Increased glucose phosphorylating activity correlates with insulin secretory capacity of male JCR:LA-corpulent rat islets

The glucose transporter family: structure, function and tissue-specific expression

1993 • 773 citations

Familial Hyperglycemia Due to Mutations in Glucokinase -- Definition of a Subtype of Diabetes Mellitus

1993 • 737 citations

Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus

1992 • 620 citations

Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus

1992 • 610 citations

Glucokinase as Glucose Sensor and Metabolic Signal Generator in Pancreatic β-Cells and Hepatocytes

1990 • 603 citations

Linkage of type 2 diabetes to the glucokinase gene

1992 • 386 citations

Glucokinase as pancreatic beta cell glucose sensor and diabetes gene.

1993 • 281 citations

Glucose metabolism in mouse pancreatic islets

1970 • 235 citations

Glucose sensing in pancreatic islet beta cells: the key role of glucokinase and the glycolytic intermediates.

1993 • 209 citations

Glucokinase mutations associated with non-insulin-dependent (type 2) diabetes mellitus have decreased enzymatic activity: implications for structure/function relationships.

1993 • 202 citations

Obese spontaneously hypertensive rats—A model for study of atherosclerosis

1973 • 195 citations

New perspectives on pancreatic islet glucokinase

1984 • 165 citations

A method for deriving kinetic constants for two enzymes acting on the same substrate

1971 • 165 citations

Concordant Glucose Induction of Glucokinase, Glucose Usage, and Glucose-Stimulated Insulin Release in Pancreatic Islets Maintained in Organ Culture

1992 • 162 citations

Pathologic findings and laboratory data in a new strain of obese hypertensive rats.

1975 • 153 citations

THE EFFECT OF PANCREAS TRANSPLANTATION ON DIABETIC POLYNEUROPATHY

1988 • 100 citations

Identification of Glucokinase Mutations in Subjects With Gestational Diabetes Mellitus

1993 • 98 citations

GLUT2 Expression and Function in β-cells of GK rats with NIDDM: Dissociation Between Reductions in Glucose Transport and Glucose-Stimulated Insulin Secretion

1993 • 80 citations

Monolayer Culture of Adult Rat Pancreatic Islets on Extracellular Matrix: Modulation of B-Cell Function by Chronic Exposure to High Glucose*

1991 • 77 citations

Insulin resistance and impaired glucose tolerance in the atherosclerosis-prone LA/N corpulent rat.

1987 • 77 citations

Mechanism of compensatory hyperinsulinemia in normoglycemic insulin-resistant spontaneously hypertensive rats. Augmented enzymatic activity of glucokinase in beta-cells.

1994 • 76 citations

Expression of yeast hexokinase in pancreatic beta cells of transgenic mice reduces blood glucose, enhances insulin secretion, and decreases diabetes.

1992 • 75 citations

Expression and function of GLUT-1 and GLUT-2 glucose transporter isoforms in cells of cultured rat pancreatic islets.

1992 • 73 citations

PANCREATIC ISLET ISOLATION IN RATS WITH DUCTAL COLLAGENASE DISTENTION, STATIONARY DIGESTION, AND DEXTRAN SEPARATION

1988 • 73 citations

Glucokinase and candidate genes for Type 2 (non-insulin-dependent) diabetes mellitus

1993 • 71 citations

Effects of High Glucose on Insulin Secretion by Isolated Rat Islets and Purified β-Cells and Possible Role of Glycosylation

1989 • 69 citations

Abnormal insulin and glucose metabolism in the JCR:LA-corpulent rat

1994 • 68 citations

Energy Metabolism in Human Erythrocytes

1971 • 67 citations

Serum lipids and lipoproteins in the atherosclerosis prone LA/N corpulent rat

1987 • 66 citations

Atherogenesis in two strains of obese rats The fatty Zucker and LA/N-corpulent

1988 • 62 citations

Structure/function studies of human beta-cell glucokinase. Enzymatic properties of a sequence polymorphism, mutations associated with diabetes, and other site-directed mutants

1993 • 59 citations

Myocardial and vascular lesions in the LA/N-corpulent rat

1986 • 59 citations

Hexokinases and glucokinases

1990 • 51 citations

Glucokinase and glucose transporter expression in liver and islets: implications for control of glucose homoeostasis

1990 • 46 citations

Increased Catalytic Activity of Glucokinase in Isolated Islets From Hyperinsulinemic Rats

1994 • 41 citations

In situ glucose uptake and glucokinase activity of pancreatic islets in diabetic and obese rodents.

1994 • 39 citations

Gastric Inhibitory Polypeptide (GIP) and Insulin Release in the Obese Zucker Rat

1984 • 36 citations

Comparison of the enteroinsular axis in two strains of obese rat, the fatty Zucker and the JCR:LA-corpulent.

1991 • 34 citations

Dynamics of insulin hypersecretion by obese Zucker rats

1985 • 32 citations

Effect of 2-Bromostearate on Glucose-Phosphorylating Activities and the Dynamics of Insulin Secretion in Islets of Langerhans During Fasting

1984 • 31 citations

Fundamentals of Enzymology, 2nd edn

1990 • 29 citations

Hormonal and Lipogenic and Gluconeogenic Enzymatic Responses in LA/N-Corpulent Rats

1985 • 26 citations

Evidence for defective glucose sensing by islets of fa/fa obese Zucker rats

1993 • 26 citations

In vivo and in vitro increased pancreatic beta-cell sensitivity to glucose in normal rats submitted to a 48-h hyperglycaemic period

1993 • 24 citations

Age-related qualitative and quantitative changes in the endocrine pancreas of the LA/N-corpulent rat.

1987 • 22 citations

Effect of pertussis toxin on islet insulin secretion in obese (fa/fa) Zucker rats

1991 • 18 citations

High Km of GLUT-2 glucose transporter does not explain its role in insulin secretion

1993 • 16 citations

Identification of Biochemical Defects in Pancreatic Islets of fa/fa Rats: A Developmental Study

1995 • 15 citations

Genetically obese rats with () and without diabetes () share abnormal islet responses to glucose

1992 • 15 citations

Glucokinase, glucose sensing, and diabetes.

1993 • 14 citations

Defective regulation of glucokinase in rat pancreatic islet cell tumours

1987 • 14 citations

Pancreatic hypersensitivity to glucose by young obese Zucker rats ()

1988 • 13 citations

Glucokinase activity in isolated islets from obese fa/fa Zucker rats

1993 • 11 citations

Regulation of insulin secretion by nutrients: the fuel concept

1992 • 8 citations

Failure to detect cytomegalovirus DNA in pancreas in type 2 diabetes

1992 • 4 citations