A Major Role for Prostacyclin in Nitric Oxide–Induced Ocular Vasorelaxation in the Piglet

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

Physiological roles and properties of potassium channels in arterial smooth muscle

1995 • 2,146 citations

International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes.

1994 • 1,729 citations

Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle

1994 • 1,704 citations

Nitric oxide activates cyclooxygenase enzymes.

1993 • 1,416 citations

Biosynthesis and Metabolism of Endothelium-Derived Nitric Oxide

1990 • 1,284 citations

Nitric Oxide: A Physiologic Messenger

1994 • 915 citations

Nitric oxide and cGMP cause vasorelaxation by activation of a charybdotoxin-sensitive K channel by cGMP-dependent protein kinase.

1994 • 819 citations

Endothelium-Dependent Hyperpolarization

1995 • 523 citations

Inward rectifier K+ currents in smooth muscle cells from rat resistance-sized cerebral arteries

1993 • 256 citations

IL-1.beta. induces the coexpression of both nitric oxide synthase and cyclooxygenase by Islets of Langerhans: activation of cyclooxygenase by nitric oxide

1993 • 253 citations

Gender Differences in Coronary Artery Diameter Involve Estrogen, Nitric Oxide, and Ca ²⁺ -Dependent K ⁺ Channels

1996 • 252 citations

Nitric Oxide Produced by Endothelial Cells Increases Production of Eicosanoids Through Activation of Prostaglandin H Synthase

1995 • 239 citations

Dominant expression of mRNA for prostaglandin D synthase in leptomeninges, choroid plexus, and oligodendrocytes of the adult rat brain.

1993 • 239 citations

Nitric oxide-mediated cyclooxygenase activation. A key event in the antiplatelet effects of nitrovasodilators.

1996 • 169 citations

Nitric oxide activates multiple potassium channels in canine colonic smooth muscle.

1995 • 166 citations

Acceleration of Intracellular Calcium Waves in Xenopus Oocytes by Calcium Influx

1993 • 166 citations

Nitric oxide amplifies interleukin 1-induced cyclooxygenase-2 expression in rat mesangial cells.

1996 • 158 citations

NO hyperpolarizes pulmonary artery smooth muscle cells and decreases the intracellular Ca2+ concentration by activating voltage-gated K+ channels.

1996 • 153 citations

Prostacyclin-induced vasodilation in rabbit heart is mediated by ATP-sensitive potassium channels

1993 • 142 citations

Prostaglandin G/H Synthase-2 Is a Major Contributor of Brain Prostaglandins in the Newborn

1995 • 139 citations

Nitric oxide/nucleophile complexes inhibit the in vitro proliferation of A375 melanoma cells via nitric oxide release.

1993 • 137 citations

Calcium‐activated potassium channels in the endothelium of intact rat aorta.

1996 • 135 citations

Interaction Between Nitric Oxide and Prostaglandin H Synthase

1994 • 132 citations

Interaction between nitric oxide and cyclooxygenase pathways

1996 • 128 citations

Heterogeneity of endothelium-dependent regulation in ophthalmic and ciliary arteries.

1993 • 124 citations

Nitric oxide: A physiologic messenger

1995 • 113 citations

Nitric oxide controls arteriolar tone in the retina of the miniature pig.

1995 • 113 citations

Endothelium-dependent regulation of vascular tone of the porcine ophthalmic artery.

1991 • 110 citations

Relaxation of pig coronary arteries by new and potent cGMP analogs that selectively activate type I alpha, compared with type I beta, cGMP-dependent protein kinase.

1992 • 96 citations

KCa channel antagonists reduce NO donor-mediated relaxation of vascular and tracheal smooth muscle

1995 • 82 citations

Role of nitric oxide and Ca++-dependent K+ channels in mediating heterogeneous microvascular responses to acetylcholine in different vascular beds.

1997 • 79 citations

Shear Stress-Induced Release of PGE2and PGI2by Vascular Smooth Muscle Cells

1996 • 72 citations

Increased Nitric Oxide Synthesis and Action Preclude Choroidal Vasoconstriction to Hyperoxia in Newborn Pigs

1996 • 69 citations

Nitric Oxide in Retinal and Choroidal Blood Flow Autoregulation in Newborn Pigs: Interactions with Prostaglandins

1996 • 68 citations

Nitric Oxide: A Prostaglandin H Synthase 1 and 2 Reducing Cosubstrate That Does Not Stimulate Cyclooxygenase Activity or Prostaglandin H Synthase Expression in Murine Macrophages

1996 • 66 citations

Ibuprofen enhances retinal and choroidal blood flow autoregulation in newborn piglets.

1991 • 64 citations

Evidence that prostaglandins I2, E2, and D2 may activate ATP sensitive potassium channels in the isolated rat heart

1994 • 53 citations

Immunoquantitation of thromboxane synthase in human tissues.

1990 • 51 citations

Role of activation of calcium-sensitive K+ channels in NO- and hypoxia-induced pial artery vasodilation

1997 • 50 citations

Nitric oxide modulation of agonist-evoked intracellular Ca2+ release in neurosecretory PC-12 cells: inhibition of phospholipase C activity via cyclic GMP-dependent protein kinase I.

1995 • 49 citations

H2O2 effects on cerebral prostanoids and pial arteriolar diameter in piglets

1990 • 45 citations

Ontogenic increase in PGE₂ and PGF_2α receptor density in brain microvessels of pigs

1994 • 42 citations

A comparison of the effects of SCA40, NS 004 and NS 1619 on large conductance Ca²⁺‐activated K⁺ channels in bovine tracheal smooth muscle cells in culture

1995 • 38 citations

Relaxation by bradykinin in porcine ciliary artery. Role of nitric oxide and K(+)-channels.

1997 • 36 citations

Mediation by prostaglandins of the nitric oxide‐induced neurogenic vasodilatation in rat skin

1995 • 35 citations

Reduced responses of retinal vessels of the newborn pig to prostaglandins but not to thromboxane

1994 • 35 citations

Modification by LY 83583 and methylene blue of relaxation induced by nitric oxide, glyceryl trinitrate, sodium nitroprusside and atriopeptin in aortae of the rat, guinea-pig and rabbit

1994 • 29 citations

Characterization and ontogeny of PGE2 and PGF2α receptors on the retinal vasculature of the pig

1995 • 28 citations

Prostaglandin biosynthesis in the microcirculation: Regulation by endothelial and non-endothelial factors

1993 • 26 citations

Mechanisms of the biphasic effects of peroxides on the retinal vasculature of newborn and adult pigs

1995 • 25 citations

Regulation of prostanoid vasomotor effects and receptors in choroidal vessels of newborn pigs

1997 • 25 citations

Comparison of the effects of nicorandil, pinacidil and nitroglycerin on hypoxic and hypercapnic pulmonary vasoconstriction in the isolated perfused lung of rat

1996 • 16 citations

A concept for the mechanism of prostacyclin and thromboxane A2 biosynthesis.

1990 • 12 citations

Activation of Endothelial Guanylate Cyclase Inhibits Cellular Reactivity

1995 • 8 citations

Effect of Short-Term Administration of Cromakalim on Renal Hemodynamics and Eicosanoid Excretion in Essential Hypertension

1991 • 4 citations