Three circadian clock genes Per2, Arntl, and Npas2 contribute to winter depression

Diagnostic and Statistical Manual of Mental Disorders

2013 • 95,283 citations

Mfold web server for nucleic acid folding and hybridization prediction

2003 • 12,790 citations

dbSNP: the NCBI database of genetic variation

2001 • 6,995 citations

A self-assessment questionnaire to determine morningness- eveningness in human circadian rhythms

1976 • 4,614 citations

Seasonal Affective Disorder

1984 • 2,272 citations

Efficiency and power in genetic association studies

2005 • 1,703 citations

ESEfinder: a web resource to identify exonic splicing enhancers

2003 • 1,543 citations

Mop3 Is an Essential Component of the Master Circadian Pacemaker in Mammals

2000 • 1,523 citations

Interacting Molecular Loops in the Mammalian Circadian Clock

2000 • 1,332 citations

A Functional Genomics Strategy Reveals Rora as a Component of the Mammalian Circadian Clock

2004 • 1,046 citations

Genome-wide strategies for detecting multiple loci that influence complex diseases

2005 • 897 citations

Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor

2003 • 887 citations

Differential Functions of mPer1, mPer2, and mPer3 in the SCN Circadian Clock

2001 • 876 citations

System-level identification of transcriptional circuits underlying mammalian circadian clocks

2005 • 765 citations

Antidepressant and Circadian Phase-Shifting Effects of Light

1987 • 712 citations

The mPer2 gene encodes a functional component of the mammalian circadian clock

1999 • 692 citations

Exonic splicing enhancers: mechanism of action, diversity and role in human genetic diseases

2000 • 689 citations

Alternative splicing: multiple control mechanisms and involvement in human disease

2002 • 643 citations

The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption

2004 • 578 citations

PAS is a dimerization domain common to Drosophila Period and several transcription factors

1993 • 515 citations

Characterization of a Subset of the Basic-Helix-Loop-Helix-PAS Superfamily That Interacts with Components of the Dioxin Signaling Pathway

1997 • 510 citations

What makes a good genetic association study?

2005 • 476 citations

Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stability

2005 • 476 citations

Association of intrinsic circadian period with morningness–eveningness, usual wake time, and circadian phase.

2001 • 461 citations

The orphan nuclear receptor RORα regulates circadian transcription of the mammalian core-clock Bmal1

2005 • 453 citations

Association of intrinsic circadian period with morningness-eveningness, usual wake time, and circadian phase.

2001 • 436 citations

The circadian basis of winter depression

2006 • 434 citations

Altered Patterns of Sleep and Behavioral Adaptability in NPAS2-Deficient Mice

2003 • 413 citations

Modeling of a Human Circadian Mutation Yields Insights into Clock Regulation by PER2

2007 • 386 citations

Feedback repression is required for mammalian circadian clock function

2006 • 363 citations

DNA looping between sites for transcriptional activation: self-association of DNA-bound Sp1.

1991 • 348 citations

Control of cell lineage-specific development and transcription by bHLH-PAS proteins

1998 • 347 citations

Circadian Clock-Related Polymorphisms in Seasonal Affective Disorder and their Relevance to Diurnal Preference

2002 • 342 citations

Reciprocal regulation of haem biosynthesis and the circadian clock in mammals

2004 • 338 citations

From in vivo to in silico biology and back

2006 • 294 citations

All's well that ends dead

1999 • 293 citations

A Circadian Signal of Change of Season in Patients With Seasonal Affective Disorder

2001 • 279 citations

UTRdb and UTRsite: specialized databases of sequences and functional elements of 5' and 3' untranslated regions of eukaryotic mRNAs

2000 • 279 citations

Gene-environment interaction and the genetics of depression.

2004 • 278 citations

Design of genetic networks with specified functions by evolution in silico

2004 • 277 citations

Molecular Clock Genes in Man and Lower Animals Possible Implications for Circadian Abnormalities in Depression

2000 • 268 citations

Characterizing a Mammalian Circannual Pacemaker

2006 • 255 citations

DNA looping and Sp1 multimer links: a mechanism for transcriptional synergism and enhancement.

1991 • 254 citations

The central and basolateral nuclei of the amygdala exhibit opposite diurnal rhythms of expression of the clock protein Period2

2005 • 249 citations

Transcriptional activation of the nuclear receptor RZRα by the pineal gland hormone melatonin and identification of CGP 52608 as a synthetic ligand

1995 • 244 citations

Constant darkness is a circadian metabolic signal in mammals

2006 • 225 citations

Metabolic cycles as an underlying basis of biological oscillations

2006 • 224 citations

Clock genes in calendar cells as the basis of annual timekeeping in mammals--a unifying hypothesis

2003 • 221 citations

Signaling mediated by the dopamine D2 receptor potentiates circadian regulation by CLOCK:BMAL1

2006 • 188 citations

NPAS2 as a transcriptional regulator of non-rapid eye movement sleep: Genotype and sex interactions

2006 • 184 citations

UTRdb and UTRsite: specialized databases of sequences and functional elements of 5' and 3' untranslated regions of eukaryotic mRNAs. Update 2002

2002 • 180 citations

A cell-based system that recapitulates the dynamic light-dependent regulation of the vertebrate clock

2001 • 172 citations

Seasonal affective disorder

1998 • 165 citations

UTRdb and UTRsite: a collection of sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs

2004 • 163 citations

Alcohol Consumption and the Body???s Biological Clock

2005 • 159 citations

Seasonal Mood Disorders

1993 • 153 citations

Prokineticin receptor 2 (Prokr2) is essential for the regulation of circadian behavior by the suprachiasmatic nuclei

2007 • 142 citations

Specific correlations between relative synonymous codon usage and protein secondary structure

1998 • 141 citations

The relationship between synonymous codon usage and protein structure

1998 • 136 citations

SNPper: retrieval and analysis of human SNPs

2002 • 134 citations

A molecular perspective of human circadian rhythm disorders

2003 • 133 citations

Maximizing Transcription Efficiency Causes Codon Usage Bias

1996 • 132 citations

Biologic rhythm disorders, depression, and phototherapy. A new hypothesis.

1987 • 129 citations

Seasonal Pattern Assessment Questionnaire

1987 • 124 citations

Selective deficits in the circadian light response in mice lacking PACAP

2004 • 123 citations

Seasonal affective disorder and season-dependent abnormalities of melatonin suppression by light

1990 • 111 citations

Biologic Rhythm Disorders, Depression, and Phototherapy

1987 • 103 citations

Circadian Rest-Activity Disturbances in Seasonal Affective Disorder

1997 • 99 citations

Seasonal depression

2001 • 92 citations

Molecular Mechanism of Cell-autonomous Circadian Gene Expression ofPeriod2, a Crucial Regulator of the Mammalian Circadian Clock

2005 • 65 citations

Role of Cyclic mPer2 Expression in the Mammalian Cellular Clock

2005 • 59 citations

Genome-wide prediction and analysis of function-specific transcription factor binding sites.

2004 • 52 citations

Seasonal Affective Disorder and Serotonin-Related Polymorphisms

2001 • 48 citations

Seasonal and mood independence of low basal prolactin secretion in premenopausal women with seasonal affective disorder

1989 • 44 citations

The serotonin transporter promoter repeat length polymorphism, seasonal affective disorder and seasonality

2003 • 38 citations

Effects of bright light on resting metabolic rate in patients with seasonal affective disorder and control subjects

1990 • 28 citations

Essential Contribution of Intron Sequences to Ca<sup>2+</sup>-Dependent Activation of <i>c-fos</i> Transcription in Pituitary Cells

2000 • 25 citations

Is Seasonal Affective Disorder a Disorder of Circadian Rhythms?

2001 • 11 citations

Involvement of Intronic Sequences in Cell‐Specific Expression of the Peripherin Gene

1999 • 7 citations

The Molecular Basis for Winter Depression

1994 • 7 citations