Causes and consequences of proteinuria: the kidney filtration barrier and progressive renal failure

Effects of Losartan on Renal and Cardiovascular Outcomes in Patients with Type 2 Diabetes and Nephropathy

2001 • 7,165 citations

The Effect of Angiotensin-Converting-Enzyme Inhibition on Diabetic Nephropathy

1993 • 5,296 citations

The Effect of Irbesartan on the Development of Diabetic Nephropathy in Patients with Type 2 Diabetes

2001 • 2,520 citations

The Effects of Dietary Protein Restriction and Blood-Pressure Control on the Progression of Chronic Renal Disease

1994 • 2,274 citations

Positionally Cloned Gene for a Novel Glomerular Protein—Nephrin—Is Mutated in Congenital Nephrotic Syndrome

1998 • 1,822 citations

Randomised placebo-controlled trial of effect of ramipril on decline in glomerular filtration rate and risk of terminal renal failure in proteinuric, non-diabetic nephropathy

1997 • 1,775 citations

Effect of the Angiotensin-Converting–Enzyme Inhibitor Benazepril on the Progression of Chronic Renal Insufficiency

1996 • 1,759 citations

NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome

2000 • 1,420 citations

RETRACTED: Combination treatment of angiotensin-II receptor blocker and angiotensin-converting-enzyme inhibitor in non-diabetic renal disease (COOPERATE): a randomised controlled trial

2003 • 974 citations

Tubulointerstitial Changes as a Major Determinant in the Progression of Renal Damage

1992 • 951 citations

Renoprotective properties of ACE-inhibition in non-diabetic nephropathies with non-nephrotic proteinuria

1999 • 883 citations

Congenital Nephrotic Syndrome in Mice Lacking CD2-Associated Protein

1999 • 844 citations

Use of Single Voided Urine Samples to Estimate Quantitative Proteinuria

1983 • 763 citations

Nephrin is specifically located at the slit diaphragm of glomerular podocytes

1999 • 736 citations

Predictors of the progression of renal disease in the Modification of Diet in Renal Disease Study

1997 • 692 citations

Type IV collagen: structure, gene organization, and role in human diseases. Molecular basis of Goodpasture and Alport syndromes and diffuse leiomyomatosis.

1993 • 610 citations

Proteinuria, albuminuria, risk, assessment, detection, elimination (PARADE): A position paper of the National Kidney Foundation

1999 • 591 citations

POROUS SUBSTRUCTURE OF THE GLOMERULAR SLIT DIAPHRAGM IN THE RAT AND MOUSE

1974 • 555 citations

The murine nephrin gene is specifically expressed in kidney, brain and pancreas: inactivation of the gene leads to massive proteinuria and neonatal death

2001 • 520 citations

Henoch-Scho[Combining Diaeresis]nlein Purpura in Adults

2002 • 518 citations

Effect of captopril on progression to clinical proteinuria in patients with insulin-dependent diabetes mellitus and microalbuminuria. European Microalbuminuria Captopril Study Group

1994 • 494 citations

Urinary protein excretion rate is the best independent predictor of ESRF in non-diabetic proteinuric chronic nephropathies

1998 • 431 citations

Proteinuria and Perinatal Lethality in Mice Lacking NEPH1, a Novel Protein with Homology to NEPHRIN

2001 • 427 citations

The renal glomerulus of mice lacking s–laminin/laminin β2: nephrosis despite molecular compensation by laminin β1

1995 • 416 citations

Protein overload stimulates RANTES production by proximal tubular cells depending on NF-kB activation

1998 • 415 citations

Oxford Textbook of Clinical Nephrology

1992 • 367 citations

Renal expression of genes that promote interstitial inflammation and fibrosis in rats with protein-overload proteinuria

1995 • 364 citations

Effect of Captopril on Progression to Clinical Proteinuria in Patients With Insulin-Dependent Diabetes Mellitus and Microalbuminuria

1994 • 353 citations

Role of the deletion of polymorphism of the angiotensin converting enzyme gene in the progression and therapeutic responsiveness of IgA nephropathy.

1995 • 324 citations

Induction of monocyte chemoattractant protein-1 in proximal tubule cells by urinary protein.

1997 • 321 citations

Interstitial nephritis induced by protein-overload proteinuria.

1989 • 283 citations

Additive antiproteinuric effect of converting enzyme inhibitor and losartan in normotensive patients with IgA nephropathy

1999 • 246 citations

Proximal tubular cell synthesis and secretion of endothelin-1 on challenge with albumin and other proteins

1995 • 246 citations

Meta-analysis of association of insertion/deletion polymorphism of angiotensin I-converting enzyme gene with diabetic nephropathy and retinopathy

1998 • 236 citations

Heparan sulfate chains of perlecan are indispensable in the lens capsule but not in the kidney

2003 • 235 citations

Molecular basis of glomerular permselectivity

2001 • 229 citations

Polymorphisms in angiotensin-converting-enzyme gene and progression of IgA nephropathy

1995 • 214 citations

FAT is a component of glomerular slit diaphragms

2001 • 214 citations

Prognostic Indicators in Idiopathic IgA Mesangial Nephropathy

1986 • 208 citations

Quantitation of Proteinuria by the Use of Protein-to-Creatinine Ratios in Single Urine Samples

1987 • 203 citations

The role of vasoactive compounds, growth factors and cytokines in the progression of renal disease

2000 • 193 citations

Influence of Clinical and Histological Features on Actuarial Renal Survival in Adult Patients With Idiopathic IgA Nephropathy, Membranous Nephropathy, and Membranoproliferative Glomerulonephritis: Survey of the Recent Literature

1992 • 187 citations

Tubulo-interstitial lesions mediate renal damage in adriamycin glomerulopathy

1986 • 180 citations

Association between angiotensin-converting-enzyme gene polymorphism and failure of renoprotective therapy

1996 • 170 citations

Blocking Angiotensin II Synthesis/Activity Preserves Glomerular Nephrin in Rats with Severe Nephrosis

2001 • 137 citations

Add-on angiotensin receptor blockade with maximized ACE inhibition

2001 • 131 citations

A relationship between proteinuria and acute tubulointerstitial disease in rats with experimental nephrotic syndrome.

1991 • 130 citations

Proteinuria induces tubular cell turnover: A potential mechanism for tubular atrophy

1999 • 128 citations

Quantitation of proteinuria with urinary protein/creatinine ratios and random testing with dipsticks in nephrotic children

1990 • 118 citations

Proximal tubular cells promote fibrogenesis by TGF-β1–mediated induction of peritubular myofibroblasts

2002 • 113 citations

Prognostic Value of Angiotensin-I Converting Enzyme I/D Polymorphism for Nephropathy in Type 1 Diabetes Mellitus

2001 • 109 citations

Use of β2 microglobulin to diagnose tubulo-interstitial renal lesions in children

1986 • 107 citations

Albumin overload induces apoptosis in LLC-PK₁cells

2001 • 103 citations

Significance of proteinuria on the outcome of renal function in patients with focal segmental glomerulosclerosis.

1983 • 99 citations

Proteinuria and Progression in Human Glomerular Diseases

1990 • 98 citations

Recent insights into the structure and functions of heparan sulfate proteoglycans in the human glomerular basement membrane

1999 • 95 citations

Irreversible tubulointerstitial damage associated with chronic aminonucleoside nephrosis. Amelioration by angiotensin I converting enzyme inhibition.

1990 • 91 citations

Effect of angiotensin II antagonism on the regression of kidney disease in the rat

2002 • 89 citations

The structural basis of glomerular filtration.

1972 • 85 citations

Abnormal protein traffic through the glomerular barrier induces proximal tubular cell dysfunction and causes renal injury

1995 • 83 citations

Effects of dual blockade of the renin-angiotensin system in primary proteinuric nephropathies

2002 • 80 citations

Proteinuria and tubulointerstitial lesions in lupus nephritis

2001 • 78 citations

Genetic polymorphisms of the renin-angiotensin system and the outcome of focal segmental glomerulosclerosis in children

1998 • 61 citations

Renal function and structure in albuminuric type 2 diabetic patients without retinopathy

2001 • 60 citations

Angiotensin-Converting Enzyme Gene Polymorphism in Patients with Minimal-Change Nephrotic Syndrome and Focal Segmental Glomerulosclerosis

1997 • 56 citations

Gene expression profile of renal proximal tubules regulated by proteinuria

2002 • 54 citations

Nephrotic syndrome and multiple tubular defects in children: An early sign of focal segmental glomerulosclerosis

1980 • 34 citations

Slowing the progression of renal failure

2002 • 34 citations

Proximal Tubular Cell, Proteinuria and Tubulo-lnterstitial Scarring

1994 • 33 citations

Regulation of endothelin production and secretion in cultured collecting duct cells by endogenous transforming growth factor-beta.

1996 • 29 citations

Idiopathic membranous nephropathy in the elderly

1993 • 23 citations

Clinical factors in progressive renal injury. The role of proteinuria.

1991 • 22 citations

Progressive renal disease: does the quality of the proteinuria matter or only the quantity?

2000 • 22 citations

Treatment of membranous nephropathy

2001 • 21 citations

Polymorphism of the angiotensin I-Converting enzyme gene in diabetic nephropathy in Type II diabetic patients with proliferative retinopathy

1998 • 11 citations

Reversible tubular dysfunction associated with chronic renal failure in an adult patient with the nephrotic syndrome.

1974 • 8 citations

Regulation of endothelin production and secretion in cultured collecting duct cells by endogenous transforming growth factor-beta

1996 • 8 citations