Low dose linomide in Type I juvenile diabetes of recent onset: a randomised placebo-controlled double blind trial

Classification and Diagnosis of Diabetes Mellitus and Other Categories of Glucose Intolerance

1979 • 4,730 citations

Effects of Cyclosporine Immunosuppression in Insulin-Dependent Diabetes Mellitus of Recent Onset

1984 • 555 citations

Risk Factors for Cyclosporine-Induced Nephropathy in Patients with Autoimmune Diseases

1992 • 409 citations

Immunoregulatory and Cytokine Imbalances in the Pathogenesis of IDDM: Therapeutic Intervention by Immunostimulation?

1994 • 363 citations

Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): similarities between TNF-alpha and interleukin 1.

1990 • 356 citations

Factors Associated with Early Remission of Type I Diabetes in Children Treated with Cyclosporine

1988 • 330 citations

β cell apoptosis in T cell-mediated autoimmune diabetes

1997 • 330 citations

Immunosuppression with Azathioprine and Prednisone in Recent-Onset Insulin-Dependent Diabetes Mellitus

1988 • 304 citations

Age-dependent HLA genetic heterogeneity of type 1 insulin-dependent diabetes mellitus.

1992 • 290 citations

A Comparison of Childhood and Adult Type I Diabetes Mellitus

1989 • 278 citations

Detection of GAD65 Antibodies in Diabetes and Other Autoimmune Diseases Using a Simple Radioligand Assay

1994 • 261 citations

Characterization of the MODY3 phenotype. Early-onset diabetes caused by an insulin secretion defect.

1997 • 206 citations

METABOLIC AND IMMUNOLOGICAL EFFECTS OF CYCLOSPORIN IN RECENTLY DIAGNOSED TYPE 1 DIABETES MELLITUS

1985 • 177 citations

Limited Duration of Remission of Insulin Dependency in Children With Recent Overt Type I Diabetes Treated With Low-Dose Cyclosporin

1990 • 168 citations

Cyclosporin-Induced Remission of IDDM After Early Intervention: Association of 1 yr of Cyclosporin Treatment With Enhanced Insulin Secretion

1988 • 155 citations

Increase in Remission Rate in Newly Diagnosed Type I Diabetic Subjects Treated with Azathioprine

1985 • 138 citations

Treatment of chronic-relapsing experimental autoimmune encephalomyelitis with the synthetic immunomodulator linomide (quinoline-3-carboxamide).

1993 • 112 citations

Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM. Therapeutic intervention by immunostimulation?

1994 • 112 citations

Treatment of secondary progressive multiple sclerosis with the immunomodulator linomide

1996 • 112 citations

Linomide reduces the rate of active lesions in relapsing-remitting multiple sclerosis

1996 • 102 citations

Thymic T cell anergy in autoimmune nonobese diabetic mice is mediated by deficient T cell receptor regulation of the pathway of p21ras activation.

1993 • 97 citations

Augmentation of mouse natural killer cell activity by LS 2616, a new immunomodulator.

1985 • 93 citations

Inhibition of acute, experimental autoimmune encephalomyelitis by the synthetic immunomodulator linomide

1993 • 88 citations

Detection of GAD65 antibodies in diabetes and other autoimmune diseases using a simple radioligand assay

1994 • 83 citations

Management of acute graft-versus-host disease.

1990 • 78 citations

Mechanism of action of the new immunomodulator LS2616 on T cell responses

1987 • 72 citations

Prevention of diabetes mellitus in non-obese diabetic mice by Linomide, a novel immunomodulating drug

1994 • 65 citations

Linomide, a novel immunomodulator that prevents death in four models of septic shock

1993 • 65 citations

STIMULATION OF NK CELL, T CELL, AND MONOCYTE FUNCTIONS BY THE NOVEL IMMUNOMODULATOR LINOMIDE AFTER AUTOLOGOUS BONE MARROW TRANSPLANTATION

1992 • 64 citations

Paradoxical effects of LS-2616 (Linomide) treatment in the type II collagen arthritis model in mice

1989 • 57 citations

Effects of LS-2616 administration upon the autoimmune disease of (NZB x NZW) F1 hybrid mice.

1986 • 57 citations

Long-Term Results of Early Cyclosporin Therapy in Juvenile IDDM

1996 • 51 citations

Effects of the immunomodulator LS 2616 on lymphocyte subpopulations in murine Coxsackievirus B3 myocarditis.

1989 • 49 citations

Evaluation of Islet Cell Antigen (ICA) 512/IA-2 Autoantibody Radioassays Using Overlapping ICA512/IA-2 Constructs¹

1997 • 49 citations

Increase in remission rate in newly diagnosed type I diabetic subjects treated with azathioprine

1985 • 45 citations

Insulin and islet cell autoantibodies as time-dependent covariates in the development of insulin-dependent diabetes: a prospective study in relatives.

1993 • 44 citations

Linomide inhibits programmed cell death of peripheral T cells in vivo

1994 • 44 citations

Immunomodulation of experimental autoimmune myasthenia gravis with linomide

1994 • 42 citations

The Design of Trials for Prevention of IDDM

1993 • 33 citations

Improvement of Diabetic Control and Acceptability of a Three-Injection Insulin Regimen in Diabetic Adolescents: A multicenter controlled study

1993 • 31 citations

Linomide prevents the lethal effect of anti-Fas antibody and reduces Fas-mediated ceramide production in mouse hepatocytes.

1996 • 30 citations

Linomide, a new immunomodulatory drug, shows different effects on homologous versus heterologous collagen-induced arthritis in rats.

1989 • 29 citations

Linomide administration to mice attenuates the induction of nitric oxide synthase elicited by lipopolysaccharide-activated macrophages and prevents nephritis in MRL/Mp-lpr/lpr mice.

1997 • 28 citations

The design of trials for prevention of IDDM

1993 • 17 citations

Prevention of autoimmune diabetes by linomide in nonobese diabetic (NOD) mice is associated with up-regulation of the TCR-mediated activation of p21(ras).

1996 • 17 citations

Cyclosporin A Suppresses Insulin Autoantibodies and Heterologous Insulin Antibodies in Type I Diabetic Children

1988 • 12 citations

Immunotherapy at clinical diagnosis of insulin-dependent diabetes An approach still worth considering

1993 • 8 citations

Cyclosporin A suppresses insulin autoantibodies and heterologous insulin antibodies in type I diabetic children

1988 • 7 citations