Structural analysis of caspase-1 inhibitors derived from Tethering

PROCHECK: a program to check the stereochemical quality of protein structures

1993 • 23,689 citations

Refinement of Macromolecular Structures by the Maximum-Likelihood Method

1997 • 14,729 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

The Inflammasome

2002 • 5,445 citations

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

Accurate bond and angle parameters for X-ray protein structure refinement

1991 • 2,467 citations

Molecular mechanisms of caspase regulation during apoptosis

2004 • 1,851 citations

Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme

1995 • 1,625 citations

Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock

1995 • 1,413 citations

The finer things in X-ray diffraction data collection

1999 • 1,242 citations

Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN- γ production

1997 • 1,172 citations

Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme

1997 • 1,137 citations

Molecular Cloning of the Interleukin-1β Converting Enzyme

1992 • 1,115 citations

Efficient anisotropic refinement of macromolecular structures using FFT

1999 • 943 citations

SFCHECK: a unified set of procedures for evaluating the quality of macromolecular structure-factor data and their agreement with the atomic model

1999 • 874 citations

Structure and mechanism of interleukin-lβ converting enzyme

1994 • 842 citations

Murine Caspase-11, an ICE-Interacting Protease, Is Essential for the Activation of ICE

1998 • 687 citations

Implementation of molecular replacement in AMoRe

2001 • 621 citations

Interleukin‐1β, Interleukin‐18, and the Interleukin‐1β Converting Enzyme^a

1998 • 495 citations

Autoproteolytic Activation of Pro-Caspases by Oligomerization

1998 • 424 citations

Tethering: Fragment-Based Drug Discovery

2004 • 374 citations

IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31-kDa IL-1 alpha.

1991 • 324 citations

Dual Role of Caspase-11 in Mediating Activation of Caspase-1 and Caspase-3 under Pathological Conditions

2000 • 319 citations

A combinatorial approach for determining protease specificities: application to interleukin-1β converting enzyme (ICE)

1997 • 255 citations

In situ assembly of enzyme inhibitors using extended tethering

2003 • 193 citations

Incorporation of Prior Phase Information Strengthens Maximum-Likelihood Structure Refinement

1998 • 190 citations

Interleukin-1 beta converting enzyme requires oligomerization for activity of processed forms in vivo.

1995 • 133 citations

Expression, Refolding, and Autocatalytic Proteolytic Processing of the Interleukin-1β-converting Enzyme Precursor

1995 • 107 citations

Identification of Potent and Selective Small-Molecule Inhibitors of Caspase-3 through the Use of Extended Tethering and Structure-Based Drug Design

2002 • 104 citations

Proteases, proteolysis, and apoptosis.

1998 • 79 citations

High-Throughput Screening of Enzyme Inhibitors: Simultaneous Determination of Tight-Binding Inhibition Constants and Enzyme Concentration

2000 • 59 citations

Prospects for Caspase Inhibitors

2004 • 59 citations

Preparation and evaluation of peptidic aspartyl hemiacetals as reversible inhibitors of interleukin‐l β converting enzyme (ICE)

1994 • 58 citations

Making drugs on proteins: site-directed ligand discovery for fragment-based lead assembly

2004 • 58 citations

Crystal Structures of a Ligand-free and Malonate-Bound Human Caspase-1

2004 • 54 citations

Discovery and Characterization of Cooperative Ligand Binding in the Adaptive Region of Interleukin-2

2003 • 46 citations

Identification of potent and novel small-Molecule inhibitors of caspase-3

2003 • 25 citations