Cytokines and other mediators in rheumatoid arthritis

Leukotrienes: Mediators of Immediate Hypersensitivity Reactions and Inflammation

1983 • 2,839 citations

Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes

1980 • 2,099 citations

EICOSAPENTAENOIC ACID AND PREVENTION OF THROMBOSIS AND ATHEROSCLEROSIS?

1978 • 1,689 citations

Interleukin-1

1984 • 1,625 citations

"Panning" for lymphocytes: a method for cell selection.

1978 • 1,319 citations

Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli

1983 • 1,241 citations

Structure and expression of a cloned cDNA for human interleukin-2

1983 • 1,176 citations

Free Radicals and Inflammation: Protection of Synovial Fluid by Superoxide Dismutase

1974 • 1,109 citations

Angiogenesis in vitro

1980 • 1,041 citations

Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response.

1981 • 1,030 citations

An interleukin 1 like factor stimulates bone resorption in vitro

1983 • 1,017 citations

Anti-inflammatory steroids induce biosynthesis of a phospholipase A2 inhibitor which prevents prostaglandin generation

1979 • 928 citations

A phospholipase A2 inhibitory protein in rabbit neutrophils induced by glucocorticoids.

1980 • 841 citations

Regulation of the immune response by prostaglandins

1983 • 717 citations

Expression of human immune interferon cDNA in E. coli and monkey cells

1982 • 703 citations

Biologic properties of homogeneous interleukin 3. I. Demonstration of WEHI-3 growth factor activity, mast cell growth factor activity, P cell-stimulating factor activity, colony-stimulating factor activity, and histamine-producing cell-stimulating factor activity

1983 • 702 citations

Interstitial Lung Diseases of Unknown Cause

1984 • 696 citations

Prostaglandins, Arachidonic Acid, and Inflammation

1980 • 690 citations

RHEUMATOID ARTHRITIS: A DISEASE OF T-LYMPHOCYTE/MACROPHAGE IMMUNOREGULATION

1981 • 670 citations

The class II molecules of the human and murine major histocompatibility complex

1984 • 664 citations

Stimulation of rheumatoid synovial cell collagenase and prostaglandin production by partially purified lymphocyte-activating factor (interleukin 1).

1981 • 614 citations

Biological Activity of Recombinant Human Interleukin-2 Produced in Escherichia coli

1984 • 600 citations

The Immunopathology of Joint Inflammation in Rheumatoid Arthritis

1973 • 561 citations

Production of collagenase and prostaglandins by isolated adherent rheumatoid synovial cells.

1976 • 555 citations

Prostaglandins modulate macrophage Ia expression

1982 • 545 citations

Nucleotide sequence of epidermal growth factor cDNA predicts a 128,000-molecular weight protein precursor

1983 • 520 citations

Structure of the human immune interferon gene

1982 • 510 citations

Molecular cloning of cDNA for murine interleukin-3

1984 • 485 citations

Mediation of local homeostasis and inflammation by leukotrienes and other mast cell-dependent compounds

1981 • 477 citations

Prostaglandin I3 is formed in vivo in man after dietary eicosapentaenoic acid

1984 • 476 citations

Interstitial Lung Diseases of Unknown Cause

1984 • 472 citations

Hemopoietic colony-stimulating factors

1984 • 468 citations

Systemic Lupus Erythematosus: Presence in Human Serum of an Unusual Acid-Labile Leukocyte Interferon

1982 • 460 citations

Defective production of interleukin 1 and interleukin 2 in patients with systemic lupus erythematosus (SLE).

1983 • 453 citations

Isolation of an interleukin‐1‐like factor from human joint effusions

1983 • 450 citations

Structure of a Mouse Submaxillary Messenger RNA Encoding Epidermal Growth Factor and Seven Related Proteins

1983 • 448 citations

Concomitant secretion of prourokinase and of a plasminogen activator-specific inhibitor by cultured human monocytes-macrophages.

1984 • 418 citations

Isolation and characterization of a mouse cDNA clone that expresses mast-cell growth-factor activity in monkey cells.

1984 • 365 citations

Lymphocyte-Mediated Activation of Fibroblast Proliferation and Collagen Production

1978 • 358 citations

Regulation of Bone Formation

1983 • 339 citations

Analysis of T cell function in autoimmune murine strains. Defects in production and responsiveness to interleukin 2.

1981 • 334 citations

Dietary enrichment with the polyunsaturated fatty acid eicosapentaenoic acid prevents proteinuria and prolongs survival in NZB x NZW F1 mice.

1981 • 328 citations

Lymphokine stimulation of collagen accumulation.

1976 • 322 citations

Nucleotide sequence of cloned cDNA of human c-myc oncogene

1983 • 316 citations

Molecular cloning of human interleukin 2 cDNA and its expression inE. coli

1983 • 307 citations

Nonimmunological Production pf Leukotrienes Induced by Platelet-Activating Factor

1982 • 305 citations

Interleukin 1 activity in the synovial fluid of patients with rheumatoid arthritis

1982 • 304 citations

Ia+ T Cells in Synovial Fluid And Tissues of Patients with Rheumatoid Arthritis

1981 • 296 citations

Activity of a Macrophage Factor in Collagen Formation by Silica

1967 • 293 citations

Participation of monocyte-macrophages and lymphocytes in the production of a factor that stimulates collagenase and prostaglandin release by rheumatoid synovial cells.

1979 • 283 citations

α1-Antitrypsin deficiency detection by direct analysis of the mutation in the gene

1983 • 277 citations

Chemotaxis of polymorphonuclear leukocytes from patients with rheumatoid arthritis

1971 • 268 citations

Effect of Prostaglandin E1 on Adjuvant Arthritis

1971 • 264 citations

Collagen: Structure, function, and metabolism in normal and fibrotic tissues

1983 • 264 citations

Interleukin 1 is more than an interleukin

1982 • 257 citations

[52] Mammalian collagenases

1981 • 219 citations

Cellular Sensitivity to Collagen in Rheumatoid Arthritis

1978 • 211 citations

Articular mastocytosis in rheumatoid arthritis

1984 • 210 citations

HEPATOCYTE‐STIMULATING FACTOR: A MONOCYTE‐DERIVED ACUTE‐PHASE REGULATORY PROTEIN

1983 • 207 citations

Identification of Three Major Synovial Lining Cell Populations by Monoclonal Antibodies Directed to Ia Antigens and Antigens Associated with Monocytes/Macrophages and Fibroblasts

1983 • 204 citations

Molecular cloning of human immune interferon cDNA and its expression in eukaryotic cells

1982 • 192 citations

1 alpha,25-dihydroxyvitamin D3 induces maturation of the human monocyte cell line U937, and, in association with a factor from human T lymphocytes, augments production of the monokine, mononuclear cell factor.

1984 • 189 citations

The mechanisms of inhibition of human IL 2 production. II. PGE2 induction of suppressor T lymphocytes.

1984 • 186 citations

lDirect Stimulation of Bone Resorption by Epidermal Growth Factor*

1980 • 182 citations

Prostaglandins as mediators of inflammation.

1976 • 177 citations

Regulation of human peripheral blood monocyte DR antigen expression in vitro by lymphokines and recombinant interferons.

1984 • 169 citations

Inhibition by Retinoic Acid of Collagenase Production in Rheumatoid Synovial Cells

1980 • 164 citations

Multiple interferons in the circulation of patients with systemic lupus erythematosus and vasculitis

1982 • 162 citations

Specific cleavage of human type III collagen by human polymorphonuclear leukocyte elastase.

1980 • 159 citations

Presence of autoantibody for phospholipase inhibitory protein, lipomodulin, in patients with rheumatic diseases.

1981 • 157 citations

The effect and interaction of bradykinin and prostaglandins on protein and collagen production by lung fibroblasts.

1982 • 147 citations

Electron microscopic observations of immunoreactive cells in the rheumatoid synovial membrane

1976 • 146 citations

Analysis of the defects responsible for the impaired regulation of Epstein-Barr virus-induced B cell proliferation by rheumatoid arthritis lymphocytes. I. Diminished gamma interferon production in response to autologous stimulation.

1983 • 146 citations

Inhibition of collagen synthesis by mononuclear cell supernates.

1979 • 142 citations

Lymphokines in the rheumatoid joint

1975 • 140 citations

Rat alpha 1-acid glycoprotein mRNA. Cloning of double-stranded cDNA and kinetics of induction of mRNA levels following acute inflammation.

1981 • 139 citations

Human synovium releases a factor which stimulates chondrocyte production of PGE and plasminogen activator

1980 • 134 citations

Modulation of surface antigens of a human monocyte cell line, U937, during incubation with T lymphocyte-conditioned medium: detection of T4 antigen and its presence on normal blood monocytes.

1983 • 126 citations

Interactions among rheumatoid synovial cells and monocyte-macrophages: production of collagenase-stimulating factor by human monocytes exposed to concanavalin A or immunoglobulin Fc fragments.

1980 • 122 citations

Triene prostaglandins: Prostaglandin D ₃ and icosapentaenoic acid as potential antithrombotic substances

1979 • 122 citations

Association in normal human fibroblasts of elevated levels of adenosine 3‘:5‘-monophosphate with a selective decrease in collagen production.

1978 • 116 citations

Phagocytic Function of Polymorphonuclear Leukocytes in Rheumatic Diseases

1973 • 114 citations

Histamine

1976 • 110 citations

Release, purification, and characterization of platelet-activating factor (PAF)

1980 • 109 citations

Isolation of the receptor for IgG from a human monocyte cell line (U937) and from human peripheral blood monocytes.

1982 • 108 citations

Prostaglandins and inflammation

1980 • 107 citations

Cell-mediated immunity to collagen and collagen α chains in rheumatoid arthritis and other rheumatic diseases

1980 • 106 citations

Kinetics of induction and molecular size of mRNAs encoding human interleukin-2 and γ-interferon

1982 • 104 citations

Effects of human mononuclear cell factor on cultured rheumatoid synovial cells

1979 • 101 citations

Identification and characterization of human haptoglobin cDNA.

1983 • 101 citations

Changes in vascular endothelium related to lymphocyte collections in diseased synovia

1983 • 101 citations

The relation of experimental arthritis to the distribution of streptococcal cell wall fragments.

1980 • 99 citations

Isolation of genomic DNA clones spanning the entire fibronectin gene.

1983 • 99 citations

Analysis of the defects responsible for the impaired regulation of EBV-induced B cell proliferation by rheumatoid arthritis lymphocytes. II. Role of monocytes and the increased sensitivity of rheumatoid arthritis lymphocytes to prostaglandin E.

1983 • 98 citations

Isolation of Human C-Reactive Protein Complementary DNA and Localization of the Gene to Chromosome 1

1983 • 95 citations

ANGIOGENIC FACTOR FROM SYNOVIAL FLUID RESEMBLING THAT FROM TUMOURS

1980 • 93 citations

Fibronectin in synovial fluid and tissue in rheumatoid arthritis

1981 • 91 citations

Characterization of the immunocompetent cells of rheumatoid synovium from tissue sections and eluates

1981 • 91 citations

Early joint lesions of rheumatoid arthritis; report of eight cases, with knee biopsies of lesions of less than one year's duration.

1955 • 90 citations

Effect of hormones and growth factors on alkaline phosphatase activity and collagen synthesis in cultured rat calvariae

1983 • 90 citations

Two phospholipase pools for prostaglandin synthesis in macrophages

1981 • 89 citations

A precursor form of latent collagenase produced in a cell-free system with mRNA from rabbit synovial cells.

1981 • 88 citations

Regulation of Collagen Production by the β-Adrenergic System

1981 • 83 citations

Extracellular phospholipase A2 mediates inflammatory hyperaemia

1981 • 82 citations

Analysis of T cell subsets in the peripheral blood and synovial fluid of patients with rheumatoid arthritis by means of monoclonal antibodies.

1983 • 82 citations

Characterization of blood mononuclear cells of rheumatoid arthritis patients

1982 • 81 citations

Purification to homogeneity of pig leucocyte catabolin, a protein that causes cartilage resorption in vitro

1983 • 81 citations

Prostaglandin E1 inhibits T-cell proliferation and renal disease in mice

1981 • 80 citations

Regulation of immune response by components of the complement cascade and their activated fragments

1983 • 78 citations

Stimulation of collagenase production by collagen in mammalian cell cultures

1979 • 78 citations

Identification of plasma kallikrein as an activator of latent collagenase in rheumatoid synovial fluid

1982 • 73 citations

Synthesis of complement by macrophages and modulation of their functions through complement activation

1983 • 72 citations

Isolation of cDNA sequences coding for a part of human tissue plasminogen activator.

1983 • 71 citations

Inducer-responsive expression of the cloned human interferonβ₁gene introduced into cultured mouse cells

1982 • 70 citations

Connective tissue activation

1979 • 66 citations

Pathogenesis of rheumatoid arthritis: A vascular hypothesis

1982 • 65 citations

Histamine and Immune Responses

1982 • 65 citations

Heberden Oration 1980: aspects of the cell biology of the rheumatoid synovial lesion.

1981 • 58 citations

Interleukin 2‐independent stimulation of rabbit chondrocyte collagenase and prostaglandin E₂ production by an interleukin 1‐like factor

1984 • 58 citations

Pathogenesis of Rheumatoid Arthritis

1984 • 57 citations

The involvement of interdigitating (antigen-presenting) cells in the pathogenesis of rheumatoid arthritis.

1983 • 56 citations

Effects of products from macrophages, blood mononuclear cells and of retinol on collagenase secretion and collagen synthesis in chondrocyte culture

1982 • 54 citations

Serotonin content of platelets in inflammatory rheumatic diseases

1983 • 54 citations

Activation of neutrophils and the lesions of rheumatoid arthritis.

1982 • 54 citations

Self-associating IgG rheumatoid factors stimulate monocytes to release prostaglandins and mononuclear cell factor that stimulates collagenase and prostaglandin production by synovial cells

1983 • 54 citations

Enhanced production of IgE and IgG antibodies associated with a diet enriched in eicosapentaenoic acid.

1982 • 53 citations

Mononuclear phagocytes osteoclasts and bone resorption

1981 • 53 citations

Rheumatoid synovial cell morphologic changes induced by a mononuclear cell factor in culture

1983 • 53 citations

Role of lipomodulin, a phospholipase inhibitory protein, in immunoregulation by thymocytes.

1983 • 52 citations

Suppression of acute and chronic inflammation by orally administered prostaglandins

1981 • 50 citations

Release of platelet‐activating factor (PAF‐acether) and leukotrienes C and D from inflammatory macrophages

1982 • 48 citations

The demonstration of an interleukin-2 like activity in the synovial fluids of rheumatoid arthritis patients.

1983 • 46 citations

INTERACTION OF THE CLOTTING, KININ‐FORMING, COMPLEMENT, AND FIBRINOLYTIC PATHWAYS IN INFLAMMATION

1982 • 45 citations

Regulation of IgM rheumatoid factor production in lymphocyte cultures from young and old subjects.

1982 • 44 citations

CHARACTERIZATION OF A LEUKOCYTE‐DERIVED ENDOGENOUS MEDIATOR RESPONSIBLE FOR INCREASED PLASMA FIBRINOGEN

1982 • 44 citations

Streptococcal cell walls and synovial cell activation. Stimulation of synovial fibroblast plasminogen activator activity by monocytes treated with group A streptococcal cell wall sonicates and muramyl dipeptide.

1982 • 43 citations

Modulation of synovial cell products by a factor from a human cell line: T lymphocyte induction of a mononuclear cell factor.

1982 • 43 citations

Effect of Epidermal Growth Factor on Collagen Synthesis in Osteoblastic Cells Derived from Newborn Mouse Calvaria

1982 • 42 citations

Effects of prostaglandin E2, indomethacin, trifluoperazine and drugs affecting the cytoskeleton on collagenase production by cultured adherent rheumatoid synovial cells

1984 • 42 citations

Monocyte-macrophage system and bone resorption.

1983 • 41 citations

A REGULATORY PATHWAY FOR FIBRINOGEN BIOSYNTHESIS INVOLVING AN INDIRECT FEEDBACK LOOP

1982 • 41 citations

The Insulin Receptor of a Human Monocyte-Like Cell Line: Characterization and Function*

1984 • 41 citations

Serotonin-Induced Production of a Monocyte Chemotactic Factor by Human Peripheral Blood Leukocytes

1976 • 41 citations

Modulation of Type I and Type III Collagen Production in Normal and Mutant Human Skin Fibroblasts by Cell Density, Prostaglandin E2 and Epidermal Growth Factor

1982 • 41 citations

Regulation of Synthesis of Amyloid A‐Related Protein*

1982 • 41 citations

Interferon in synovial fluid and serum of patients with rheumatic disease.

1983 • 39 citations

Administration of nonsteroidal anti-inflammatory agents in patients with rheumatoid arthritis. Effects on indexes of cellular immune status and serum rheumatoid factor levels

1983 • 35 citations

Collagens Act as Ligands to Stimulate Human Monocytes to Produce Mononuclear Cell Factor (MCF) and Prostaglandins (PGE2)

1982 • 35 citations

Differentiation of a histiocytic lymphoma cell line by lipomodulin, a phospholipase inhibitory protein

1983 • 34 citations

GROWTH FACTORS FROM PLATELETS, MONOCYTES, AND ENDOTHELIUM: THEIR ROLE IN CELL PROLIFERATION*

1982 • 33 citations

Presence of HLA-DR antigen on synovial type A and B cells: an immunoelectron microscopic study in rheumatoid arthritis, osteoarthritis and normal traumatic joints.

1983 • 33 citations

The effects of in vivo hydrocortisone on lymphocyte‐mediated cytotoxicity

1984 • 31 citations

Biosynthesis and postsynthetic processing of human C-reactive protein.

1983 • 30 citations

Cloning of interleukin 2 mRNAs from human tonsils

1983 • 29 citations

The Interaction of Immunocompetent Cells and Chronic Inflammation as Exemplified by Rheumatoid Arthritis

1978 • 28 citations

Messenger RNA for Human Tissue Plasminogen Activator

1982 • 28 citations

Hyaluronic acid produced by human synovial fibroblasts. Effect of polyinosinic‐polycytidylic acid (POLY I:C) and interferon

1976 • 27 citations

Induction of interleukin 1 messenger RNA and translation in oocytes.

1984 • 27 citations

Treatment of murine immune complex glomerulonephritis with prostaglandin E2: Dose-response of immune complex deposition, antibody synthesis, and glomerular damage

1983 • 26 citations

VASOACTIVE PEPTIDES DERIVED FROM DEGRADATION OF FIBRINOGEN AND FIBRIN

1983 • 25 citations

Structure and expression of the C3 gene

1983 • 25 citations

Immune modulation of connective tissue functions: Studies on the production of collagen synthesis inhibitory factor by populations of human peripheral blood mononuclear cells

1982 • 24 citations

Enhanced fibroblast collagen production by a macrophage-derived factor (CEMF)

1982 • 24 citations

CLONING OF FIBRINOGEN GENES AND THEIR cDNA

1983 • 23 citations

Rheumatoid synovial cell hormone responses modulated by cell-cell interactions

1984 • 23 citations

Inhibition of human lung fibroblast growth by mononuclear cells.

1982 • 21 citations

EFFECT OF POLYMORPHONUCLEAR LEUKOCYTES ON SYNOVIAL CELL COLLAGENASE PRODUCTION

1982 • 21 citations

Effect of a mononuclear cell culture medium on collagen and glycosaminoglycan production by synovial cells in culture

1981 • 21 citations

Effect of gold sodium thiomalate on proliferation of human rheumatoid synovial cells and on collagen synthesis in tissue culture

1980 • 20 citations

Mechanism of stimulation of prostaglandin synthesis by a factor from rheumatoid synovial tissue.

1981 • 19 citations

Ia specific antilymphocyte antibodies in rheumatoid arthritis

1983 • 19 citations

Translation of mRNA for human granulocyte–macrophage colony stimulating factor

1982 • 18 citations

The significance of fibronectin in rheumatoid arthritis

1984 • 18 citations

T‐Cell Immunoregulatory Functions in Rheumatoid Arthritis Patients

1983 • 18 citations

Inflammatory synovial tissue mononuclear cells release leucocyte migration inhibition factor in antigen- and mitogen-free cultures.

1981 • 14 citations

REGULATION AND CHARACTERIZATION OF THE mRNAs FOR THE Aα, Bβ AND γ CHAINS OF FIBRINOGEN

1983 • 14 citations

The effect of lymphokines on proliferation and collagen synthesis of cultured human synovial cells

1982 • 13 citations

Isoelectric focusing of macrophage culture media and the effect of the fractions on the synthesis of DNA and collagen by fibroblasts.

1979 • 12 citations

Which proteinases degrade cartilage matrix ?

1981 • 11 citations

Release of the lymphokine osteoclast activating factor requires cyclic AMP accumulation

1982 • 11 citations

Transformation of the capillary wall elements in synovial tissue in rheumatoid arthritis.

1979 • 11 citations

Production of mononuclear cell factor by mononuclear phagocytes from rheumatoid synovial fluid.

1985 • 11 citations

Phagocytosis, bactericidal capacity, and PGE2 production of monocytes in systemic lupus erythematosus and rheumatoid arthritis.

1984 • 10 citations

Migration inhibition factor-like activity in inflammatory synovial fluids might be due to proteases.

1976 • 10 citations

Lymphocytotoxins in rheumatoid arthritis: prevalence, lymphocyte specificity, and HLA-DR antigens.

1981 • 10 citations

Transaltion of lymphocyte mRNA for mouse colony stimulating factor

1983 • 8 citations

Prostaglandin-mediated immunoregulation: reduced sensitivity of in vitro immunoglobulin production to indomethacin in rheumatoid arthritis.

1983 • 7 citations

TRANSLATIONAL AND COTRANSLATIONAL EVENTS IN FIBRINOGEN SYNTHESIS*

1983 • 7 citations

The effect of rheumatoid synovial fluid macrophages on DNA, glycosaminoglycan and collagen synthesis by synovial fibroblasts

1983 • 6 citations

Macrophage migration inhibitory factor in rheumatoid pericarditis

1977 • 6 citations

Spontaneous Release of Leucocyte Migration‐Inhibitory Factor by Mononuclear Cells Eluted from Rheumatoid Synovial Tissue

1980 • 4 citations

[Structural organization of rat ceruloplasmin gene].

1981 • 3 citations

Regulation of immune and inflammatory responses by interleukin 1

1982 • 3 citations

A study of lymphocytotoxins in the sera of families of patients with rheumatoid disease

1984 • 3 citations

The interleukins: Immunoregulatory molecules

1983 • 2 citations

Lipid and peptide mediators of inflammation. Summary.

1983 • 1 citations