Temporal cortex hypermetabolism in Down syndrome prior to the onset of dementia

Statistical parametric maps in functional imaging: A general linear approach

1994 • 9,606 citations

Co-planar stereotaxic atlas of the human brain : 3-dimensional proportional system : an approach to cerebral imaging

1988 • 5,095 citations

Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease

1997 • 1,680 citations

Frequency of Stages of Alzheimer-Related Lesions in Different Age Categories

1997 • 1,599 citations

Preclinical Evidence of Alzheimer's Disease in Persons Homozygous for the ε4 Allele for Apolipoprotein E

1996 • 1,320 citations

Patterns of Brain Activation in People at Risk for Alzheimer's Disease

2000 • 1,282 citations

Positron Emission Tomography in Evaluation of Dementia

2001 • 882 citations

Cognitive Conjunction: A New Approach to Brain Activation Experiments

1997 • 844 citations

Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease

2000 • 745 citations

Mapping the evolution of regional atrophy in Alzheimer's disease: Unbiased analysis of fluid-registered serial MRI

2002 • 727 citations

Cortical glucose metabolic rate correlates of abstract reasoning and attention studied with positron emission tomography

1988 • 669 citations

Prediction of cognitive decline in normal elderly subjects with 2-[ ¹⁸ F]fluoro-2-deoxy- <scp>d</scp> -glucose/positron-emission tomography (FDG/PET)

2001 • 619 citations

A Prospective Study of Alzheimer Disease in Down Syndrome

1989 • 550 citations

Evidence from Functional Neuroimaging of a Compensatory Prefrontal Network in Alzheimer's Disease

2003 • 493 citations

Longitudinal PET Evaluation of Cerebral Metabolic Decline in Dementia: A Potential Outcome Measure in Alzheimer’s Disease Treatment Studies

2002 • 477 citations

Imaging of onset and progression of Alzheimer's disease with voxel-compression mapping of serial magnetic resonance images

2001 • 456 citations

Declining brain activity in cognitively normal apolipoprotein E ɛ4 heterozygotes: A foundation for using positron emission tomography to efficiently test treatments to prevent Alzheimer's disease

2001 • 453 citations

Neuroplasticity Failure in Alzheimer's Disease

1999 • 442 citations

Alzheimer's disease in Down's syndrome

1985 • 393 citations

Down's Syndrome and Alzheimer's disease: a review

1986 • 316 citations

Normal ageing in adults with Down's syndrome: a longitudinal study

1996 • 159 citations

Down syndrome and Alzheimer's disease: A link between development and aging

2001 • 155 citations

A voxel-based morphometric study of nondemented adults with Down Syndrome

2003 • 152 citations

Further evaluation of the Dementia Questionnaire for Persons with Mental Retardation (DMR)

1996 • 144 citations

Prevalence of dementia in adults with and without Down syndrome.

1996 • 137 citations

Comparison of rating scales for the diagnosis of dementia in adults with Down’s syndrome

1999 • 135 citations

Impairment of Neocortical Metabolism Predicts Progression in Alzheimer’s Disease

1999 • 131 citations

Further evaluation of the Dementia Questionnaire for Persons with Mental Retardation (DMR)

1996 • 97 citations

Down's Syndrome in Adults: Brain Metabolism

1983 • 68 citations

Regional Cerebral Glucose Metabolism is Normal in Young Adults with down Syndrome

1990 • 65 citations

Brain size and cerebral glucose metabolic rate in nonspecific mental retardation and down syndrome

1995 • 60 citations

Low glucose metabolism during brain stimulation in older Down's syndrome subjects at risk for Alzheimer's disease prior to dementia

1997 • 57 citations

Discordance between Traditional Pathologic and Energy Metabolic Changes in Very Early Alzheimer's Disease: Pathophysiological Implications

1999 • 47 citations

Cerebral metabolism as measured with positron emission tomography (PET) and [18F] 2-deoxy-d-glucose: Healthy aging Alzheimer's disease and down syndrome

1986 • 39 citations

Parallel Compensatory and Pathological Events Associated with Tau Pathology in Middle Aged Individuals with Down Syndrome

2003 • 39 citations

Increased glyceraldehyde 3-phosphate dehydrogenase levels in the brain of patients with Down's syndrome

1999 • 36 citations

Brain cognition and metabolism in Down syndrome adults in association with development of dementia

1996 • 30 citations

Altered brain glucose metabolism in transgenic-PFKL mice with elevated l-phosphofructokinase: in vivo NMR studies

1998 • 25 citations

Impaired brain glucose metabolism in patients with Down Syndrome

1999 • 24 citations

The dementia scale for Down's syndrome

2000 • 10 citations

[Cerebral glucose metabolism in Down syndrome using positron emission tomography].

2002 • 3 citations