Overgrowth of human synovial cells driven by the human T cell leukemia virus type I tax gene.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma

1980 • 5,022 citations

Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase

1988 • 4,259 citations

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

1984 • 3,150 citations

ANTIBODIES TO HUMAN T-LYMPHOTROPIC VIRUS TYPE-I IN PATIENTS WITH TROPICAL SPASTIC PARAPARESIS

1985 • 2,840 citations

Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera.

1981 • 2,281 citations

Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease.

1982 • 2,170 citations

Adult T-cell leukemia: clinical and hematologic features of 16 cases

1977 • 2,119 citations

Adult T-cell leukemia: clinical and hematologic features of 16 cases

1977 • 1,750 citations

Human adult T-cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA.

1983 • 1,555 citations

In Vivo Footprinting of a Muscle Specific Enhancer by Ligation Mediated PCR

1989 • 972 citations

Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease.

1984 • 886 citations

HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-κB-like factor

1988 • 607 citations

The tat Gene of Human T-Lymphotropic Virus Type 1 Induces Mesenchymal Tumors in Transgenic Mice

1987 • 522 citations

Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type 1.

1986 • 519 citations

The pX Protein of HTLV-I Is a Transcriptional Activator of Its Long Terminal Repeats

1985 • 514 citations

The ability of a ternary complex to form over the serum response element correlates with serum inducibility of the human c-fos promoter

1989 • 495 citations

HTLV-I Tax Induces Cellular Proteins that Activate the κB Element in the IL-2 Receptor α Gene

1988 • 480 citations

Oncogenic transformation by the tax gene of human T-cell leukemia virus type I in vitro.

1990 • 439 citations

Evidence for aberrant activation of the interleukin-2 autocrine loop by HTLV-1-encoded p40x and T3/Ti complex triggering

1987 • 438 citations

Regulation of the human interleukin-2 receptor α chain promoter: Activation of a nonfunctional promoter by the transactivator gene of HTLV-I

1987 • 423 citations

Activation of interleukin 2 and interleukin 2 receptor (Tac) promoter expression by the trans-activator (tat) gene product of human T-cell leukemia virus, type I.

1987 • 413 citations

Genomic Sequencing and Methylation Analysis by Ligation Mediated PCR

1989 • 408 citations

c-fos promoter trans-activation by the tax1 protein of human T-cell leukemia virus type I.

1988 • 361 citations

Transformation to continuous growth of primary human T lymphocytes by human T-cell leukemia virus type I X-region genes transduced by a Herpesvirus saimiri vector.

1989 • 359 citations

A Transcriptional Activator Protein Encoded by the x- lor Region of the Human T-Cell Leukemia Virus

1985 • 346 citations

Induction of Inflammatory Arthropathy Resembling Rheumatoid Arthritis in Mice Transgenic for HTLV-I

1991 • 344 citations

Cellular Transcription Factors and Regulation of IL-2 Receptor Gene Expression by HTLV-I tax Gene Product

1988 • 327 citations

Kappa B-Specific DNA Binding Proteins: Role in the Regulation of Human Interleukin-2 Gene Expression

1989 • 327 citations

Role of human T-cell leukemia virus type 1 X region proteins in immortalization of primary human lymphocytes in culture

1992 • 311 citations

Inducible binding of a factor to the c-fos enhancer

1986 • 310 citations

c-fos Sequence Necessary for Basal Expression and Induction by Epidermal Growth Factor, 12-O-Tetradecanoyl Phorbol-13-Acetate and the Calcium Ionophore

1987 • 304 citations

Detection of mRNA for the tax1/rex1 gene of human T-cell leukemia virus type I in fresh peripheral blood mononuclear cells of adult T-cell leukemia patients and viral carriers by using the polymerase chain reaction.

1989 • 289 citations

A Transgenic Mouse Model for Human Neurofibromatosis

1987 • 278 citations

Constitutive production of inflammatory and mitogenic cytokines by rheumatoid synovial fibroblasts.

1991 • 263 citations

Transcriptional (p40x) and post-transcriptional (p27x-III) regulators are required for the expression and replication of human T-cell leukemia virus type I genes.

1987 • 245 citations

Direct evidence that p40x of human T-cell leukemia virus type I is a trans-acting transcriptional activator.

1986 • 229 citations

The human T-lymphotropic virus type I tax gene can cooperate with the ras oncogene to induce neoplastic transformation of cells.

1990 • 222 citations

Augmented interleukin‐1 production and hla–dr expression in the synovium of rheumatoid arthritis patients

1988 • 222 citations

Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: novel mRNAs and proteins produced by HTLV type I

1992 • 217 citations

Enzymatic amplification of HTLV-I viral sequences from peripheral blood mononuclear cells and infected tissues

1988 • 201 citations

A transcriptional enhancer sequence of HTLV-I is responsible for trans-activation mediated by p40 chi HTLV-I.

1986 • 190 citations

Increased replication of HTLV‐I in HTLV‐I–associated myelopathy

1989 • 179 citations

HTLV-I tax induces cellular proteins that activate the kappa B element in the IL-2 receptor alpha gene

1988 • 171 citations

T-Cell Activation Signals and Human T-Cell Leukemia Virus Type I-Encoded p40^x Protein Activate the Mouse Granulocyte-Macrophage Colony-Stimulating Factor Gene Through a Common DNA Element

1988 • 171 citations

Increased HTLV‐I proviral DNA in HTLV‐I–associated myelopathy: A quantitative polymerase chain reaction study

1991 • 153 citations

Nuclear proteins interacting with the promoter region of the human granulocyte/macrophage colony-stimulating factor gene.

1988 • 129 citations

High human T-cell lymphotropic virus type I proviral DNA load with polyclonal integration in peripheral blood mononuclear cells of French West Indian, Guianese, and African patients with tropical spastic paraparesis

1990 • 129 citations

Effect of human T-cell leukemia virus type I tax protein on activation of the human vimentin gene

1990 • 124 citations

Type I human T cell leukemia virus tax protein transforms rat fibroblasts through the cyclic adenosine monophosphate response element binding protein/activating transcription factor pathway.

1991 • 124 citations

Regulation of expression of human granulocyte/macrophage colony-stimulating factor.

1986 • 122 citations

Detection of human T cell lymphotropic virus type I proviral DNA and its gene expression in synovial cells in chronic inflammatory arthropathy.

1991 • 121 citations

Spontaneous production of an interleukin 1-like factor by cloned rheumatoid synovial cells in long-term culture.

1987 • 113 citations

Sequence analysis of the HLA-DRß and HLA-DQß loci from three Pemphigus vulgaris patients

1988 • 113 citations

Arthritis in patients infected with human T lymphotropic virus type I. Clinical and immunopathologic features

1991 • 101 citations

The fos Gene as "Master Switch"

1987 • 94 citations

Two adjacent promoter elements mediate nerve growth factor activation of the c-fos gene and bind distinct nuclear complexes.

1988 • 79 citations

T-cell activation signals and human T-cell leukemia virus type I-encoded p40x protein activate the mouse granulocyte-macrophage colony-stimulating factor gene through a common DNA element.

1988 • 72 citations

Characterization of the human granulocyte-macrophage colony-stimulating factor promoter region by genetic analysis: correlation with DNase I footprinting.

1988 • 69 citations

Adult t cell leukemia presenting with prolifeerative synovitis

1988 • 54 citations

Constitutive production of interleukin 6/B cell stimulatory factor-2 from inflammatory synovium

1989 • 52 citations

Expression of a Provirus of Human T Cell leukaemia Virus Type I by DNA Transfection

1987 • 52 citations

Modulation of c‐fos and c‐myc mRNA levels in normal human lymphocytes by calcium ionophore A23187 and phorbol ester

1986 • 45 citations

trans activation of nerve growth factor in transgenic mice containing the human T-cell lymphotropic virus type I tax gene.

1991 • 33 citations

Leukemia‐associated arthritis: identification of leukemic cells in synovial fluid using monoclonal and polyclonal antibodies

1984 • 33 citations

c-fos transcriptional activation by IL-2 in mouse CTL-L2 cells is mediated through two distinct signal transduction pathways converging on the same enhancer element.

1991 • 22 citations

Characterization of the Human Granulocyte-Macrophage Colony-Stimulating Factor Promoter Region by Genetic Analysis: Correlation with DNase I Footprinting

1988 • 15 citations

Receptor-mediated phagocytosis by macrophages induces a calcium-dependent transient increase in c-fos transcription.

1989 • 14 citations

Enzymatic amplification of HTLV-I viral sequences from peripheral blood mononuclear cells and infected tissues

1988 • 11 citations

High human T-cell lymphotropic virus type I proviral DNA load with polyclonal integration in peripheral blood mononuclear cells of French West Indian, Guianese, and African patients with tropical spastic paraparesis

1990 • 10 citations

Intranuclear topological distribution of HIV‐1 trans‐activators

1992 • 10 citations

In Vivo Footprinting of a Muscle Specific Enhancer by Ligation Mediated PCR

1990 • 5 citations

Regulation ofexpression ofhumangranulocyte/macrophage colony-stimulati ng factor

1986 • 2 citations