Differential responses of CD4+CD45RA+ and CD4+CD29+ subsets to activated CD8+ cells: Enhanced stimulation of the CD4+CD45RA+ subset by cells from patients with multiple sclerosis

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

New diagnostic criteria for multiple sclerosis: Guidelines for research protocols

1983 • 7,404 citations

Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells.

1988 • 930 citations

Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-gamma production.

1988 • 917 citations

The isolation and characterization of the human suppressor inducer T cell subset.

1985 • 860 citations

Human naive and memory T cells

1988 • 793 citations

The isolation and characterization of the human helper inducer T cell subset.

1985 • 708 citations

A functional dichotomy in CD4+ T lymphocytes

1988 • 369 citations

Differential activation requirements for virgin and memory T cells.

1988 • 271 citations

Selective Loss of the Suppressor-Inducer T-Cell Subset in Progressive Multiple Sclerosis

1987 • 240 citations

MS: a CNS and systematic autoimmune disease

1989 • 231 citations

Loss of CD45R (Lp220) represents a post-thymic T cell differentiation event.

1988 • 218 citations

The functionally distinct subpopulations of human CD4+ helper/inducer T lymphocytes defined by anti-CD45R antibodies derive sequentially from a differentiation pathway that is regulated by activation-dependent post-thymic differentiation.

1988 • 213 citations

Suppressor effects and cyclic AMP accumulation by the CD29 molecule of CD4+ lymphocytes

1989 • 109 citations

Activated suppressor cell dysfunction in progressive multiple sclerosis.

1986 • 103 citations

T Cells in Multiple Sclerosis and Inflammatory Central Nervous System Diseases

1987 • 99 citations

Abnormalities in CD4+ T-lymphocyte subsets in inflammatory rheumatic diseases

1988 • 85 citations

The 2H4 (CD45R) antigen is selectively decreased in multiple sclerosis lesions.

1988 • 82 citations

Effects of interferon-γ on the activation of human T lymphocytes

1988 • 82 citations

Loss of functional suppression is linked to decreases in circulating suppressor inducer (CD4 + 2H4 +) T Cells in multiple sclerosis

1988 • 78 citations

Immunoregulatory T lymphocytes in man. Soluble antigen-specific suppressor-inducer T lymphocytes are derived from the CD4+CD45R-p80+ subpopulation.

1987 • 66 citations

Lymphokine regulation of CD45R expression on human T cell clones.

1989 • 61 citations

Defective suppressor cell function mediated by T8+ cell lines from patients with progressive multiple sclerosis.

1986 • 59 citations

Altered regulation of mitogen responsiveness by suppressor cells in multiple sclerosis.

1979 • 59 citations

Multiple sclerosis

1988 • 52 citations

Lymphokine gene expression related to CD4 T cell subset (CD45R/CDw29) phenotype conversion

1989 • 49 citations

Leukocyte membrane adhesion proteins LFA-1, CR3 and p150,95: A review of functional and regulatory aspects

1989 • 46 citations

Increased proportion of CD4+ CDw29+ CD45R− UCHL-1+ lymphocytes in the cerebrospinal fluid of both multiple sclerosis patients and healthy individuals

1989 • 42 citations

Interleukin-2 production and response by helper T-cell subsets in man.

1988 • 37 citations

Virgin and memory T cells have different requirements for activation via the CD² molecule

1989 • 33 citations

CD4CD45R cells are preferentially activated through the CD2 pathway

1988 • 33 citations

T-cell subsets in multiple sclerosis: A comparative study between cell surface antigens and function

1984 • 30 citations

Activated suppressor cell function in multiple sclerosis — clinical correlations☆

1988 • 23 citations

Activated suppressor cell function in severely disabled patients with multiple sclerosis

1989 • 19 citations

Immunoregulatory properties of T‐cell lines derived from the systemic and intrathecal compartments: A phenotypic and functional study

1990 • 15 citations

Mitogen‐Induced Interleukin 2 and Gamma Interferon Production by CD4⁺ and CD8⁺ Cells of Patients with Inflammatory Arthritides. A Comparison between Cells from Synovial Fluid and Peripheral Blood

1989 • 13 citations

OKT3 induces suppressor cells for mixed lymphocyte and PHA mitogenic responses in human peripheral lymphocytes

1981 • 10 citations

Suppressor T cell induction by soluble OKT3 antibody does not require cross‐linking of the T3 molecule

1985 • 8 citations

Monoclonal antibody 4B4 blocks suppression of the immune response to Cryptomeria japonica pollen antigen

1988 • 8 citations