DNA Structure Determines Protein Binding and Transcriptional Efficiency of the Proenkephalin cAMP-responsive Enhancer

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Genomic sequencing.

1984 • 8,343 citations

Current protocols in molecular biology

1988 • 7,584 citations

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

DNAase footprinting a simple method for the detection of protein-DNA binding specificity

1978 • 2,092 citations

Transcriptional activation: A complex puzzle with few easy pieces

1994 • 1,112 citations

In Vivo Footprinting of a Muscle Specific Enhancer by Ligation Mediated PCR

1989 • 972 citations

A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence

1989 • 914 citations

Regulation of CREB Phosphorylation in the Suprachiasmatic Nucleus by Light and a Circadian Clock

1993 • 817 citations

A cyclic AMP- and phorbol ester-inducible DNA element

1986 • 780 citations

Transcription factor ATF interacts with the TATA factor to facilitate establishment of a preinitiation complex

1988 • 488 citations

Genomic Sequencing and Methylation Analysis by Ligation Mediated PCR

1989 • 408 citations

Rapid and quantitative preparation of cytoplasmic RNA from small numbers of cells

1988 • 406 citations

Amphetamine regulates gene expression in rat striatum via transcription factor CREB

1994 • 356 citations

Proteins bound at adjacent DNA elements act synergistically to regulate human proenkephalin cAMP inducible transcription.

1988 • 342 citations

Short-Range DNA Looping by the Xenopus HMG-Box Transcription Factor, xUBF

1994 • 216 citations

Isolation and characterization of the rat proenkephalin gene.

1984 • 194 citations

The cAMP-regulated transcription factor CREB interactswith a component of the TFIID complex.

1994 • 192 citations

cAMP-dependent regulation of proenkephalin by JunD and JunB: positive and negative effects of AP-1 proteins.

1991 • 151 citations

The cAMP-response-element-binding protein interacts, but Fos protein does not interact, with the proenkephalin enhancer in rat striatum.

1993 • 145 citations

The effect of depolarization on expression of the human proenkephalin gene is synergistic with cAMP and dependent upon a cAMP-inducible enhancer

1990 • 123 citations

Electrolyte gradient gels for DNA sequencing.

1988 • 97 citations

A single promoter directs both housekeeping and erythroid preferential expression of the human ferrochelatase gene.

1994 • 78 citations

Primary Structure of the Human Proenkephalin Gene

1983 • 73 citations

Mechanism of DNA strand breakage by piperidine at sites of N7-alkylguanines

1986 • 72 citations

CircumVent thermal cycle sequencing and alternative manual and automated DNA sequencing protocols using the highly thermostable VentR (exo-) DNA polymerase.

1992 • 64 citations

Proenkephalin Gene Expression in C6 Rat Glioma Cells: Potentiation of Cyclic Adenosine 3′,5′- Monophosphate-Dependent Transcription by Glucocorticoids

1991 • 61 citations

In Vivo Footprinting and Genomic Sequencing by Ligation-Mediated PCR

1993 • 61 citations

Endogenous opiates: 1993

1994 • 49 citations

Hairpin formation within the enhancer region of the human enkephalin gene.

1991 • 46 citations

Induction of the Rat Prodynorphin Gene through Gs-Coupled Receptors May Involve Phosphorylation-Dependent Derepression and Activation

1994 • 45 citations

Fibroblast growth factor and cyclic AMP (cAMP) synergistically activate gene expression at a cAMP response element.

1994 • 44 citations

Secondary structure creates mismatched base pairs required for high-affinity binding of cAMP response element-binding protein to the human enkephalin enhancer.

1993 • 42 citations

Electron Microscopy Reveals that Transcription Factor TFIIIA Bends 5S DNA

1989 • 37 citations

Electron spectroscopic imaging of chromatic and other nucleoprotein complexes

1992 • 31 citations

Genetic and biochemical analyses of yeast TATA-binding protein mutants.

1993 • 24 citations

Cloning and Characterization of Hamster Proenkephalin Gene

1994 • 22 citations

Hairpin formation within the human enkephalin enhancer region. 1. Kinetic analysis

1994 • 20 citations

Structure and Expression of the Guinea Pig Preproenkephalin Gene: Site-Specific Cleavage in the 3′ Untranslated Region Yields Truncated mRNA Transcripts in Specific Brain Regions

1995 • 18 citations

Hairpin Formation within the Human Enkephalin Enhancer Region. 2. Structural Studies

1994 • 14 citations

[16] Enzyme probes in Vitro

1992 • 10 citations