141 citations

Definition of target antigens for naturally occurring CD4+ CD25+ regulatory T cells

2005 • 131 citations

Clonal analysis of cytotoxic and regulatory T cell responses against human melanoma.

1989 • 130 citations

Progress on new vaccine strategies against chronic viral infections

2004 • 124 citations

Depletion of IL-10- and TGF-β-Producing Regulatory γδ T Cells by Administering a Daunomycin-Conjugated Specific Monoclonal Antibody in Early Tumor Lesions Augments the Activity of CTLs and NK Cells

1999 • 123 citations

Immunologically mediated regression of a murine lymphoma after treatment with anti-L3T4 antibody. A consequence of removing L3T4+ suppressor T cells from a host generating predominantly Lyt-2+ T cell-mediated immunity.

1988 • 118 citations

Role of dendritic cells in the generation of regulatory T cells

2004 • 105 citations

Progress on new vaccine strategies against chronic viral infections

2004 • 101 citations

?-Irradiation facilitates the expression of adoptive immunity against established tumors by eliminating suppressor T cells

1984 • 92 citations

Functional Characterization of EBV-Encoded Nuclear Antigen 1–Specific CD4+ Helper and Regulatory T Cells Elicited byIn vitroPeptide Stimulation

2005 • 88 citations

CD4+ CD25+ Regulatory T Cell Repertoire Formation in Response to Varying Expression of a neo-Self-Antigen

2004 • 76 citations

Inducible costimulator-dependent IL-10 production by regulatory T cells specific for self-antigen

2004 • 75 citations

Autologous melanoma-induced activation of regulatory T cells that suppress cytotoxic response.

1990 • 75 citations

Elimination of cycling CD4+ suppressor T cells with an anti-mitotic drug releases non-cycling CD8+ T cells to cause regression of an advanced lymphoma.

1990 • 71 citations

γδ T cells: A new frontier for immunotherapy?

2005 • 69 citations

Enhancing antitumor immune responses: intracellular peptide delivery and identification of MHC class II‐restricted tumor antigens

2002 • 49 citations

The Significance of Immune Suppression in Normal Self Tolerance

1996 • 32 citations

Interception of the development of self tolerance in fetal lambs

1989 • 32 citations

Reviving suppression?

2004 • 21 citations

T cell suppression as an obstacle to immunologically-mediated tumor regression: elimination of suppression results in regression.

1987 • 16 citations