A single promoter directs both housekeeping and erythroid preferential expression of the human ferrochelatase gene.

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1980 • 15,302 citations

CpG Islands in vertebrate genomes

1987 • 3,315 citations

Firefly luciferase gene: structure and expression in mammalian cells.

1987 • 3,088 citations

The “initiator” as a transcription control element

1989 • 1,597 citations

Dideoxy sequencing method using denatured plasmid templates

1986 • 1,537 citations

Hybridization of nucleic acids immobilized on solid supports

1984 • 1,357 citations

Promoter-specific activation of RNA polymerase II transcription by Sp1

1986 • 1,054 citations

Mechanism of transcriptional activation by Sp1: Evidence for coactivators

1990 • 1,029 citations

Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells

1989 • 931 citations

CpG islands as gene markers in the human genome

1992 • 908 citations

GATA-binding transcription factors in hematopoietic cells

1992 • 845 citations

GATA-binding transcription factors in hematopoietic cells

1992 • 727 citations

A Novel, Erythroid Cell-Specific Murine Transcription Factor that Binds to the CACCC Element and is Related to the Krüppel Family of Nuclear Proteins†

1993 • 703 citations

Erythroid transcription factor NF-E2 is a haematopoietic-specific basic–leucine zipper protein

1993 • 655 citations

DNA-Binding Specificity of GATA Family Transcription Factors

1993 • 629 citations

Transcription from a TATA-less promoter requires a multisubunit TFIID complex.

1991 • 618 citations

Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes

1992 • 577 citations

DNA-Binding Specificities of the GATA Transcription Factor Family

1993 • 553 citations

Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression.

1992 • 533 citations

Alternative chromatin structure at CpG islands

1990 • 480 citations

Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins

1994 • 434 citations

Transcriptional activation and DNA binding by the erythroid factor GF-1/NF-E1/Eryf 1.

1990 • 422 citations

Promoters for housekeeping genes

1986 • 412 citations

Human erythroid 5-aminolevulinate synthase: promoter analysis and identification of an iron-responsive element in the mRNA.

1991 • 374 citations

Two regulatory proteins that bind to the basic transcription element (BTE), a GC box sequence in the promoter region of the rat P-4501A1 gene.

1992 • 354 citations

A sequence-specific, single-strand binding protein activates the far upstream element of c-myc and defines a new DNA-binding motif.

1994 • 315 citations

Alternative transcription and splicing of the human porphobilinogen deaminase gene result either in tissue-specific or in housekeeping expression.

1988 • 313 citations

Cis- and trans-acting elements involved in the regulation of the erythroid promoter of the human porphobilinogen deaminase gene.

1989 • 272 citations

Heme synthetase deficiency in human protoporphyria. Demonstration of the defect in liver and cultured skin fibroblasts.

1975 • 244 citations

Type 1 plasminogen activator inhibitor gene: functional analysis and glucocorticoid regulation of its promoter.

1988 • 222 citations

Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner.

1993 • 169 citations

Expression of delta-aminolevulinate synthase in avian cells: separate genes encode erythroid-specific and nonspecific isozymes.

1989 • 163 citations

Diminished erythroid ferrochelatase activity in protoporphyria.

1975 • 161 citations

Structure of the human ferrochelatase gene

1992 • 159 citations

A T Cell-Specific Transcriptional Enhancer within the Human T Cell Receptor δ Locus

1990 • 140 citations

Molecular cloning and sequence analysis of cDNA encoding human ferrochelatase

1990 • 138 citations

Erythropoietic protoporphyria in the house mouse. A recessive inherited ferrochelatase deficiency with anemia, photosensitivity, and liver disease.

1991 • 132 citations

Hepatic disease in erythropoietic protoporphyria

1975 • 127 citations

Cooperation of GATA-1 and Sp1 can result in synergistic transcriptional activation or interference.

1993 • 116 citations

Human Erythropoietic Protoporphyria: Two point mutations in the ferrochelatase gene

1991 • 116 citations

The erythroid-specific protein cGATA-1 mediates distal enhancer activity through a specialized beta-globin TATA box.

1992 • 98 citations

A molecular defect in human protoporphyria.

1992 • 88 citations

A promoter of the rat insulin-like growth factor II gene consists of minimal control elements

1988 • 88 citations

Nucleotide sequence of mouse 5-aminolevulinic acid synthase cDNA and expression of its gene in hepatic and erythroid tissues

1986 • 85 citations

trans-Activation of a Globin Promoter in Nonerythroid Cells

1991 • 84 citations

The molecular defect of ferrochelatase in a patient with erythropoietic protoporphyria.

1992 • 83 citations

Human T cell activation through the activation-inducer molecule/CD69 enhances the activity of transcription factor AP-1.

1992 • 80 citations

Erythroid-specific activation and derepression of the chick β-globin promoter in vitro

1989 • 76 citations

Characterization of the p150,95 leukocyte integrin alpha subunit (CD11c) gene promoter. Identification of cis-acting elements.

1993 • 66 citations

Molecular and functional characterization of the promoter of ETS2, the human c-ets-2 gene.

1990 • 66 citations

Synergy between the NF-E1 erythroid-specific transcription factor and the CACCC factor in the erythroid-specific promoter of the human porphobilinogen deaminase gene.

1990 • 65 citations

Molecular defect in human erythropoietic protoporphyria with fatal liver failure

1993 • 51 citations

Characterization of Deficient Heme Synthase Activity in Protoporphyria with Cultured Skin Fibroblasts

1980 • 39 citations

Cloning of murine ferrochelatase.

1991 • 38 citations

Molecular Characterization of a Ferrochelatase Gene Defect Causing Anomalous RNA Splicing in Erythropoietic Protoporphyria

1994 • 37 citations

Human erythropoietic protoporphyria: identification of a mutation at the splice donor site of intron 7 causing exon 7 skipping of the ferrochelatase gene

1993 • 35 citations

A novel mutation in erythropoietic protoporphyria: an aberrant ferrochelatase mRNA caused by exon skipping during RNA splicing

1993 • 35 citations

Overabundance of rare-cutting restriction endonuclease sites in the human genome

1987 • 33 citations

Screening for ferrochelatase mutations: molecular heterogeneity of erythropoietic protoporphyria

1994 • 33 citations

Identification of a single base pair deletion (40 del G) in exon 1 of the ferrochelatase gene in patients with erythropoietic protoporphyria

1993 • 31 citations

Characterization of hypersensitive sites, protein-binding motifs, and regulatory elements in both promoters of the mouse porphobilinogen deaminase gene

1991 • 29 citations

Deletion of the ferrochelatase gene in a patient with protoporphyria

1994 • 26 citations

Regulated expression of the overlapping ubiquitous and erythroid transcription units of the human porphobilinogen deaminase (PBG-D) gene introduced into non-erythroid and erythroid cells

1989 • 18 citations

A method for in vitro DNase I footprinting analysis on supercoiled templates.

1994 • 8 citations