Molecular Biology of the H-2 Histocompatibility Complex

DNA Methylation and Gene Function

1980 • 2,069 citations

MHC-Restricted Cytotoxic T Cells: Studies on the Biological Role of Polymorphic Major Transplantation Antigens Determining T-Cell Restriction-Specificity, Function, and Responsiveness

1979 • 1,969 citations

Binding of immunogenic peptides to Ia histocompatibility molecules

1985 • 1,209 citations

Biology of the Mouse Histocompatibility-2 Complex

1975 • 1,145 citations

Role of MHC Gene Products in Immune Regulation

1981 • 705 citations

T Cell Subsets and the Recognition of MHC Class

1983 • 702 citations

The class II molecules of the human and murine major histocompatibility complex

1984 • 664 citations

Inducible expression of H–2 and Ia antigens on brain cells

1984 • 656 citations

Antigen presentation: comments on its regulation and mechanism.

1984 • 498 citations

Lymphocytes recognize human vascular endothelial and dermal fibroblast Ia antigens induced by recombinant immune interferon

1983 • 487 citations

A molecular map of the immune response region from the major histocompatibility complex of the mouse

1982 • 466 citations

T cell antigen receptors and the immunoglobulin supergene family

1985 • 453 citations

Genes of the Major Histocompatibility Complex of the Mouse

1983 • 445 citations

Increased expression of Ia antigens on resting B cells: an additional role for B-cell growth factor.

1984 • 438 citations

Clusters of genes encoding mouse transplantation antigens

1982 • 419 citations

SERUM-FERRITIN

1974 • 336 citations

The traditional and a new version of the mouse H–2 complex

1981 • 325 citations

Organization and evolution of the class I gene family in the major histocompatibility complex of the C57BL/10 mouse

1984 • 323 citations

ANTIGENIC MODULATION

1968 • 322 citations

A pseudogene homologous to mouse transplantation antigens: Transplantation antigens are encoded by eight exons that correlate with protein domains

1981 • 320 citations

Gene organization and recombinational hotspots in the murine major histocompatibility complex

1986 • 312 citations

Interleukin-induced increase in Ia expression by normal mouse B cells.

1984 • 293 citations

Murine Major Histocompatibility Complex Class-I Mutants: Molecular Analysis and Structure-Function Implications

1986 • 286 citations

H-2 haplotypes, genes, and antigens: Second listing

1982 • 283 citations

The DNA sequence of the H-2kb gene: evidence for gene conversion as a mechanism for the generation of polymorphism in histocompatibilty antigens.

1983 • 280 citations

The structure of a mutant H–2 gene suggests that the generation of polymorphism in H–2 genes may occur by gene conversion-like events

1983 • 277 citations

Genetic Complexity and Expression of Human Class II Histocompatibility Antigens

1985 • 247 citations

Exon shuffling: mapping polymorphic determinants on hybrid mouse transplantation antigens

1982 • 229 citations

Antigenic Properties of Experimental Leukemias. I. Serological Studies <italic>In Vitro</italic> With Spontaneous and Radiation-Induced Leuke-mias<xref ref-type="fn" rid="FN2">2</xref>

1963 • 225 citations

Domain interactions of H–2 class I antigens alter cytotoxic T-cell recognition sites

1984 • 207 citations

Primary structure of a murine transplantation antigen

1981 • 194 citations

Spontaneous H-2 mutants provide evidence that a copy mechanism analogous to gene conversion generates polymorphism in the major histocompatibility complex.

1983 • 188 citations

Mouse major histocompatibility class I gene expression begins at midsomite stage and is inducible in earlier-stage embryos by interferon.

1985 • 185 citations

Immunoprecipitation of cell surface structures of cloned cytotoxic T lymphocytes by clone-specific antisera.

1984 • 183 citations

Nucleotide sequence of mutant I-Aβbm12 gene is evidence for genetic exchange between mouse immune response genes

1984 • 178 citations

Increased expression of I-region-associated antigen (Ia) on B cells after cross-linking of surface immunoglobulin.

1981 • 176 citations

IMMUNOGENETICS OF CELL SURFACE ANTIGENS OF MOUSE LEUKEMIA

1977 • 174 citations

Correcting an immune-response deficiency by creating Eα gene transgenic mice

1985 • 171 citations

Variable synthesis and expression of E β and A e (E β ) Ia polypeptide chains in mice of differentH-2 haplotypes

1981 • 165 citations

Histocompatibility Antigens on Murine Tumors

1985 • 164 citations

Cell type-specific enhancer element associated with a mouse MHC gene, Eβ

1984 • 162 citations

Activation of a Qa/Tla class I major histocompatibility antigen gene is a general feature of oncogenesis in the mouse

1983 • 161 citations

Identification of the class I genes of the mouse major histocompatibility complex by DNA-mediated gene transfer

1982 • 156 citations

Secretion of a transplantation-related antigen

1983 • 150 citations

A nonpolymorphic class I gene in the murine major histocompatibility complex

1984 • 146 citations

Genetic mapping in the major histocompatibility complex by restriction enzyme site polymorphisms: most mouse class I genes map to the Tla complex.

1983 • 136 citations

A potential donor gene for the bm1 gene conversion event in the C57BL mouse

1983 • 134 citations

Inhibition of antigen-specific T lymphocyte activation by structurally related Ir gene-controlled polymers. Evidence of specific competition for accessory cell antigen presentation.

1983 • 132 citations

The nucleotide sequence of the murine I-E beta b immune response gene: evidence for gene conversion events in class II genes of the major histocompatibility complex.

1984 • 131 citations

Ontogeny of Ia and IgD on IgM-bearing B lymphocytes in mice.

1977 • 129 citations

Major Histocompatibility Complex Restricted Cell-Mediated Immunity

1978 • 126 citations

Functional expression of a microinjected Edα gene in C57BL/6 transgenic mice

1985 • 126 citations

Gene conversion between murine class II major histocompatibility complex loci. Functional and molecular evidence from the bm 12 mutant.

1984 • 126 citations

Ia Antigens as Restriction Molecules in Ir-Gene Controlled T-Cell Proliferation

1983 • 124 citations

Chemically related antigens compete for presentation by accessory cells to T cells.

1982 • 121 citations

Comparison of the cloned H-2Kbm1 variant gene with the H-2Kb gene shows a cluster of seven nucleotide differences.

1983 • 120 citations

Organization and evolution of D region class I genes in the mouse major histocompatibility complex.

1986 • 116 citations

Developmental activation of the H-2K gene is correlated with an increase in DNA methylation

1983 • 115 citations

Differential regulation of HLA-DR mRNAs and cell surface antigens by interferon.

1983 • 112 citations

Structure of a gene encoding a murine thymus leukemia antigen, and organization of Tla genes in the BALB/c mouse.

1985 • 111 citations

Duplicated gene pairs and alleles of class I genes in the Qa2 region of the murine major histocompatibility complex: a comparison.

1985 • 107 citations

Expression and function of transplantation antigens with altered or deleted cytoplasmic domains

1983 • 105 citations

Hybrid H-2 histocompatibility gene products assign domains recognized by alloreactive T cells.

1983 • 104 citations

Tissue-specific expression of an unusual H-2 (class I)-related gene.

1982 • 101 citations

IA mutant functional antigen-presenting cell lines.

1983 • 100 citations

"Exon-shuffling" maps control of antibody- and T-cell-recognition sites to the NH2-terminal domain of the class II major histocompatibility polypeptide A beta.

1985 • 98 citations

Analysis of the Expression and Function of Class-II Major Histocompatibility Complex-Encoded Molecules by DNA-Mediated Gene Transfer

1986 • 96 citations

Expression of class I genes in the major histocompatibility complex: identification of eight distinct mRNAs in DBA/2 mouse liver

1985 • 95 citations

Allospecific and virus-specific cytolytic T lymphocytes are restricted to the N or C1 domain of H-2 antigens expressed on L cells after DNA-mediated gene transfer.

1983 • 92 citations

Structure and expression of genes encoding murine Qa-2 class I antigens.

1985 • 86 citations

Isolation of a cDNA clone for the murine transplantation antigen H-2Kb.

1982 • 86 citations

Construction, expression and recognition of an H—2 molecule lacking its carboxyl terminus

1984 • 84 citations

Cytolytic T cells recognize the two amino-terminal domains of H-2 K antigens in tandem in influenza A infected cells

1984 • 82 citations

Detection of a secreted form of the murine H-2 class I antigen with an antibody against its predicted carboxyl terminus.

1984 • 76 citations

Endogenously produced Ia antigens within cells of convoluted tubules of rat kidney.

1981 • 75 citations

ANTIGENIC MODULATION IN VITRO

1974 • 75 citations

Level of mIa expression on mitogen-stimulated murine B lymphocytes is dependent on position in cell cycle.

1983 • 75 citations

Tissue-specific, inducible and functional expression of the E alpha d MHC class II gene in transgenic mice.

1985 • 70 citations

Alternative RNA splicing in expression of the H–2Kgene

1983 • 64 citations

Structure and Polymorphism of Murine and Human Class II Major Histocompatibility Antigens

1985 • 62 citations

Dissection of serological and cytolytic T lymphocyte epitopes on murine major histocompatibility antigens by a recombinant H-2 gene separating the first two external domains.

1984 • 62 citations

Structural analysis of TL genes of the mouse.

1985 • 61 citations

Sequence of gene and cDNA encoding murine major histocompatibility complex class II gene A beta 2.

1985 • 60 citations

Regulated expression of an introduced MHC H–2Kbm1 gene in murine embryonal carcinoma cells

1984 • 57 citations

Interaction between Kb and Q4 gene sequences generates the Kbm6 mutation.

1986 • 56 citations

T-cell recognition of a chimaeric class II/class I MHC molecule and the role of L3T4

1985 • 55 citations

Secretion of a soluble class I molecule encoded by the Q10 gene of the C57BL/10 mouse.

1985 • 54 citations

Mouse histocompatibility-related genes are not conserved in other mammals.

1985 • 54 citations

A class II gene conversion event defines an antigen-specific Ir gene epitope.

1984 • 49 citations

Conservation and diversity in the class I genes of the major histocompatibility complex: sequence analysis of a Tlab gene and comparison with a Tlac gene.

1986 • 47 citations

Thymus-leukemia (TL) antigens of the mouse. Analysis of TL mRNA and TL cDNA TL+ and TL- strains.

1985 • 47 citations

Lyb Antigens and their Role in B Lymphocyte Activation

1983 • 47 citations

The I region of the C57BL/10 mouse: characterization and physical linkage to H-2K of an SB beta-like class II pseudogene, psi A beta 3.

1985 • 47 citations

Organization and Expression of the MHC of the C57 Black/10 Mouse

1985 • 47 citations

Multiple mechanisms regulate the expression of murine immune response genes

1985 • 46 citations

A directional process of gene conversion is expected to yield dynamic polymorphism associated with stability of alternative alleles in class I histocompatibility antigens gene family

1983 • 41 citations

Expression and T cell recognition of hybrid antigens with amino-terminal domains encoded by Qa-2 region of major histocompatibility complex and carboxyl termini of transplantation antigens.

1985 • 41 citations

A major rearrangement in the H–2 complex of mouse t haplotypes

1983 • 39 citations

Alternative splicing in the 5′ moiety of the H-2Kd gene transcript.

1984 • 38 citations

Cytotoxic T lymphocytes recognize determinants on the BALB/c-H-2Ld molecule controlled by ?1 and ?2 but not ?3 external domains

1984 • 37 citations

The class I major histocompatibility antigen gene activated in a line of SV40-transformed mouse cells is H–2Dd, not Qa/Tla

1985 • 37 citations

Qa-2 does not display structural genetic polymorphism detectable on isoelectric-focusing gels

1982 • 31 citations

The beta 1 domain of the mouse E beta chain is important for restricted antigen presentation to helper T-cell hybridomas.

1985 • 29 citations

Allospecific cytolytic T lymphocytes recognize conformational determinants on hybrid mouse transplantation antigens.

1985 • 28 citations

Expression of hybrid class I genes of the major histocompatibility complex in mouse L cells.

1985 • 27 citations

Functional and inducible expression of a transfected murine class II major histocompatibility complex gene.

1984 • 25 citations

Intron sequences reveal evolutionary relationships among major histocompatibility complex class I genes.

1985 • 23 citations

Structure and Expression of the Human Globin Genes and Murine Histoeompatability Antigen Genes

1983 • 22 citations

Gene duplications in the TL region of the mouse major histocompatibility complex.

1985 • 14 citations

History

1975 • 11 citations

Expression of structurally diverse Qa-2-encoded molecules on the surface of cloned cytotoxic T lymphocytes.

1984 • 9 citations