High‐Efficiency Gene Transfer Mediated by Adenovirus‐Polylysine‐DNA Complexes

Receptor-mediated in vitro gene transformation by a soluble DNA carrier system.

1987 • 841 citations

Transferrin-polycation conjugates as carriers for DNA uptake into cells.

1990 • 657 citations

Receptor-mediated gene delivery and expression in vivo.

1988 • 642 citations

Transferrin-polycation-DNA complexes: the effect of polycations on the structure of the complex and DNA delivery to cells.

1991 • 485 citations

Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes.

1992 • 483 citations

Adenovirus enhancement of transferrin-polylysine-mediated gene delivery.

1991 • 431 citations

Development of adenovirus vectors for the expression of heterologous genes.

1988 • 386 citations

Transferrin-polycation-mediated introduction of DNA into human leukemic cells: stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptor levels.

1990 • 340 citations

Gene transfer into hepatocytes using asialoglycoprotein receptor mediated endocytosis of DNA complexed with an artificial tetra-antennary galactose ligand

1992 • 325 citations

High-efficiency receptor-mediated delivery of small and large (48 kilobase gene constructs using the endosome-disruption activity of defective or chemically inactivated adenovirus particles.

1992 • 317 citations

Targeting Genes: Delivery and Persistent Expression of a Foreign Gene Driven by Mammalian Regulatory Elements in Vivo

1989 • 292 citations

Receptor-mediated endocytosis of transferrin-polycation conjugates: an efficient way to introduce DNA into hematopoietic cells.

1990 • 275 citations

Adenovirus-induced release of epidermal growth factor and pseudomonas toxin into the cytosol of KB cells during receptor-mediated endocytosis

1983 • 256 citations

Human adenovirus-host cell interactions: comparative study with members of subgroups B and C

1990 • 248 citations

Hepatocyte-directed gene transfer in vivo leads to transient improvement of hypercholesterolemia in low density lipoprotein receptor-deficient rabbits.

1992 • 242 citations

High-Efficiency Gene Transfer Mediated by Adenovirus Coupled to DNA–Polylysine Complexes

1992 • 234 citations

Mechanisms of DNA uptake by mammalian cells: fate of exogenously added DNA monitored by the use of fluorescent dyes.

1982 • 229 citations

The transferrin receptor

1982 • 202 citations

Early events in the interaction of adenoviruses with Hela cells

1970 • 182 citations

Viral infection permeabilizes mammalian cells to protein toxins

1980 • 178 citations

Transferrin receptors: Structure and function

1984 • 143 citations

DNA-binding transferrin conjugates as functional gene-delivery agents: synthesis by linkage of polylysine or ethidium homodimer to the transferrin carbohydrate moiety

1991 • 142 citations

Eight ‘Musts’ for Biotechnology

1988 • 116 citations

[42] Receptor-mediated transport of DNA into eukaryotic cells

1993 • 115 citations

Mechanisms of enveloped virus entry into cells.

1990 • 104 citations

Receptor-mediated endocytosis and nuclear transport of a transfecting DNA construct

1992 • 102 citations

Evidence that the penton base of adenovirus is involved in potentiation of toxicity of Pseudomonas exotoxin conjugated to epidermal growth factor.

1984 • 102 citations

Retroviral vectors for introduction of genes into mammalian cells.

1988 • 100 citations

Liposome‐mediated gene transfer

2015 • 96 citations

A novel mechanism for achieving transgene persistence in vivo after somatic gene transfer into hepatocytes.

1992 • 92 citations

Evidence for targeted gene transfer by receptor-mediated endocytosis

1990 • 92 citations

Role of vesicles during adenovirus 2 internalization into HeLa cells

1985 • 87 citations

Transferrinfection: A Highly Efficient Way to Express Gene Constructs in Eukaryotic Cells

1992 • 74 citations

Structure and Assembly of Adenoviruses

1983 • 73 citations

Binding of adenovirus and its external proteins to Triton X-114. Dependence on pH.

1985 • 66 citations

Utilization of modified surfactant-associated protein B for delivery of DNA to airway cells in culture.

1994 • 45 citations

Liposome-mediated gene transfer

1995 • 28 citations

Single breath versus panting technique in salbutamol delivery through a 750 mL spacing device

1990 • 21 citations