A Mutational Study of the Peptide-binding Domain of Hsc70 Guided by Secondary Structure Prediction

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Molecular chaperones in cellular protein folding

1996 • 3,540 citations

Spectroscopic Determination of Tryptophan and Tyrosine in Proteins^*

1967 • 3,423 citations

Structural Analysis of Substrate Binding by the Molecular Chaperone DnaK

1996 • 1,247 citations

Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein

1990 • 1,035 citations

Peptide Binding and Release by Proteins Implicated as Catalysts of Protein Assembly

1989 • 763 citations

Uncoating ATPase is a member of the 70 kilodalton family of stress proteins

1986 • 607 citations

Identification of a regulatory motif in Hsp70 that affects ATPase activity, substrate binding and interaction with HDJ-1.

1995 • 428 citations

Interaction of hsp70 with unfolded proteins: effects of temperature and nucleotides on the kinetics of binding.

1991 • 332 citations

The 70-kd mammalian heat shock proteins are structurally and functionally related to the uncoating protein that releases clathrin triskelia from coated vesicles.

1985 • 301 citations

Common and divergent peptide binding specificities of hsp70 molecular chaperones.

1994 • 283 citations

The ATPase core of a clathrin uncoating protein.

1987 • 259 citations

Tritium labeling of proteins to high specific radioactivity by reduction methylation.

1980 • 206 citations

A hypothetical model for the peptide binding domain of hsp70 based on the peptide binding domain of HLA.

1991 • 191 citations

Identification of the peptide binding domain of hsc70. 18-Kilodalton fragment located immediately after ATPase domain is sufficient for high affinity binding.

1993 • 166 citations

Constitutively Expressed Rat mRNA Encoding a 70-Kilodalton Heat-Shock-Like Protein

1985 • 164 citations

Unfolded proteins stimulate molecular chaperone Hsc70 ATPase by accelerating ADP/ATP exchange

1992 • 132 citations

Which came first, MHC class I or class II?

1991 • 132 citations

Molecular chaperones: towards a characterization of the heat-shock protein 70 family

1997 • 120 citations

Dissociation of clathrin from coated vesicles by the uncoating ATPase.

1990 • 109 citations

Hsc70-binding Peptides Selected from a Phage Display Peptide Library that Resemble Organellar Targeting Sequences

1995 • 105 citations

The Peptide-Binding Domain of the Chaperone Protein Hsc70 Has an Unusual Secondary Structure Topology

1995 • 91 citations

Solution small-angle x-ray scattering study of the molecular chaperone Hsc70 and its subfragments

1995 • 90 citations

Current Research in Protein Chemistry

1990 • 83 citations

Multiple alanine replacements within α‐helix 126–134 of T4 lysozyme have independent, additive effects on both structure and stability

1992 • 61 citations

Secondary structure of the mammalian 70-kilodalton heat shock cognate protein analyzed by circular dichroism spectroscopy and secondary structure prediction

1990 • 60 citations

The COOH-terminal Peptide Binding Domain Is Essential for Self-association of the Molecular Chaperone HSC70

1997 • 56 citations

Conformations of the Nucleotide and Polypeptide Binding Domains of a Cytosolic Hsp70 Molecular Chaperone Are Coupled

1996 • 56 citations

A functional decaisoleucine-containing signal sequence. Construction by cassette mutagenesis.

1988 • 41 citations

High-level expression of soluble rat hsc70 in Escherichia coli: purification and characterization of the cloned enzyme

1993 • 31 citations

Involvement of the 10-kDa C-Terminal Fragment of hsc70 in Complexing with Unfolded Protein

1996 • 30 citations