The human γ/δ+ and α/β+ T cells: A branched pathway of differentiation

Somatic generation of antibody diversity

1983 • 3,275 citations

Two tandemly organized human genes encoding the T-cell γ constant-region sequences show multiple rearrangement in different T-cell types

1985 • 382 citations

Diversity and rearrangement of the human T cell rearranging γ genes: Nine germ-line variable genes belonging to two subgroups

1986 • 329 citations

The Genetics of Antibody Diversity

1982 • 214 citations

Human γ-chain genes are rearranged in leukaemic T cells and map to the short arm of chromosome 7

1985 • 205 citations

αβ lineage-specific expression of the α T cell receptor gene by nearby silencers

1989 • 182 citations

Rearrangement of two distinct T-cell γ-chain variable-region genes in human DNA

1986 • 174 citations

Subpopulations of human peripheral T gamma delta lymphocytes

1989 • 170 citations

New subgroups in the human T cell rearranging V gamma gene locus.

1987 • 170 citations

Direct evidence for chromosomal inversion during T-cell receptor β-gene rearrangements

1986 • 151 citations

A distinct wave of human T cell receptor gamma/delta lymphocytes in the early fetal thymus: evidence for controlled gene rearrangement and cytokine production.

1990 • 148 citations

T cell receptor β gene sequences in the circular DNA of thymocyte nuclei: Direct evidence for intramolecular DNA deletion in V-D-J joining

1987 • 144 citations

Diversity and structure of human T cell receptor delta chain genes in peripheral blood gamma/delta-bearing T lymphocytes.

1989 • 137 citations

Genetic polymorphism and exon changes of the constant regions of the human T-cell rearranging gene gamma.

1986 • 136 citations

Human T-cell-receptor delta chain: genomic organization, diversity, and expression in populations of cells.

1988 • 136 citations

A unique V-J-C-rearranged gene encodes a gamma protein expressed on the majority of CD3+ T cell receptor-alpha/beta- circulating lymphocytes.

1988 • 133 citations

Isolation of an excision product of T-cell receptor α-chain gene rearrangments

1987 • 124 citations

Rearrangements to the JP1, JP and JP2 segments in the human T‐cell rearranging gamma gene (TRGγ) locus

1987 • 119 citations

Variable region genes in the human T-cell rearranging gamma (TRG) locus: V-J junction and homology with the mouse genes.

1988 • 117 citations

Human T cell gamma chain joining regions and T cell development.

1987 • 114 citations

The chromosomal location of T-cell receptor genes and a T cell rearranging gene: possible correlation with specific translocations in human T cell leukaemia.

1985 • 107 citations

Diversity and organization of human T cell receptor delta variable gene segments.

1989 • 107 citations

Regulated expression and structure of T cell receptor gamma/delta transcripts in human thymic ontogeny.

1991 • 82 citations

T-cell gamma gene is allelically but not isotypically excluded and is not required in known functional T-cell subsets.

1987 • 75 citations

Molecular mapping of the human T cell receptor gamma (TRG) genes and linkage of the variable and constant regions

1989 • 74 citations

The human T-cell receptor γ (TRG) genes

1989 • 68 citations

Further evidence for a sequentially ordered activation of T cell rearranging gamma genes during T lymphocyte differentiation

1988 • 52 citations

Inversion of chromosome 7 in ataxia telangiectasia is generated by a rearrangement between T-cell receptor beta and T-cell receptor gamma genes

1989 • 51 citations

Exon duplication and triplication in the human T-cell receptor gamma constant region genes and RFLP in French, Lebanese, Tunisian, and Black African populations

1989 • 46 citations

Variable region (V delta) gene segment most frequently utilized in adult thymocytes is 3' of the constant (C delta) region.

1988 • 44 citations

Structure of extrachromosomal circular DNAs excised from T-cell antigen receptor alpha and delta-chain loci

1988 • 42 citations

The V gamma locus of the human T cell receptor gamma gene. Repertoire polymorphism of the first variable gene segment subgroup.

1988 • 39 citations

Developmental T cell receptor gene rearrangements: Relatedness of the α/β and γ/δ T cell precursor

1991 • 38 citations

Unusual forms of T cell γ mRNA in a human T cell leukemia cell line: Implications for γ gene expression

1987 • 36 citations

Coordinated V_γ and V_δ gene segment rearrangements in human T cell receptor γ/δ⁺ lymphocytes

1989 • 34 citations

Genetic organization of the human T-cell receptor γ and δ loci

1990 • 32 citations

Characterization of T-cell-receptor gamma (TRG) gene rearrangements in alloreactive T-cell clones

1989 • 30 citations

Organization and orientation of a human T cell receptor δ chain V gene segment that suggests an inversion mechanism is utilized in its rearrangement

1989 • 24 citations

Deletion, insertion, and restriction site polymorphism of the T-cell receptor gamma variable locus in French, Lebanese, Tunisian, and Black African populations

1989 • 21 citations

The human T-cell rearranging gamma (TRG) genes and the gamma T-cell receptors

1988 • 18 citations

Polymorphism of the T-cell receptor gamma variable and constant region genes in a Chinese population

1991 • 17 citations

Reciprocal hybrid joints demonstrate successive V - J rearrangements on the same chromosome in the human TCR gamma locus

1991 • 17 citations

Localization of the human T-cell receptor gamma locus (TCRG) to 7p14→p15 by in situ hybridization

1991 • 14 citations